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37 条记录 (耗时 0.015 秒)

    Process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids or carboxylic esters
    2.
    发明授权
    Process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids or carboxylic esters 失效
    制备外消旋烷基-5-卤代-4-烯羧酸或羧酸酯的方法

    公开(公告)号：US07550626B2

    公开(公告)日：2009-06-23

    申请号：US11995553

    申请日：2006-07-03

    申请人： Peter Pojarliev ,  Gerhard Steinbauer ,  Christian Burger

    发明人： Peter Pojarliev ,  Gerhard Steinbauer ,  Christian Burger

    IPC分类号： C07C69/62 ,  C07C53/15

    CPC分类号： C07C51/09 ,  C07C67/32 ,  C07C67/343 ,  C07C57/52 ,  C07C69/65

    摘要： A process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids and esters thereof of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-4-alkyl and X is chlorine, bromine or iodine, which comprises a) reacting a dialkyl alkylmalonate of the formula (II),in which R is as defined above and R2 is a C1-C4-alkyl radical, in the presence of a metal alkoxide of the formula MOR3, in which M may be Na, K or Li, and R3 is a C1-C4-alkyl radical, and in an organic solvent, with 1,3-dihalopropene to give the corresponding allylated malonate, then b) after full conversion, adding an inorganic salt and a C1-C6 alcohol to the reaction mixture, heating the reaction mixture to reflux temperature, then c) isolating the desired racemic ester of the formula (I) from the reaction mixture by extraction or direct distillation and d) if the racemic acid is the desired end product, hydrolyzing the ester function.

    摘要翻译： 制备式（I）的外消旋烷基-5-卤代-4-甲酸及其酯的方法，其中R是C1-C6-烷基，R1是H或C1-4 - 烷基，X是氯 溴或碘，其包括：a）在式MOR 3的金属醇盐存在下使式（II）的烷基丙二酸二烷基酯（其中R如上定义，R 2是C 1 -C 4 - 烷基） 其中M可以是Na，K或Li，R3是C1-C4-烷基，在有机溶剂中与1,3-二卤丙烯反应，得到相应的烯丙基化丙二酸酯，然后b）完全转化后，加入 无机盐和C 1 -C 6醇反应混合物，将反应混合物加热至回流温度，然后c）通过萃取或直接蒸馏从反应混合物中分离所需的式（I）外消旋酯，和d）如果外消旋 酸是所需的最终产物，水解酯的功能。

    Process for preparing fluorocarboxylic acids
    4.
    发明授权
    Process for preparing fluorocarboxylic acids 有权
    制备氟代羧酸的方法

    公开(公告)号：US07253315B2

    公开(公告)日：2007-08-07

    申请号：US11088370

    申请日：2005-03-24

    申请人： Ta-Wei Fu ,  Steven H. Swearingen ,  Takuya Ichida ,  Shigeyuki Yoshii

    发明人： Ta-Wei Fu ,  Steven H. Swearingen ,  Takuya Ichida ,  Shigeyuki Yoshii

    IPC分类号： C07C53/15 ,  C07C51/58

    CPC分类号： C07C51/04 ,  C07C51/48 ,  C07C59/135 ,  C07C53/21

    摘要： A fluorocarboxylic acid preparation process which includes hydrolyzing fluorocarboxylic acid fluoride in the presence of an aqueous sulfuric acid solution to form a reaction product containing a fluorocarboxylic acid and hydrogen fluoride (present as hydrofluoric acid); and removing at least some of the hydrogen fluoride from the reaction product by washing the reaction production with aqueous sulfuric acid solution. The hydrolyzing and washing are carried out at a temperature at which the fluorocarboxylic acid is a liquid.

    摘要翻译： 一种氟代羧酸制备方法，其包括在硫酸水溶液存在下水解氟代羧酸，形成含有氟代羧酸和氟化氢（以氢氟酸形式存在）的反应产物; 并通过用硫酸水溶液洗涤反应生成，从反应产物中除去至少一些氟化氢。 水解和洗涤在氟代羧酸是液体的温度下进行。

    Alkanoic acid derivatives
    7.
    发明授权
    Alkanoic acid derivatives 失效
    烷酸衍生物

    公开(公告)号：US07217409B2

    公开(公告)日：2007-05-15

    申请号：US10381116

    申请日：2001-09-21

    申请人： Brian Edgar Looker ,  Christopher James Lunniss ,  Alison Judith Redgrave ,  Derek Peter Reynolds

    发明人： Brian Edgar Looker ,  Christopher James Lunniss ,  Alison Judith Redgrave ,  Derek Peter Reynolds

    IPC分类号： A61K51/00 ,  C07C53/15

    CPC分类号： C07C69/708 ,  C07C51/09 ,  C07C59/125 ,  C07C59/135 ,  Y10S514/958

    摘要： A method for treating respiratory disorders comprises administering to a patient a pharmaceutical aerosol formulation comprising: (i) a compound of formula (I) or a salt or solvate thereof, wherein: n represents an integer 1 to 6; N represents an integer 1 to 15; R1 represents —(CO)xC1-9 alkyl or —(CO)xC1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1; and R2 and R3 independently represent C1-3alkyl or hydrogen, (ii) at least one medicament, and (iii) at least one propellant.

    摘要翻译： 治疗呼吸系统疾病的方法包括向患者施用药物气溶胶制剂，其包含：（i）式（I）化合物或其盐或溶剂合物，其中：n表示1至6的整数; N表示1〜15的整数， R 1表示 - （CO）1 -C 14烷基或 - （CO）x C C 氟代烷基部分含有至少1个氟原子和不多于3个连续的全氟化碳原子，其中x表示0或1; R 2和R 3独立代表C 1-3烷基或氢，（ii）至少一种药物，和（iii）在 至少一个推进剂。

    Perfluoro intermediates and processes for their preparation
    9.
    发明授权
    Perfluoro intermediates and processes for their preparation 失效
    全氟中间体及其制备方法

    公开(公告)号：US4246200A

    公开(公告)日：1981-01-20

    申请号：US43042

    申请日：1979-05-29

    申请人： Claude Wakselman ,  Marc Tordeux

    发明人： Claude Wakselman ,  Marc Tordeux

    IPC分类号： C07C257/02 ,  C07C53/15 ,  C07C67/00 ,  C07C233/01 ,  C07C241/00 ,  C07C119/00

    CPC分类号： C07C251/00

    摘要： This invention relates to compounds having the formula ##STR1## in which R.sub.F is a perfluoro radical C.sub.n F.sub.2n+1 with n=1-20, and R is a C.sub.1-20 alkyl radical, a C.sub.4-15 cycloalkyl radical, a C.sub.5-20 cycloalkyl-alkyl radical, or a C.sub.6-20 aromatic radical.Said compounds constitute valuable intermediates for the synthesis of surface-active agents.

    摘要翻译： 本发明涉及具有式“IMAGE”的化合物，其中RF是具有n = 1-20的全氟自由基CnF2n + 1，R是C1-20烷基，C4-15环烷基，C5-20环烷基 - 烷基或C6-20芳族基团。 所述化合物构成用于合成表面活性剂的有价值的中间体。