公开(公告)号：US12091377B2

公开(公告)日：2024-09-17

申请号：US17295120

申请日：2019-10-31

申请人： Dow Global Technologies LLC ,  Dow Portugal Produtos Quimicos, Sociedade Unipessoal, LDA

发明人： Robert E. Hefner, Jr. ,  Helge Braun ,  Armenio Costa ,  Brian Cramm

IPC分类号： C07C273/18 ,  B01J31/22

CPC分类号： C07C273/1818 ,  B01J31/2234 ,  B01J31/2295 ,  C07C273/1809 ,  C07C273/1872 ,  B01J2531/22 ,  B01J2531/845 ,  C07C273/1809 ,  C07C275/28 ,  C07C273/1818 ,  C07C275/28 ,  C07C273/1872 ,  C07C275/28

摘要： Organic isocyanates are converted to ureas by heating in the presence of certain cobalt, magnesium, chromium and lanthanide series organometallic catalysts. The process requires no water or other reactants. The process is particularly useful for removing small quantities of monoisocyanates from a solvent stream recovered from a polyisocyanate manufacturing process. The urea compounds in some instances can be recycled back into the polyisocyanate manufacturing process and reacted with polyisocyanate compounds to form biurets.

公开(公告)号：US11912644B2

公开(公告)日：2024-02-27

申请号：US17978734

申请日：2022-11-01

申请人： Celgene Corporation

发明人： John F. Traverse ,  Michael J. Zacuto ,  Weihong Zhang ,  Kirsten Faye Johnson ,  Maryll E. Geherty ,  Christopher Marton

IPC分类号： C07C231/18 ,  C07C231/12 ,  C07C237/06 ,  C07D209/46 ,  C07C275/70 ,  C07C237/12 ,  C07C273/18 ,  C07C275/24 ,  C07C67/313 ,  C07C231/02

CPC分类号： C07C231/18 ,  C07C67/313 ,  C07C231/02 ,  C07C231/12 ,  C07C237/06 ,  C07C237/12 ,  C07C273/1809 ,  C07C275/24 ,  C07C275/70 ,  C07D209/46 ,  C07C67/313 ,  C07C69/84 ,  C07C273/1809 ,  C07C275/06 ,  C07C231/12 ,  C07C237/06

摘要： Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

公开(公告)号：US11724982B2

公开(公告)日：2023-08-15

申请号：US16868343

申请日：2020-05-06

申请人： Ming-Yu Ngai ,  Katarzyna N. Hojczyk

发明人： Ming-Yu Ngai ,  Katarzyna N. Hojczyk

IPC分类号： C07C233/25 ,  C07C259/06 ,  C07C259/10 ,  C07C269/06 ,  C07C273/18 ,  C07C231/14 ,  C07C253/30 ,  C07D213/75 ,  C07D213/76 ,  C07D347/00 ,  C07D239/47 ,  C07D239/91 ,  C07D473/40 ,  C07D263/57 ,  C07D209/08 ,  C07D215/40 ,  C07D401/04 ,  C07D471/04 ,  C07J43/00 ,  C07D417/04 ,  C07D405/04 ,  C07C231/12 ,  C07C233/33 ,  C07C233/54 ,  C07C233/80 ,  C07C233/81 ,  C07C255/60 ,  C07C255/58 ,  C07C271/38 ,  C07C275/34

CPC分类号： C07C233/25 ,  C07C231/12 ,  C07C231/14 ,  C07C233/33 ,  C07C233/54 ,  C07C233/80 ,  C07C233/81 ,  C07C253/30 ,  C07C255/58 ,  C07C255/60 ,  C07C259/06 ,  C07C259/10 ,  C07C269/06 ,  C07C271/38 ,  C07C273/1809 ,  C07C273/1854 ,  C07C275/34 ,  C07D209/08 ,  C07D213/75 ,  C07D213/76 ,  C07D215/40 ,  C07D239/47 ,  C07D239/91 ,  C07D263/57 ,  C07D347/00 ,  C07D401/04 ,  C07D405/04 ,  C07D417/04 ,  C07D471/04 ,  C07D473/40 ,  C07J43/003 ,  C07C273/1854 ,  C07C275/64 ,  C07C269/06 ,  C07C271/38 ,  C07C231/14 ,  C07C233/25 ,  C07C253/30 ,  C07C255/60 ,  C07C253/30 ,  C07C255/58 ,  C07C273/1809 ,  C07C275/34

摘要： The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure:




wherein

A is an aryl or heteroaryl, each with or without substitution; and

R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising:

(a) reacting a compound having the structure:





with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure:





and

(b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:

公开(公告)号：US20230068165A1

公开(公告)日：2023-03-02

申请号：US17877083

申请日：2022-07-29

申请人： North Carolina State University

发明人： Jun Ohata ,  Hisham El-Shaffey ,  Elizabeth Jasmine Gross ,  Yvonne Hall

IPC分类号： C07C273/18

摘要： The use of ionic liquids as a solvent for chemoselective bioconjugation reactions is described. For example, methods of preparing bioconjugates in ionic liquids via a phosphine-mediated azide-amine reaction to form a urea linkage between a biomolecule substrate and a second molecule are described. Methods of preparing bioconjugates with amide or enamine linkages in ionic liquids are also described. The methods can be used to prepare tagged biomolecules, such as dye-tagged proteins, peptides, nucleic acids, or saccharides (e.g., aminosaccharides), for use in various applications; to form biomolecule-polymer conjugates; or to form biomolecule-therapeutic agent conjugates, such as antibody-drug conjugates.

