公开(公告)号：US20240360318A1

公开(公告)日：2024-10-31

申请号：US18422568

申请日：2024-01-25

申请人： Enzo Biochem, Inc.

发明人： Wayne Forrest Patton ,  Sergiy M. Yarmoluk ,  Praveen Pande ,  Vladyslava Kovalska ,  Lijun Dai ,  Kateryna Volkova ,  Jack Coleman ,  Mykhaylo Losytskyy ,  Anthony Ludlam ,  Anatoliy Balanda ,  Dee Shen

IPC分类号： C09B23/14 ,  C07D401/12 ,  C09B23/01 ,  C09B23/04 ,  C09B23/06 ,  C09B23/10 ,  G01N33/58 ,  G01N33/68

CPC分类号： C09B23/145 ,  C07D401/12 ,  C09B23/0008 ,  C09B23/0025 ,  C09B23/0058 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/06 ,  C09B23/102 ,  C09B23/141 ,  G01N33/582 ,  G01N33/6845 ,  G01N2458/30 ,  G01N2800/2821 ,  G01N2800/2835

摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.

公开(公告)号：US09932479B2

公开(公告)日：2018-04-03

申请号：US14812171

申请日：2015-07-29

申请人： Enzo Biochem, Inc.

发明人： Wayne Forrest Patton ,  Sergiy M. Yarmoluk ,  Praveen Pande ,  Vladyslava Kovalska ,  Lijun Dai ,  Kateryna Volkova ,  Jack Coleman ,  Mykhaylo Losytskyy ,  Anthony Ludlum ,  Anatoliy Balanda

IPC分类号： C09B23/16 ,  C09B23/14 ,  G01N33/58 ,  G01N33/68 ,  C07D401/12 ,  C09B23/01 ,  C09B23/04 ,  C09B23/06 ,  C09B23/10 ,  C12Q1/68

CPC分类号： C09B23/145 ,  C07D401/12 ,  C09B23/0008 ,  C09B23/0025 ,  C09B23/0058 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/06 ,  C09B23/102 ,  C09B23/141 ,  G01N33/582 ,  G01N33/6845 ,  G01N2458/30 ,  G01N2800/2821 ,  G01N2800/2835

摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

公开(公告)号：US20150376411A1

公开(公告)日：2015-12-31

申请号：US14812171

申请日：2015-07-29

申请人： Enzo Biochem, Inc.

发明人： Wayne Forrest Patton ,  Sergiy M. Yarmoluk ,  Praveen Pande ,  Vladyslava Kovalska ,  Lijun Dai ,  Kateryna Volkova ,  Jack Coleman ,  Mykhaylo Losytskyy ,  Anthony Ludlum ,  Anatoliy Balanda

IPC分类号： C09B23/14 ,  G01N33/58 ,  G01N33/68

CPC分类号： C09B23/145 ,  C07D401/12 ,  C09B23/0008 ,  C09B23/0025 ,  C09B23/0058 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/06 ,  C09B23/102 ,  C09B23/141 ,  G01N33/582 ,  G01N33/6845 ,  G01N2458/30 ,  G01N2800/2821 ,  G01N2800/2835

摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

摘要翻译： 提供了可用于许多应用的染料和组合物，例如检测和监测蛋白质聚集，蛋白质聚集的动力学研究，神经原纤维斑块分析，蛋白质制剂稳定性的评估，蛋白质热稳定性转移测定和分子伴侣活性的分析 。 这些染料和组合物也可用作核酸和蛋白质检测中的探针。