公开(公告)号：US20140031330A1

公开(公告)日：2014-01-30

申请号：US13939962

申请日：2013-07-11

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Simon Gaines ,  Alberto Gobbi ,  Olivier Rene ,  David Vesey ,  Stuart Ward

IPC: C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D295/185

CPC classification number: C07D295/185 ,  C07D275/02 ,  C07D279/02 ,  C07D281/02 ,  C07D291/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/10 ,  C07D498/10 ,  C07D513/10 ,  C07D515/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US09115101B2

公开(公告)日：2015-08-25

申请号：US13939962

申请日：2013-07-11

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Simon Gaines ,  Alberto Gobbi ,  Olivier Rene ,  David Vesey ,  Stuart Ward

IPC: C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D279/02 ,  C07D281/02 ,  C07D291/02 ,  C07D295/185 ,  C07D491/10 ,  C07D513/10 ,  A61K31/541 ,  A61P19/02 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D275/02 ,  C07D498/10 ,  C07D515/12

CPC classification number: C07D295/185 ,  C07D275/02 ,  C07D279/02 ,  C07D281/02 ,  C07D291/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/10 ,  C07D498/10 ,  C07D513/10 ,  C07D515/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US20150197529A1

公开(公告)日：2015-07-16

申请号：US14593260

申请日：2015-01-09

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi ,  Olivier Rene ,  Monique Bodil van Niel ,  Emanuela Gancia ,  Simon Gaines ,  Tammy Laddywahetty ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D491/113 ,  C07D491/107 ,  C07D417/12 ,  C07D417/14 ,  C07D279/02

CPC classification number: C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107 ,  C07D491/113

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US10131644B2

公开(公告)日：2018-11-20

申请号：US15199447

申请日：2016-06-30

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Emanuela Gancia ,  Simon Gaines ,  Alberto Gobbi ,  Christopher Hurley ,  Tammy Ladduwahetty ,  Olivier Rene ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D279/02 ,  C07D417/10 ,  C07D417/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

公开(公告)号：US20160168141A1

公开(公告)日：2016-06-16

申请号：US15047523

申请日：2016-02-18

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi ,  Olivier Rene ,  Monique Bodil van Niel ,  Emanuela Gancia ,  Simon Gaines ,  Tammy Ladduwahetty ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D417/10

CPC classification number: C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107 ,  C07D491/113

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20140163024A1

公开(公告)日：2014-06-12

申请号：US14101566

申请日：2013-12-10

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Olivier Rene ,  Monique Bodil van Niel ,  Simon Gaines ,  Jonathan Killen ,  Stuart Ward

IPC: C07D295/26 ,  C07D295/096 ,  C07D401/12 ,  C07D295/185 ,  C07D211/58 ,  C07D211/96

CPC classification number: C07D295/26 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/96 ,  C07D295/096 ,  C07D295/116 ,  C07D295/185 ,  C07D401/12

Abstract: Compounds of the formula Ia or Ib: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式Ia或Ib化合物或其药学上可接受的盐，其中m，n，p，q，r，A，X 1，X 2，X 3，X 4，Y，Z，R 1，R 2，R 3，R 4，R 5，R 6 ，R7和R8如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US09751873B2

公开(公告)日：2017-09-05

申请号：US15047523

申请日：2016-02-18

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi ,  Olivier Rene ,  Monique Bodil van Niel ,  Emanuela Gancia ,  Simon Gaines ,  Tammy Ladduwahetty ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D417/14 ,  C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D491/107 ,  C07D491/113 ,  C07D487/08

CPC classification number: C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107 ,  C07D491/113

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20170137393A1

公开(公告)日：2017-05-18

申请号：US15199447

申请日：2016-06-30

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Emanuela Gancia ,  Simon Gaines ,  Alberto Gobbi ,  Christopher Hurley ,  Tammy Ladduwahetty ,  Olivier Rene ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D279/02 ,  C07D417/12 ,  C07D417/10

CPC classification number: C07D279/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

公开(公告)号：US09382222B2

公开(公告)日：2016-07-05

申请号：US14101566

申请日：2013-12-10

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Olivier Rene ,  Monique Bodil van Niel ,  Simon Gaines ,  Jonathan Killen ,  Stuart Ward

IPC: C07D241/04 ,  C07D295/00 ,  A61K31/497 ,  C07D295/26 ,  C07D211/58 ,  C07D211/96 ,  C07D295/096 ,  C07D295/185 ,  C07D401/12 ,  C07D211/46 ,  C07D295/116 ,  C07D211/62

CPC classification number: C07D295/26 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/96 ,  C07D295/096 ,  C07D295/116 ,  C07D295/185 ,  C07D401/12

Abstract: Compounds of the formula Ia or Ib: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式Ia或Ib化合物或其药学上可接受的盐，其中m，n，p，q，r，A，X 1，X 2，X 3，X 4，Y，Z，R 1，R 2，R 3，R 4，R 5，R 6 ，R7和R8如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。