公开(公告)号：US09994551B2

公开(公告)日：2018-06-12

申请号：US15801178

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Monique Bodil van Niel ,  Andrew Cridland ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward ,  Paul Winship

IPC: C07D403/12 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D403/12 ,  C07D237/26 ,  C07D237/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US11008312B2

公开(公告)日：2021-05-18

申请号：US16398795

申请日：2019-04-30

Applicant: Genentech, Inc.

Inventor： Sarah M. Bronner ,  James J. Crawford ,  Andrew Cridland ,  Patrick Cyr ,  Benjamin Fauber ,  Emanuela Gancia ,  Alberto Gobbi ,  Christopher Hurley ,  Jonathan Killen ,  Wendy Lee ,  Olivier Rene ,  Monique Bodil Van Niel ,  Stuart Ward ,  Paul Winship ,  Jason Zbieg

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D401/14

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US10913742B2

公开(公告)日：2021-02-09

申请号：US16421114

申请日：2019-05-23

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Daniel Shore ,  Elisia Villemure ,  Matthew Volgraf ,  Baihua Hu ,  Aijun Lu ,  Andrew Cridland ,  Stuart Ward ,  Francis Beaumier ,  Martin Dery ,  Robin Larouche-Gauthier

IPC: C07D487/04 ,  C07D473/30 ,  C07D471/04 ,  C07D513/04 ,  A61K31/519 ,  A61P11/06 ,  C07D498/04

Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.

公开(公告)号：US20180222882A1

公开(公告)日：2018-08-09

申请号：US15801201

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Monique Bodil van Niel ,  Andrew Cridland ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC: C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D401/14 ,  C07D491/107 ,  A61P19/02 ,  A61P25/28 ,  A61P17/06 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06

CPC classification number: C07D401/04 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D491/107

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, A, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20190263794A1

公开(公告)日：2019-08-29

申请号：US16398795

申请日：2019-04-30

Applicant: Genentech, Inc.

Inventor： Sarah M. Bronner ,  James J. Crawford ,  Andrew Cridland ,  Patrick Cyr ,  Benjamin Fauber ,  Emanuela Gancia ,  Alberto Gobbi ,  Christopher Hurley ,  Jonathan Killen ,  Wendy Lee ,  Olivier Rene ,  Monique Bodil Van Niel ,  Stuart Ward ,  Paul Winship ,  Jason Zbieg

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US10280144B2

公开(公告)日：2019-05-07

申请号：US15801192

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  James J. Crawford ,  Sarah M. Bronner ,  Monique Bodil van Niel ,  Andrew Cridland ,  Emanuela Gancia ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC: C07D237/26 ,  C07D237/28

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US09981916B2

公开(公告)日：2018-05-29

申请号：US14533358

申请日：2014-11-05

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Andrew Cridland ,  Benjamin Fauber ,  Alberto Gobbi ,  Christopher Hurley ,  David Hurst ,  Jonathan Killen ,  Robert Maxey ,  Stuart Ward

IPC: C07D237/28 ,  C07D403/06 ,  C07D413/06 ,  C07D401/04 ,  C07D417/04 ,  C07D405/12 ,  C07D491/048 ,  C07D403/14 ,  C07D491/107 ,  C07D401/12

CPC classification number: C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D491/048 ,  C07D491/107

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20180072683A1

公开(公告)日：2018-03-15

申请号：US15801192

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  James J. Crawford ,  Sarah M. Bronner ,  Monique Bodil van Niel ,  Andrew Cridland ,  Emanuela Gancia ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC: C07D237/26

CPC classification number: C07D237/26 ,  C07D237/28

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20180051010A1

公开(公告)日：2018-02-22

申请号：US15801178

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Monique Bodil van Niel ,  Andrew Cridland ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward ,  Paul Winship

IPC: C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D401/12 ,  C07D237/26 ,  C07D487/04 ,  C07D471/04 ,  C07D413/14 ,  C07D413/04

CPC classification number: C07D403/12 ,  C07D237/26 ,  C07D237/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20150126491A1

公开(公告)日：2015-05-07

申请号：US14533358

申请日：2014-11-05

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Andrew Cridland ,  Benjamin Fauber ,  Alberto Gobbi ,  Christopher Hurley ,  David Hurst ,  Jonathan Killen ,  Robert Maxey ,  Stuart Ward

IPC: C07D237/28 ,  C07D413/06 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D491/048 ,  C07D403/14 ,  C07D491/107 ,  C07D403/06 ,  C07D417/04

CPC classification number: C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D491/048 ,  C07D491/107

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药用盐，其中X，Ar 1，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。