公开(公告)号：US20240306925A1

公开(公告)日：2024-09-19

申请号：US18429343

申请日：2024-01-31

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Dominic Yurk ,  Yaser Abu-Mostafa ,  Alaina Ann Brinley Rajagopal

IPC: A61B5/021 ,  A61B5/00

CPC classification number: A61B5/02133 ,  A61B5/6832 ,  A61B5/7405 ,  A61B5/02141

Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.

公开(公告)号：US20170072399A1

公开(公告)日：2017-03-16

申请号：US15360691

申请日：2016-11-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Samson CHEN ,  Axel SCHERER ,  Christopher I. WALKER

IPC: B01L7/00 ,  B01L3/00 ,  H05K1/02 ,  C12Q1/68

CPC classification number: B01L7/52 ,  B01L3/502707 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686 ,  H05K1/0212 ,  H05K1/0272 ,  H05K1/028 ,  H05K3/46 ,  H05K3/4697 ,  Y10T29/49124

Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.

Abstract translation: 公开了用于进行聚合酶链式反应（PCR）的PC板流体装置。 这些装置包括印刷电路板和PCR室。 PCR室是流体室，位于PC板中，或者位于PC板的一部分。 PC板可以包括带有温度传感器和控制器的线圈跟踪加热元件。

公开(公告)号：US20150380989A1

公开(公告)日：2015-12-31

申请号：US14840819

申请日：2015-08-31

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Aditya RAJAGOPAL ,  Seheon KIM ,  Andrew P. HOMYK

IPC: H02J17/00 ,  G01J3/02

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes a method for optically powering transducers and related transducers with a photovoltaic collector. An optical fiber power delivery method and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了一种用于利用光伏收集器对换能器和相关换能器进行光学供电的方法。 还提供了光纤功率传递方法和自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。

公开(公告)号：US20140135198A1

公开(公告)日：2014-05-15

申请号：US14062763

申请日：2013-10-24

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Carl J. ALLENDORPH ,  Axel SCHERER

IPC: C12M1/00

CPC classification number: B04B5/0414 ,  B01L3/50215 ,  B04B5/10

Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device has centrifuge tubes and elements to create electric fields. The shear forces applied to the cells inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.

Abstract translation: 公开了基于离心的分子分析方法和装置。 离心机具有离心管和元件以产生电场。 用生物分子施加到溶液中的细胞的剪切力允许执行不同的分析技术，例如用于PCR的裂解和样品制备。

公开(公告)号：US20140072993A1

公开(公告)日：2014-03-13

申请号：US13852476

申请日：2013-03-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Axel SCHERER ,  Michael D. HENRY ,  Sameer WALAVALKAR ,  Thomas A. TOMBRELLO ,  Andrew P. HOMYK

IPC: G01N27/327

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。

公开(公告)号：US20130183676A1

公开(公告)日：2013-07-18

申请号：US13740112

申请日：2013-01-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Aditya RAJAGOPAL ,  Axel SCHERER

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6408

Abstract: A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed.

Abstract translation: 描述了在没有任何滤光器的情况下检测荧光物质或荧光团的寿命的装置和方法。 基于测量的荧光寿命，可以鉴定或测定与荧光团如小有机分子，聚合物，肽，糖和核酸连接的分子或化合物。

公开(公告)号：US20240167105A1

公开(公告)日：2024-05-23

申请号：US18419486

申请日：2024-01-22

Applicant: California Institute of Technology

Inventor： Aditya RAJAGOPAL ,  Mark D. GOLDBERG ,  Erika F. GARCIA ,  Xiomara L. MADERO ,  Thomas A. TOMBRELLO ,  Axel SCHERER

IPC: C12Q1/70 ,  C12Q1/68 ,  C12Q1/6851

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333

Abstract: A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.

公开(公告)号：US20190127799A1

公开(公告)日：2019-05-02

申请号：US16102583

申请日：2018-08-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Emil P. KARTALOV ,  Aditya RAJAGOPAL ,  Axel SCHERER ,  Mark D. GOLDBERG

IPC: C12Q1/6883 ,  C12Q1/70 ,  C12Q1/68 ,  C12Q1/6851

Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.

公开(公告)号：US20150279949A1

公开(公告)日：2015-10-01

申请号：US14720473

申请日：2015-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Aditya RAJAGOPAL ,  Chieh-feng CHANG ,  Oliver PLETTENBURG ,  Stefan PETRY ,  Axel SCHERER ,  Charles L. TSCHIRHART

IPC: H01L29/41 ,  H01L29/735 ,  H01L29/78 ,  H01L29/49 ,  H01L29/45

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

公开(公告)号：US20140234848A1

公开(公告)日：2014-08-21

申请号：US14139808

申请日：2013-12-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Thomas A. TOMBRELLO

IPC: G06F21/60 ,  C12Q1/68

CPC classification number: C12Q1/68 ,  G09C5/00 ,  H04L9/00 ,  C12Q2563/185

Abstract: Novel methods and systems for encoding cryptographic information are disclosed. A message can be encoded through a sequence of nucleic acids by assigning a binary value to a pair of nucleic acids, while other nucleic acids can be used for spacing. Unique organisms can also be used for identification. The nucleic acids can be encapsulated in organic materials such as saccharide-based desiccants.

Abstract translation: 公开了用于编码加密信息的新方法和系统。 可以通过将核苷酸序列分配给一对核酸而通过核酸序列编码消息，而其他核酸可用于间隔。 独特的生物也可以用于鉴定。 核酸可以包封在有机材料如糖基干燥剂中。