公开(公告)号：US20240335592A1

公开(公告)日：2024-10-10

申请号：US18743016

申请日：2024-06-13

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Sichang Lu ,  Madison A.P. McGough ,  Katarzyna J. Zienkiewicz

IPC分类号： A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C04B111/00 ,  C08G18/10 ,  C08G18/38 ,  C08G18/48 ,  C08G18/77 ,  C08G18/80

CPC分类号： A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C08G18/10 ,  C08G18/3868 ,  C08G18/4833 ,  C08G18/771 ,  C08G18/8061 ,  A01K2207/20 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  C04B2111/00836

摘要： A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.

公开(公告)号：US20240335586A1

公开(公告)日：2024-10-10

申请号：US18681443

申请日：2022-08-02

申请人： Amrita Vishwa Vidyapeetham

发明人： Binulal Nelson Sathy ,  Shantikumar Nair ,  Niji Nandakumar

IPC分类号： A61L27/26 ,  A61L27/22 ,  A61L27/44 ,  A61L27/46 ,  A61L27/56 ,  D01D5/00

CPC分类号： A61L27/26 ,  A61L27/222 ,  A61L27/227 ,  A61L27/446 ,  A61L27/46 ,  A61L27/56 ,  D01D5/0038 ,  A61L2300/252

摘要： The present invention discloses a highly stretchable matrix, comprising mesh of lattice structures of microfibrillar filaments, having pore size enlargeable up to 8 times by moving the microfibrillar filaments perpendicular to the longitudinal axis of the microfibrillar filaments without losing its integrity. The invention also pertains to a method of preparing said highly stretchable matrix comprising the steps of: electrostatic spinning of the polymeric solution as microfibers, creating an air-flow at the inter-phase of microfibers to completely eliminate the solvent from the surface of the microfibers bundles to avoid inter-fibrillar bonding after collection and dispersing the microfibers in a direction perpendicular to the longitudinal axis of the fibers, 6-12 times the original width using a dispersion unit to obtain a stretch responsive fibrillar matrix.

公开(公告)号：US12076463B2

公开(公告)日：2024-09-03

申请号：US17849893

申请日：2022-06-27

申请人： DSM IP Assets B.V. ,  ACADEMISCH ZIEKENHUIS MAASTRICHT

发明人： Jens Christoph Thies ,  Ruud Jozef Regina Wilhelmus Peters ,  Pieter J. Emans ,  Jacob Koenen

IPC分类号： A61L27/46 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  C08L75/04

CPC分类号： A61L27/46 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/02 ,  C08L75/04

摘要： The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.

公开(公告)号：US12048779B2

公开(公告)日：2024-07-30

申请号：US17506831

申请日：2021-10-21

申请人： The Trustees of Columbia University in the City of New York

发明人： Sarindr Bhumiratana ,  Gordana Vunjak-Novakovic

IPC分类号： A61L27/36 ,  A61F2/30 ,  A61L27/38 ,  A61L27/42 ,  A61L27/46 ,  A61L27/50 ,  A61L27/56

CPC分类号： A61L27/3612 ,  A61F2/30756 ,  A61L27/3608 ,  A61L27/3834 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61L27/56 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2/3094 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/10 ,  A61L27/46 ,  C08L89/06

摘要： Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

公开(公告)号：US12048633B2

公开(公告)日：2024-07-30

申请号：US17519336

申请日：2021-11-04

申请人： HAPPE SPINE, LLC

发明人： Ryan K. Roeder ,  Gabriel L. Converse ,  Stephen M. Smith

IPC分类号： A61F2/44 ,  A61F2/28 ,  A61L27/12 ,  A61L27/18 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  B29C67/20 ,  C08J9/00 ,  C08J9/28 ,  C08J9/36 ,  A61F2/30

CPC分类号： A61F2/4455 ,  A61F2/28 ,  A61F2/4465 ,  A61L27/12 ,  A61L27/18 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  B29C67/202 ,  C08J9/0066 ,  C08J9/28 ,  C08J9/36 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30006 ,  A61F2002/30011 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30225 ,  A61F2002/30235 ,  A61F2002/30622 ,  A61F2002/30904 ,  A61F2002/3092 ,  A61F2002/30957 ,  A61F2/30965 ,  A61F2210/0004 ,  A61F2210/0071 ,  A61F2230/0069 ,  A61F2250/0015 ,  A61F2250/0018 ,  A61F2250/0023 ,  A61F2250/0031

摘要： A composite material for use, for example, as an orthopedic implant, that includes a porous reinforced composite scaffold that includes a polymer, reinforcement particles distributed throughout the polymer, and a substantially continuously interconnected plurality of pores that are distributed throughout the polymer, each of the pores in the plurality of pores defined by voids interconnected by struts, each pore void having a size within a range from about 10 to 500 nm. The porous reinforced composite scaffold has a scaffold volume that includes a material volume defined by the polymer and the reinforcement particles, and a pore volume defined by the plurality of pores. The reinforcement particles are both embedded within the polymer and exposed on the struts within the pore voids. The polymer may be a polyaryletherketone polymer and the reinforcement particles may be anisometric calcium phosphate particles.

公开(公告)号：US11992581B2

公开(公告)日：2024-05-28

申请号：US16376552

申请日：2019-04-05

申请人： HISTOGRAFT, LLC

发明人： Roman Vadimovich Deev ,  Artur Aleksandrovich Isaev ,  Ilya Yadigerovich Bozo ,  Vladimir Sergeevich Komlev

IPC分类号： A61L27/54 ,  A61K48/00 ,  A61L27/12 ,  A61L27/18 ,  A61L27/36 ,  A61L27/46 ,  C12Q1/6834

CPC分类号： A61L27/54 ,  A61K48/00 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3608 ,  A61L27/46 ,  C12Q1/6834 ,  A61L2300/414 ,  A61L2430/02

摘要： Provided are gene-activated materials comprising a scaffold and at least one nucleic acid molecule which may be chemical bound together or in which the at least one nucleic acid is not bound but coated on a surface of the scaffold. Methods for regenerating bone using these gene-activated materials are also provided.

