公开(公告)号：US12202824B2

公开(公告)日：2025-01-21

申请号：US17816855

申请日：2022-08-02

Applicant: Genentech, Inc.

Inventor： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC: C07D413/14 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/522 ,  A61K31/53 ,  A61P11/00 ,  A61P19/02 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  C07D473/08 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US11655245B2

公开(公告)日：2023-05-23

申请号：US16903020

申请日：2020-06-16

Applicant: Genentech, Inc.

Inventor： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC: A61K31/427 ,  A61P11/00 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D513/04 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D413/14

CPC classification number: C07D413/14 ,  A61K31/427 ,  A61P11/00 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention relates to methods of using compounds formula I:




and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US10710994B2

公开(公告)日：2020-07-14

申请号：US16355352

申请日：2019-03-15

Applicant: Genentech, Inc.

Inventor： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC: A61P23/00 ,  A61P11/00 ,  A61P29/00 ,  A61P25/00 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D413/14 ,  C07D498/04 ,  C07D513/04 ,  A61K31/427

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20190284179A1

公开(公告)日：2019-09-19

申请号：US16355352

申请日：2019-03-15

Applicant: Genentech, Inc.

Inventor： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC: C07D413/14 ,  C07D473/30 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  C07D487/04 ,  A61P25/00 ,  A61P29/00

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US10913742B2

公开(公告)日：2021-02-09

申请号：US16421114

申请日：2019-05-23

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Daniel Shore ,  Elisia Villemure ,  Matthew Volgraf ,  Baihua Hu ,  Aijun Lu ,  Andrew Cridland ,  Stuart Ward ,  Francis Beaumier ,  Martin Dery ,  Robin Larouche-Gauthier

IPC: C07D487/04 ,  C07D473/30 ,  C07D471/04 ,  C07D513/04 ,  A61K31/519 ,  A61P11/06 ,  C07D498/04

Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.

公开(公告)号：US20200308161A1

公开(公告)日：2020-10-01

申请号：US16903020

申请日：2020-06-16

Applicant: Genentech, Inc.

Inventor： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC: C07D413/14 ,  C07D473/30 ,  C07D471/04 ,  A61P29/00 ,  C07D513/04 ,  C07D487/04 ,  A61P25/00 ,  C07D498/04 ,  A61K31/427 ,  A61P23/00 ,  A61P11/00

Abstract: The invention relates to methods of using compounds formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US10711004B2

公开(公告)日：2020-07-14

申请号：US16558718

申请日：2019-09-03

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Brian Safina ,  Daniel Shore ,  Jack Terrett ,  Elisia Villemure ,  Matthew Volgraf ,  Stuart Ward ,  Aijun Lu ,  Robin Larouche-Gauthier ,  Francis Beaumier ,  Martin Dery ,  Lea Constantineau-Forget ,  Chantal Grand-Maitre ,  Luce Lepissier

IPC: C07D473/30 ,  C07D471/04 ,  C07D487/04 ,  C07D473/08

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.