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公开(公告)号：US20240360318A1
公开(公告)日：2024-10-31
申请号：US18422568
申请日：2024-01-25
申请人： Enzo Biochem, Inc.
发明人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda , Dee Shen
IPC分类号： C09B23/14 , C07D401/12 , C09B23/01 , C09B23/04 , C09B23/06 , C09B23/10 , G01N33/58 , G01N33/68
CPC分类号： C09B23/145 , C07D401/12 , C09B23/0008 , C09B23/0025 , C09B23/0058 , C09B23/0066 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/141 , G01N33/582 , G01N33/6845 , G01N2458/30 , G01N2800/2821 , G01N2800/2835
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
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公开(公告)号：US11988667B2
公开(公告)日：2024-05-21
申请号：US17105638
申请日：2020-11-27
申请人： FUJIFILM Corporation
发明人： Hiyoku Nakata , Kousuke Watanabe , Akihiro Asakura , Keiko Makita , Yoshinori Kanazawa , Kazuhei Kaneko
CPC分类号： G01N33/582 , C09B23/06 , C09K11/06 , G01N21/6428 , C09K2211/1029 , G01N2021/6439
摘要： Provided are any one of the following fluorescent compounds and a fluorescent labeled biological substance having this fluorescent compound.
X represents CR5 or N, and R1 to R7, Q1, Q2, L1, and L2 each represent a specific group.
a ring β1 and a ring β2 are a 5- to 8-membered ring,
At least one of R1 to R7, L1, L2, Q1, or Q2 has a specific hydrophilic group.
However, in a case where the ring β1 and the ring β2 are a 6-membered ring, and L1 and L2 are an arylene group, R5 is not an aryl group substituted with a linear alkyl group having 18 or more carbon atoms. In addition to the regulation of the ring β1, the ring β2, L1, and L2, in a case where R5 has a substituent having a dipyrromethene boron complex structure, the dipyrromethene boron complex structure has a structure in which a dipyrromethene skeleton is coordinately bonded to a boron atom in the tridentate or tetradentate coordination.-
3.发明授权公开(公告)号：US11965100B2
公开(公告)日：2024-04-23
申请号：US17301941
申请日：2021-04-20
发明人： Benzhong Tang , Ruoyao Zhang
CPC分类号： C09B23/06 , G01N21/6402 , G01N21/6428 , G01N21/6458 , G01N2021/6439 , G01N2201/06113
摘要： Provided herein are aggregation-induced emission luminogens useful for imaging and/or detecting cancer cells and dynamically monitoring the viability of cancer cells and methods of use and preparation thereof.
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公开(公告)号：US20230322987A1
公开(公告)日：2023-10-12
申请号：US18336635
申请日：2023-06-16
申请人： TOPPAN Inc.
发明人： Reiko IWATA , Yuri NAGAI , Akihiro YAMADA , Shuto HARA
IPC分类号： C08F220/32 , C08F220/18 , C08F220/30 , C09B23/04 , C09B23/06 , G02B5/20 , G02B5/22
CPC分类号： C08F220/325 , C08F220/1806 , C08F220/301 , C09B23/04 , C09B23/06 , G02B5/208 , G02B5/223
摘要： A colored resin component includes a colorant having maximum absorbance in a wavelength band of 700 nm or higher and 1100 nm or lower, a copolymer including a first repeating unit derived from an acrylic monomer having an epoxy group, a second repeating unit derived from a monomer having a phenolic hydroxyl group, and a third repeating unit derived from an acrylic monomer having an aromatic ring, or a third repeating unit derived from an acrylic monomer having an alicyclic structure, and a solvent compatible with the colorant and the copolymer.
