公开(公告)号：US20180050000A1

公开(公告)日：2018-02-22

申请号：US15583697

申请日：2017-05-01

Applicant: Pathologica LLC

Inventor： John MCKEARN ,  Jeremy BLITZER

IPC: A61K31/155 ,  A61K9/48 ,  C07C251/12 ,  C07C251/78 ,  C07C243/16 ,  C07C211/13 ,  A61K9/28 ,  A61K9/50 ,  A61K9/20

CPC classification number: A61K31/155 ,  A61K9/2054 ,  A61K9/2846 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/4891 ,  A61K9/5026 ,  A61K9/5047 ,  C07C211/13 ,  C07C243/16 ,  C07C251/12 ,  C07C251/78

Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.

公开(公告)号：US09603819B2

公开(公告)日：2017-03-28

申请号：US14635311

申请日：2015-03-02

Applicant: NOVARTIS AG

Inventor： Gary Mark Coppola ,  Yuki Iwaki ,  Rajeshri Karki ,  Toshio Kawanami ,  Gary Michael Ksander ,  Muneto Mogi ,  Robert Sun

IPC: A61K31/194 ,  C07C233/47 ,  C07C233/63 ,  C07C233/87 ,  C07C235/52 ,  C07C251/12 ,  C07C257/06 ,  C07C271/12 ,  C07C275/16 ,  C07C311/19 ,  C07C317/44 ,  C07C235/82 ,  C07D207/34 ,  C07D209/18 ,  C07D213/56 ,  C07D213/81 ,  C07D213/82 ,  C07D231/14 ,  C07D239/28 ,  C07D271/10 ,  C07D277/64 ,  C07D285/12 ,  C07D303/48 ,  C07D307/68 ,  C07D309/40 ,  C07D333/24 ,  C07D333/40 ,  C07D261/18 ,  A61K45/06 ,  C07C235/74

CPC classification number: A61K31/194 ,  A61K45/06 ,  C07C233/47 ,  C07C233/63 ,  C07C233/87 ,  C07C235/52 ,  C07C235/74 ,  C07C235/82 ,  C07C251/12 ,  C07C257/06 ,  C07C271/12 ,  C07C275/16 ,  C07C311/19 ,  C07C317/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07D207/34 ,  C07D209/18 ,  C07D213/56 ,  C07D213/81 ,  C07D213/82 ,  C07D231/14 ,  C07D239/28 ,  C07D261/18 ,  C07D271/10 ,  C07D277/64 ,  C07D285/12 ,  C07D303/48 ,  C07D307/68 ,  C07D309/40 ,  C07D333/24 ,  C07D333/40

Abstract: The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20160159742A1

公开(公告)日：2016-06-09

申请号：US15040577

申请日：2016-02-10

Applicant: Dow AgroSciences LLC

Inventor： Natalie C. Giampietro ,  James M. Renga

IPC: C07D213/79 ,  C07C251/12

CPC classification number: C07D213/79 ,  C07C251/12 ,  C07D213/803

Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a C1-C4 alkyl propiolate and a substituted methylene amine by a series of steps.

Abstract translation: 4-氨基-5-氟-3-氯-6-（取代的）吡啶甲酸盐通过一系列步骤由三氟乙酸，对甲氧基苯胺，C 1 -C 4烷基丙炔酸酯和取代的亚甲基胺制备。

公开(公告)号：US20050267305A1

公开(公告)日：2005-12-01

申请号：US11013774

申请日：2004-12-16

Applicant: Alexander Bradley ,  David Thorn

Inventor： Alexander Bradley ,  David Thorn

IPC: C07C249/02 ,  C07C251/12 ,  C07C251/16 ,  C07D213/74 ,  C07F1/08 ,  C23C16/18 ,  H01L21/285 ,  C07D213/26

CPC classification number: C07D213/74 ,  C07C251/12 ,  C07C251/16 ,  C23C16/18 ,  C23C16/45525 ,  C23C16/45553 ,  H01L21/288 ,  H01L21/3141 ,  Y10T428/31504

Abstract: The present invention relates to a process for the synthesis of novel 1,3-diimine copper complexes using amino-imines and novel amino-imines.

