-
公开(公告)号：US20210163417A1
公开(公告)日：2021-06-03
申请号：US16921297
申请日：2020-07-06
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Michael Lainchbury , Emanuela Gancia , Eileen Seward , Andrew Madin , David Favor , Kin Chiu Fong , Yonghan Hu , Andrew Good
IPC: C07D217/22 , A61K31/549 , A61P35/00 , A61K45/06 , C07D401/04 , A61K31/4725 , A61K31/506 , A61K31/501 , C07D471/04 , C07D413/04 , C07D413/14 , A61K31/5377 , C07D417/04 , A61K31/4985 , C07D401/14 , C07D487/04 , A61K31/551 , C07D498/04 , A61K31/5383 , C07D405/14 , C07D519/00 , C07D498/14 , C07D513/04 , A61K31/554 , A61K31/55 , A61K31/472 , C07D409/14 , C07D491/04 , C07D487/14
Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
-
公开(公告)号：US20180282328A1
公开(公告)日：2018-10-04
申请号：US15942321
申请日：2018-03-30
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Blake Daniels , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu
IPC: C07D471/04 , A61K45/06 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K31/55
CPC classification number: C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K45/06 , A61P35/00 , C07D519/00
Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
-
公开(公告)号：US20180282282A1
公开(公告)日：2018-10-04
申请号：US15942333
申请日：2018-03-30
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Michael Lainchbury , Emanuela Gancia , Eileen Seward , Andrew Madin , David Favor , Kin Chiu Fong , Yonghan Hu , Andrew Good
IPC: C07D217/22 , A61K31/472 , A61P35/00 , A61K45/06 , C07D401/04 , A61K31/4725 , A61K31/506 , A61K31/501 , C07D471/04 , C07D413/04 , C07D413/14 , A61K31/5377 , C07D417/04 , A61K31/4985 , C07D401/14 , C07D487/04 , A61K31/551 , C07D498/04 , A61K31/5383 , C07D405/14 , C07D519/00 , C07D498/14 , C07D513/04 , A61K31/554 , A61K31/55 , A61K31/549
Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
-
公开(公告)号：US12208088B2
公开(公告)日：2025-01-28
申请号：US17204089
申请日：2021-03-17
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Craig Stivala , BinQing Wei , Bryan K. Chan , Timothy Heffron , Michael Lainchbury , Andrew Madin , Terry Aaron Panchal , Eileen Mary Seward , Toby Blench , Matthew W. Cartwright , Elsa Amandine Dechaux , Richard Elliott , Emanuela Gancia
IPC: A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/5377 , A61K45/06 , A61P35/00 , C07D471/04 , C07D471/10 , C07D471/20 , C07D487/04 , C07D487/20 , C07D491/20 , C07D519/00
Abstract: Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.
-
公开(公告)号：US10975095B2
公开(公告)日：2021-04-13
申请号：US16034207
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Snahel Patel , Gregory Hamilton , Guiling Zhao , Huifen Chen , Blake Daniels , Craig Stivala
IPC: C07D498/04 , C07D487/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00
Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
-
公开(公告)号：US20190127382A1
公开(公告)日：2019-05-02
申请号：US16175206
申请日：2018-10-30
Applicant: Genentech, Inc.
Inventor： Snahel Patel , Gregory Hamilton , Craig Stivala , Huifen Chen , Blake Daniels
IPC: C07D487/04
Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
-
公开(公告)号：US20170008877A1
公开(公告)日：2017-01-12
申请号：US15200058
申请日：2016-07-01
Applicant: Genentech, Inc.
Inventor： Snahel PATEL , Gregory HAMILTON , Craig Stivala , Huifen Chen , Guiling Zhao
IPC: C07D403/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D498/04 , C07D491/044 , C07D413/14 , C07D491/048 , C07D413/12 , C07D491/052
CPC classification number: C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D491/10 , C07D495/04 , C07D498/04 , C07D519/00
Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
Abstract translation: 其中R1，X，Z1，L，n，A环，B环和C环如本文所述，包括该化合物的药物组合物和使用该化合物的方法。
-
公开(公告)号：US20220370420A1
公开(公告)日：2022-11-24
申请号：US17204089
申请日：2021-03-17
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Craig Stivala , BinQing Wei , Bryan K. Chan , Timothy Heffron , Michael Lainchbury , Andrew Madin , Terry Aaron Panchal , Eileen Mary Seward , Toby Blench , Matthew W. Cartwright , Elsa Amandine Dechaux , Richard Elliott , Emanuela Gancia
IPC: A61K31/437 , A61K45/06 , C07D471/10 , C07D491/20 , C07D519/00 , C07D487/20 , C07D471/20 , A61K31/5377 , A61K31/444 , A61K31/496 , A61K31/513 , A61K31/4985
Abstract: Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.
-
公开(公告)号：US11098058B2
公开(公告)日：2021-08-24
申请号：US16034207
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Snahel Patel , Gregory Hamilton , Guiling Zhao , Huifen Chen , Blake Daniels , Craig Stivala
IPC: C07D498/04 , C07D487/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00
Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
-
公开(公告)号：US11034692B1
公开(公告)日：2021-06-15
申请号：US16542129
申请日：2019-08-15
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Blake Daniels , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu
IPC: C07D471/04 , A61K45/06 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K31/55
Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