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公开(公告)号：US11572475B2
公开(公告)日：2023-02-07
申请号：US14233044
申请日：2012-07-18
申请人： Maged Henary , W. David Wilson
发明人： Maged Henary , W. David Wilson
IPC分类号： C09B23/06 , C07D209/14 , C07D403/06 , C07D213/73 , C07D209/49 , C07D403/12 , C07D407/12 , C07D249/10 , C07D231/14 , C07D413/14 , C07D239/34 , C07D231/20 , C07D401/14 , C07D401/04 , C07D403/10 , C07D209/18 , C07D235/24 , C07D417/12 , C07D213/64
摘要： Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.
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公开(公告)号：US11530439B2
公开(公告)日：2022-12-20
申请号：US17191390
申请日：2021-03-03
发明人： Antoine Francais , Xiaohai Liu
IPC分类号： C12Q1/68 , C09B23/06 , C12Q1/6816 , C07D209/08 , C07D403/06 , C09B23/08 , G01N33/58 , C09B23/10
摘要： The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
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公开(公告)号：US20220289981A1
公开(公告)日：2022-09-15
申请号：US17636729
申请日：2020-08-21
发明人： Clay Jeremy CARTER , Adrian HEGEMAN
IPC分类号： C09B23/06 , C07C251/16 , C07C251/30 , C07D207/20 , C07D207/22 , C07D207/44 , C07D209/08 , C07D209/20 , C07D209/42 , C07D233/64 , C07H5/04 , G01N31/22
摘要： The invention provides a compound of formula (I): wherein R1, R2, and R3 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), methods for preparing compounds of formula (I), and methods for detecting the presence of an amine in a sample. The compounds are useful as pigments.
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公开(公告)号：US20200232023A1
公开(公告)日：2020-07-23
申请号：US16545900
申请日：2019-08-20
发明人： Stephen Yue , Gene SHEN , Wei-Chuan (David) SUN
IPC分类号： C12Q1/6869 , C12Q1/6876 , C09B23/10 , C07D401/14 , C07D405/14 , G01N33/58 , C09B23/01 , C09B23/06 , C07D209/14 , C09B23/08 , C07H19/10 , C07K5/09 , C07K5/11 , C12Q1/6844 , C09B23/16 , G01N33/52
摘要： The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
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公开(公告)号：US10513095B2
公开(公告)日：2019-12-24
申请号：US15528632
申请日：2015-10-21
发明人： Mauricio E. Leano , Paul R. Elowe , Mary Anne Leugers , Debkumar Bhattacharjee , Todd O. Pangburn , Bruce Peterson , Matthew Toyli
IPC分类号： B32B27/08 , C09B23/16 , C09B23/00 , C09B23/01 , B32B27/32 , C08J7/04 , B32B7/12 , B32B7/02 , B32B7/10 , B32B9/04 , B32B27/06 , B32B27/16 , B32B27/20 , B32B27/28 , C08L23/08 , C09B23/06 , C09B23/08 , C09B31/068 , B32B25/08
摘要： A shrink film comprising a polyethylene-based film having a top surface, a bottom surface, and comprising one or more layers, wherein at least one layer of the polyethylene-based film comprises a low density polyethylene having a density of from 0.917 g/cc to 0.935 g/cc and melt index, I2, of from 0.1 g/10 min to 5 g/10 min, a linear low density polyethylene having a density of from 0.900 g/cc to 0.965 g/cc and melt index, I2, of from 0.05 g/10 min to 15 g/10 min, or combinations thereof, and optionally, a medium density polyethylene, a high density polyethylene, or combinations thereof, and a coating layer disposed on the top surface of the polyethylene-based film, wherein the coating layer comprises an adhesive and a near-infrared absorbent material.
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公开(公告)号：US10458915B2
公开(公告)日：2019-10-29
申请号：US13898369
申请日：2013-05-20
发明人： Stephen Yue , Gene Shen , Wei-Chuan Sun
IPC分类号： C07D417/04 , G01N21/64 , C07D495/04 , C09B57/00 , C07D487/04 , C09B23/06 , C09B23/08 , C09B23/01
摘要： The present invention provides heteroaryl functionalized cyanine dyes including a reactive functional moiety, or which are conjugated to a carrier molecule.
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