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公开(公告)号:US11660066B2
公开(公告)日:2023-05-30
申请号:US16547544
申请日:2019-08-21
Applicant: California Institute of Technology
Inventor: Alaina Ann Brinley Rajagopal , Aditya Rajagopal
CPC classification number: A61B8/0891 , A61B8/14 , A61B8/40 , A61B8/4236 , A61B8/4472 , G01S15/895
Abstract: Some implementations of the disclosure are directed to an ultrasound measurement device including: multiple ultrasound sensors to capture tomographical information of a physiological structure, each ultrasound sensor comprising a transducer having a respective resonant frequency, where each transducer has a frequency response that partially overlaps with a frequency response of another transducer; and a processing device to control and process measurements made by the ultrasound sensors. The device may be incorporated in an adhesive substrate configured to be adhered to a patient's skin in alignment with an artery of the patient. The processing device may use the multiple ultrasound sensors to compute the mean arterial pressure through the artery by performing operations of: measuring a circumference of the artery using the multiple ultrasound sensors; measuring a blood flow velocity using the same ultrasound sensors; and computing the mean arterial pressure using the measured arterial circumference and blood flow velocity.
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公开(公告)号:US20210076954A1
公开(公告)日:2021-03-18
申请号:US17020740
申请日:2020-09-14
Applicant: California Institute of Technology
Inventor: Aditya Rajagopal , Dominic Yurk , Yaser Abu-Mostafa , Alaina Ann Brinley Rajagopal
Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
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公开(公告)号:US10524761B2
公开(公告)日:2020-01-07
申请号:US16038070
申请日:2018-07-17
Applicant: California Institute of Technology
Inventor: Aditya Rajagopal , Alaina Ann Brinley Rajagopal
IPC: A61B7/04 , A61B5/0205 , A61B8/00 , A61B5/00 , G01S15/89 , A61B5/145 , A61B5/08 , A61B5/021 , A61B8/02 , A61B8/06 , A61B8/08
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号:US10052081B2
公开(公告)日:2018-08-21
申请号:US15678789
申请日:2017-08-16
Applicant: California Institute of Technology
Inventor: Aditya Rajagopal , Alaina Ann Brinley Rajagopal
CPC classification number: A61B7/04 , A61B5/0022 , A61B5/02055 , A61B5/021 , A61B5/0816 , A61B5/14532 , A61B5/14542 , A61B5/7253 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/742 , A61B8/02 , A61B8/06 , A61B8/085 , A61B8/4209 , A61B8/4416 , A61B8/4477 , A61B8/461 , A61B8/565 , A61B2560/0214 , G01S15/8952 , G01S15/899
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号:US20240306925A1
公开(公告)日:2024-09-19
申请号:US18429343
申请日:2024-01-31
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor: Aditya RAJAGOPAL , Dominic Yurk , Yaser Abu-Mostafa , Alaina Ann Brinley Rajagopal
CPC classification number: A61B5/02133 , A61B5/6832 , A61B5/7405 , A61B5/02141
Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
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公开(公告)号:US11998383B2
公开(公告)日:2024-06-04
申请号:US16927911
申请日:2020-07-13
Applicant: California Institute of Technology
Inventor: Aditya Rajagopal , Alaina Ann Brinley Rajagopal
IPC: A61B7/04 , A61B5/00 , A61B5/0205 , A61B5/08 , A61B5/145 , A61B8/00 , A61B8/02 , A61B8/06 , A61B8/08 , G01S15/89 , A61B5/021
CPC classification number: A61B7/04 , A61B5/0022 , A61B5/02055 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B8/4416 , A61B8/4477 , G01S15/8952 , G01S15/899 , A61B5/021 , A61B5/0816 , A61B5/14532 , A61B5/14542 , A61B5/7253 , A61B5/742 , A61B8/02 , A61B8/06 , A61B8/085 , A61B8/4209 , A61B8/461 , A61B8/565 , A61B2560/0214
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号:US11950887B2
公开(公告)日:2024-04-09
申请号:US17020740
申请日:2020-09-14
Applicant: California Institute of Technology
Inventor: Aditya Rajagopal , Dominic Yurk , Yaser Abu-Mostafa , Alaina Ann Brinley Rajagopal
CPC classification number: A61B5/02133 , A61B5/6832 , A61B5/7405 , A61B5/02141
Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
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公开(公告)号:US20230240646A1
公开(公告)日:2023-08-03
申请号:US18128998
申请日:2023-03-30
Applicant: California Institute of Technology
Inventor: Alaina Ann Brinley Rajagopal , Aditya Rajagopal
CPC classification number: A61B8/0891 , A61B8/14 , A61B8/40 , A61B8/4236 , A61B8/4472 , G01S15/895
Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits an ultrasound signal that is reflected by the physiological structure to create a reflected ultrasound signal, the first transducer generates a first received signal from the reflected ultrasound signal, the second transducer generates a second received signal from the reflected ultrasound signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
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公开(公告)号:US20200060644A1
公开(公告)日:2020-02-27
申请号:US16547544
申请日:2019-08-21
Applicant: California Institute of Technology
Inventor: Alaina Ann Brinley Rajagopal , Aditya Rajagopal
Abstract: Some implementations of the disclosure are directed to an ultrasound measurement device including: multiple ultrasound sensors to capture tomographical information of a physiological structure, each ultrasound sensor comprising a transducer having a respective resonant frequency, where each transducer has a frequency response that partially overlaps with a frequency response of another transducer; and a processing device to control and process measurements made by the ultrasound sensors. The device may be incorporated in an adhesive substrate configured to be adhered to a patient's skin in alignment with an artery of the patient. The processing device may use the multiple ultrasound sensors to compute the mean arterial pressure through the artery by performing operations of: measuring a circumference of the artery using the multiple ultrasound sensors; measuring a blood flow velocity using the same ultrasound sensors; and computing the mean arterial pressure using the measured arterial circumference and blood flow velocity.
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公开(公告)号:US12102477B2
公开(公告)日:2024-10-01
申请号:US18128998
申请日:2023-03-30
Applicant: California Institute of Technology
Inventor: Alaina Ann Brinley Rajagopal , Aditya Rajagopal
CPC classification number: A61B8/0891 , A61B8/14 , A61B8/40 , A61B8/4236 , A61B8/4472 , G01S15/895
Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits an ultrasound signal that is reflected by the physiological structure to create a reflected ultrasound signal, the first transducer generates a first received signal from the reflected ultrasound signal, the second transducer generates a second received signal from the reflected ultrasound signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
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