公开(公告)号：US20210403418A1

公开(公告)日：2021-12-30

申请号：US17288967

申请日：2019-07-31

申请人： Dow Global Technologies LLC ,  Dow Portugal Produtos Quimicos, Sociedade Unipessoal, LDA

发明人： Robert E. Hefner, Jr. ,  Helge Braun ,  Armenio Costa ,  Brian Cramm

IPC分类号： C07C263/10 ,  C07C273/18 ,  C08G18/76

摘要： Monoisocyanate impurities are removed from a process stream obtained when solvent is separated from a polyisocyanate product. The monoisocyanates are reacted with amine compounds at specific molar ratios to produce ureas. The ureas can be discarded by burning, landfilling or otherwise. Alternatively the ureas can be recycled back into the polyisocyanate manufacturing process, where they are formed into biuret compounds that can remain with the polyisocyanate product.

公开(公告)号：US11155509B2

公开(公告)日：2021-10-26

申请号：US16591596

申请日：2019-10-02

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Michael S. Strano ,  Seonyeong Kwak ,  Dorsa Parviz ,  Daniel James Lundberg

IPC分类号： C08J7/12 ,  C07C45/00 ,  C12P7/24 ,  C08G65/16 ,  C07C273/18

摘要： A composition can photocatalytically reduce carbon dioxide.

公开(公告)号：US20200148610A1

公开(公告)日：2020-05-14

申请号：US16742523

申请日：2020-01-14

申请人： AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

发明人： Wilfried BRAJE ,  Katarina BRITZE ,  Justin D. DIETRICH ,  Anais JOLIT ,  Johannes KASCHEL ,  Johanna KLEE ,  Tanja LINDNER

IPC分类号： C07B63/04 ,  C07B37/04 ,  C07B43/04 ,  C07F5/02 ,  C07B43/06 ,  C07D495/04 ,  C07D471/04 ,  C07D409/04 ,  C07D405/04 ,  C07D311/58 ,  C07D307/81 ,  C07D307/36 ,  C07D239/42 ,  C07D239/26 ,  C07D215/227 ,  C07D213/74 ,  C07D211/06 ,  C07D209/48 ,  C07D209/08 ,  C07D207/34 ,  C07D205/04 ,  C07C319/26 ,  C07C303/42 ,  C07C273/18 ,  C07C269/08 ,  C07C253/32 ,  C07C231/22 ,  C07C213/10 ,  C07C209/90 ,  C07C67/62 ,  C07C41/46

摘要： The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.

公开(公告)号：US10519104B2

公开(公告)日：2019-12-31

申请号：US15444776

申请日：2017-02-28

申请人： NerPharMa S.r.l.

发明人： Attilio Tomasi ,  Ilaria Candiani ,  Francesco Corcella ,  Francesco Saverio Caldarelli

IPC分类号： C07C273/18 ,  C07C275/08 ,  C07C275/68 ,  C07D233/60

摘要： Carmustine may be safely and efficiently produced by reacting 2-chloroethylamine hydrochloride and 1,1′-carbonyldiimidazole to afford 1,3-bis(2-chloroethyl)-1-urea, followed by nitrosation to give the final product.

公开(公告)号：US10106494B2

公开(公告)日：2018-10-23

申请号：US15101396

申请日：2013-12-02

申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC

发明人： Georgius Abidal Adam

IPC分类号： C07C211/09 ,  C07C211/63 ,  C07C215/14 ,  C07C215/40 ,  C07C229/16 ,  C07C273/18 ,  C07C275/14 ,  C07C275/46 ,  C07C275/62 ,  C07C271/54 ,  C07C213/06 ,  C07C217/54 ,  C07D251/70

摘要： Disclosed herein are gemini surfactants, and methods for making and using these gemini surfactants. These gemini surfactants may be incorporated in paints and coatings to provide hydrophilic and/or self-cleaning properties.

公开(公告)号：US20180186731A1

公开(公告)日：2018-07-05

申请号：US15653591

申请日：2017-07-19

申请人： Great Eastern Resins Industrial Co., Ltd.

发明人： Shenghong A. DAI ,  Ching Hsuan LIN ,  Jung-Yang YANG

IPC分类号： C07C269/04 ,  C08G69/00 ,  C07C263/04 ,  C07C267/00 ,  C07C273/18 ,  C07C231/10

CPC分类号： C07C269/04 ,  C07C231/10 ,  C07C263/04 ,  C07C267/00 ,  C07C273/1809 ,  C08G69/00 ,  C08G69/04 ,  C08G69/26 ,  C08G69/28 ,  C08G69/32 ,  C07C271/58

摘要： The present invention is directed to a process for preparing amides or polyamides by replacing isocyanate starting materials of a catalyzed thermal reaction with aromatic carbamates. Through the catalyzed thermal process involving a non-isocyanate precursor of the present invention, efficiency for producing amides or polyamides can be significantly improved, and the impure side products produced from a side reaction of isocyanate can be greatly curtailed. Hence, amides or polyamides of high purity and yield can be achieved. The invention also relates to a process for preparing aromatic carbamates, the new non-isocyanate precursors for amides or polyamides.