Abstract translation: 本发明涉及使用氨基亚胺和新型氨基亚胺合成新的1,3-二亚胺铜络合物的方法。

公开(公告)号：US6008190A

公开(公告)日：1999-12-28

申请号：US570761

申请日：1995-12-12

Applicant: Thomas J. Meade ,  Toshihiko Takeuchi ,  Harry B. Gray ,  Melvin Simon ,  Angelique Y. Louie

Inventor： Thomas J. Meade ,  Toshihiko Takeuchi ,  Harry B. Gray ,  Melvin Simon ,  Angelique Y. Louie

IPC: C12N9/99 ,  A61K31/295 ,  A61K31/555 ,  A61K38/00 ,  A61P43/00 ,  C07C251/10 ,  C07C251/12 ,  C07C251/16 ,  C07F15/06 ,  C07H21/00 ,  A61K31/70 ,  A61K38/02

CPC classification number: C07H21/00 ,  C07C251/12 ,  C07C251/16 ,  C07F15/065 ,  Y10S424/06

Abstract: The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of hydrogen, alkyl, hydrophilic organic acid, alkyl amine, amine, alkyl alcohol, alcohol, polypeptide or nucleic acid. The invention further relates to methods of using such compounds to reduce the biological activity of proteins, particularly enzymes and zinc finger-containing proteins.

Abstract translation: 本发明涉及具有通式结构的新型钴化合物，其中Co是Co（II）或Co（III），并且每个R基团选自氢，烷基，亲水有机酸，烷基胺， 胺，烷基醇，醇，多肽或核酸。 本发明还涉及使用这些化合物降低蛋白质，特别是酶和含锌指蛋白质的生物学活性的方法。

公开(公告)号：US5623084A

公开(公告)日：1997-04-22

申请号：US443645

申请日：1995-05-18

Applicant: Peter G. Ruminski

Inventor： Peter G. Ruminski

IPC: A01N33/04 ,  A01N33/06 ,  A01N33/12 ,  A01N33/18 ,  A01N33/26 ,  A01N35/10 ,  A01N37/06 ,  A01N37/12 ,  A01N37/18 ,  A01N37/20 ,  A01N37/22 ,  A01N37/26 ,  A01N37/28 ,  A01N37/30 ,  A01N37/38 ,  A01N37/40 ,  A01N37/44 ,  A01N37/46 ,  A01N37/52 ,  A01N41/06 ,  A01N41/12 ,  A01N43/10 ,  A01N43/28 ,  A01N43/36 ,  A01N43/56 ,  A01N43/90 ,  A01N47/12 ,  A01N47/28 ,  A01N47/34 ,  A01N47/40 ,  A01N47/44 ,  A01P5/00 ,  A01P7/00 ,  C07C57/52 ,  C07C57/76 ,  C07C69/65 ,  C07C203/04 ,  C07C205/03 ,  C07C205/09 ,  C07C205/43 ,  C07C209/62 ,  C07C209/64 ,  C07C211/24 ,  C07C211/45 ,  C07C211/48 ,  C07C211/63 ,  C07C219/08 ,  C07C229/12 ,  C07C229/24 ,  C07C229/56 ,  C07C229/60 ,  C07C233/09 ,  C07C233/12 ,  C07C233/13 ,  C07C233/38 ,  C07C233/49 ,  C07C233/55 ,  C07C237/06 ,  C07C237/20 ,  C07C237/22 ,  C07C237/24 ,  C07C239/10 ,  C07C243/10 ,  C07C243/16 ,  C07C243/30 ,  C07C243/34 ,  C07C243/38 ,  C07C251/12 ,  C07C251/24 ,  C07C259/06 ,  C07C265/06 ,  C07C271/20 ,  C07C271/22 ,  C07C275/20 ,  C07C275/64 ,  C07C279/06 ,  C07C309/66 ,  C07C309/73 ,  C07C311/16 ,  C07C311/58 ,  C07C323/60 ,  C07C327/22 ,  C07C327/30 ,  C07C327/32 ,  C07D207/16 ,  C07D231/20 ,  C07D295/185 ,  C07D317/24 ,  C07D333/38 ,  C07D487/18 ,  C07C309/67

CPC classification number: C07D295/185 ,  A01N33/04 ,  A01N33/06 ,  A01N33/18 ,  A01N33/26 ,  A01N35/10 ,  A01N37/06 ,  A01N37/12 ,  A01N37/18 ,  A01N37/20 ,  A01N37/22 ,  A01N37/26 ,  A01N37/28 ,  A01N37/30 ,  A01N37/38 ,  A01N37/40 ,  A01N37/44 ,  A01N37/46 ,  A01N37/52 ,  A01N41/06 ,  A01N41/12 ,  A01N43/10 ,  A01N43/28 ,  A01N43/36 ,  A01N43/56 ,  A01N43/90 ,  A01N47/12 ,  A01N47/28 ,  A01N47/34 ,  A01N47/40 ,  A01N47/44 ,  C07C203/04 ,  C07C205/03 ,  C07C205/09 ,  C07C205/43 ,  C07C211/24 ,  C07C211/48 ,  C07C211/63 ,  C07C219/08 ,  C07C229/12 ,  C07C229/24 ,  C07C229/56 ,  C07C229/60 ,  C07C233/09 ,  C07C233/13 ,  C07C233/38 ,  C07C233/49 ,  C07C233/55 ,  C07C237/06 ,  C07C237/20 ,  C07C237/22 ,  C07C237/24 ,  C07C239/10 ,  C07C243/10 ,  C07C243/16 ,  C07C243/30 ,  C07C243/34 ,  C07C243/38 ,  C07C251/24 ,  C07C259/06 ,  C07C265/06 ,  C07C271/20 ,  C07C271/22 ,  C07C275/20 ,  C07C275/64 ,  C07C279/06 ,  C07C309/66 ,  C07C309/73 ,  C07C311/16 ,  C07C311/58 ,  C07C323/60 ,  C07C327/22 ,  C07C327/30 ,  C07C327/32 ,  C07C57/52 ,  C07C57/76 ,  C07D207/16 ,  C07D231/20 ,  C07D317/24 ,  C07D333/38 ,  C07C2101/02

Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-l-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful for systemic control of pests. Novel method and intermediates for the preparation of 3,4,4-trifluoro-3-butene-1-amine are also provided.

Abstract translation: 氟化烯烃化合物可用于控制在农作物上捕获的线虫，昆虫和螨虫的方法。 极性化合物，例如3,4,4-三氟-3-丁烯-1-胺或3,4,4-三氟-3-丁烯酸，特别适用于系统性控制害虫。 还提供了用于制备3,4,4-三氟-3-丁烯-1-胺的新方法和中间体。

公开(公告)号：US5494975A

公开(公告)日：1996-02-27

申请号：US466870

申请日：1995-06-06

Applicant: Alvin C. Lavoie ,  Daniel A. Bors ,  Ward T. Brown

Inventor： Alvin C. Lavoie ,  Daniel A. Bors ,  Ward T. Brown

IPC: C07C229/30 ,  C07C251/12 ,  C08F8/00 ,  C08F8/32

CPC classification number: C07C251/12 ,  C07C229/30 ,  C08F8/30 ,  C08F8/32 ,  C08F2800/20

Abstract: The present invention relates to the preparation of polymers bearing reactive functional groups. More particularly, this invention relates to the preparation of polymers containing functional acetoacetate groups and then following the polymerization reacting the acetoacetate group with a functional amine to form an enamine.Polymers of the present invention have many uses including coatings, sealants, adhesives and saturant applications, and are most useful as solutions or dispersions in water or water-cosolvent mixtures.

公开(公告)号：US5410056A

公开(公告)日：1995-04-25

申请号：US178195

申请日：1994-01-06

Applicant: Christof Wehrli

Inventor： Christof Wehrli

IPC: B01J27/02 ,  C07B61/00 ,  C07C251/12 ,  C07C251/24 ,  C07D475/04

CPC classification number: C07D475/04 ,  C07C251/12

Abstract: The present invention is directed to a novel process for the production of folic acid in high yield utilizing a novel diimine as an intermediate. This diimine is formed by reacting 2-substituted malondialdehyde with p-aminobenzoyl-L-glutamic acid. This diimine may be converted into folic acid by reacting said diimine with triaminopyrimidinone in the presence of sulphite.

Abstract translation: 本发明涉及以新产物二亚胺为中间体以高产率生产叶酸的新方法。 该二亚胺通过2-取代丙二醛与对氨基苯甲酰基-L-谷氨酸反应形成。 在亚硫酸盐存在下，所述二亚氨基与三氨基嘧啶酮反应可将该二亚胺转化为叶酸。

公开(公告)号：US5245060A

公开(公告)日：1993-09-14

申请号：US849967

申请日：1992-03-12

Applicant: Kimio Hamamura ,  Yoshio Urawa ,  Yukio Narabe ,  Yoshihiko Hisatake ,  Shizumasa Kijima

Inventor： Kimio Hamamura ,  Yoshio Urawa ,  Yukio Narabe ,  Yoshihiko Hisatake ,  Shizumasa Kijima

IPC: B01J31/12 ,  C07B61/00 ,  C07C249/02 ,  C07C251/12

CPC classification number: C07C251/12 ,  C07C2101/14

Abstract: A terpene derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl group; R.sup.2 represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a heteroaryl group; n is 0 or 1 or 2; and the symbol " " represents a single or double bond with the proviso that both of the linkages adjacent to each other are not simultaneously single bonds or double bonds which are useful for the preparation of drug, food, perfume and so on, and a process for preparing thereof.

公开(公告)号：US20200062687A1

公开(公告)日：2020-02-27

申请号：US16466084

申请日：2017-12-22

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Maureen Blandino ,  Michael E. Lankin

IPC: C07C57/03 ,  C07C251/12 ,  C07C255/07 ,  A23L2/56 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  A61Q13/00

Abstract: The present disclosure is directed to the synthesis and application of ethyl linalool derivatives having unique and desired flavor and/or fragrance characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.