公开(公告)号：US11850328B2

公开(公告)日：2023-12-26

申请号：US16349186

申请日：2017-11-14

申请人： Northwestern University

发明人： Guillermo A. Ameer

IPC分类号： A61L27/46 ,  A61K9/00 ,  A61K9/08 ,  A61K47/32 ,  A61L27/18 ,  A61L27/50 ,  C08G63/47 ,  C08G63/91 ,  C08L67/00 ,  C08L101/00 ,  A61L27/16 ,  C08L101/16

CPC分类号： A61L27/46 ,  A61K9/00 ,  A61K9/0024 ,  A61K47/32 ,  A61L27/16 ,  A61L27/18 ,  A61L27/50 ,  C08G63/47 ,  C08G63/914 ,  C08L67/00 ,  C08L101/00 ,  C08L101/16 ,  A61L2300/802 ,  A61L2430/02 ,  A61L27/18 ,  C08L67/00 ,  A61L27/46 ,  C08L67/00

摘要： Provided herein are thermoresponsive polymer materials and methods of preparation and use thereof. In particular, materials are provided that cure upon exposure to physiologic conditions (e.g., human body temperature) and find use in, for example, orthopedic surgery, bone tissue engineering, and the repair of bone injuries and defects.

公开(公告)号：US11826949B2

公开(公告)日：2023-11-28

申请号：US16328448

申请日：2017-11-14

申请人： Desktop Metal, Inc.

发明人： Michael Andrew Gibson ,  Jonah Samuel Myerberg ,  Ricardo Fulop ,  Michael J. Tarkanian ,  Yet-Ming Chiang ,  Jay Tobia ,  Olivia Molnar Lam

IPC分类号： B29C64/124 ,  B29C64/245 ,  B29C64/165 ,  B33Y70/10 ,  C04B35/486 ,  C04B35/626 ,  C04B35/632 ,  C04B35/638 ,  G03F7/00 ,  G03F7/004 ,  A61K6/807 ,  A61K6/818 ,  A61K6/822 ,  A61K6/833 ,  C04B35/01 ,  C04B35/634 ,  B22F1/10 ,  B22F10/12 ,  B22F10/50 ,  A61L27/46 ,  B33Y50/02 ,  B29C64/135 ,  B22F7/04 ,  B28B1/00 ,  B33Y10/00 ,  B22F3/26 ,  B22F7/08 ,  B33Y80/00 ,  B82Y30/00 ,  B82Y40/00 ,  C22C9/06 ,  C22C19/03 ,  B22F12/90 ,  B22F10/64 ,  B22F1/102 ,  G03F7/027 ,  B22F3/10 ,  B29K509/02

CPC分类号： B29C64/124 ,  A61K6/807 ,  A61K6/818 ,  A61K6/822 ,  A61K6/833 ,  A61L27/46 ,  B22F1/10 ,  B22F3/26 ,  B22F7/04 ,  B22F7/08 ,  B22F10/12 ,  B22F10/50 ,  B28B1/001 ,  B29C64/135 ,  B29C64/165 ,  B29C64/245 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y70/10 ,  C04B35/013 ,  C04B35/486 ,  C04B35/6263 ,  C04B35/6264 ,  C04B35/632 ,  C04B35/634 ,  C04B35/638 ,  C04B35/63488 ,  G03F7/0037 ,  G03F7/0047 ,  G03F7/70416 ,  B22F1/102 ,  B22F3/1021 ,  B22F10/64 ,  B22F12/90 ,  B22F2007/042 ,  B22F2998/10 ,  B29K2509/02 ,  B33Y80/00 ,  B82Y30/00 ,  B82Y40/00 ,  C22C9/06 ,  C22C19/03 ,  G03F7/027 ,  B22F2998/10 ,  B22F10/12 ,  B22F3/1021 ,  B22F3/02

摘要： Systems, methods, components, and materials are disclosed for stereolithographic fabrication of three-dimensional, dense objects. A resin including at least one component of a binder system and dispersed particles can be exposed to an activation light source. The activation light source can cure the at least one component of the binder system to form a green object, which can include the at least one component of the binder system and the particles. A dense object can be formed from the green object by removing the at least one component of the binder system in an extraction process and thermally processing particles to coalesce into the dense object.

公开(公告)号：US20230372585A1

公开(公告)日：2023-11-23

申请号：US17632064

申请日：2020-08-07

申请人： The Fourth Military Medical University of Chinese People's Liberation Army

发明人： Lina NIU ,  Jihua CHEN ,  Kia JIAO ,  Minjuan SHEN ,  Yuxuan MA ,  Jianfei YAN ,  Qianqian WAN ,  Jing LI

IPC分类号： A61L27/24 ,  A61L27/12 ,  A61L27/46 ,  A61L27/54 ,  C12N15/87

CPC分类号： A61L27/24 ,  A61L27/12 ,  A61L27/46 ,  A61L27/54 ,  C12N15/87 ,  A61L2300/258 ,  A61L2300/412 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/12

摘要： Disclosed are nucleic acid-calcium phosphate nanoparticle complexes and application thereof in biomineralization. Specifically, disclosed are a biological mineralizer and a preparation method thereof. The mineralizer contains a complex formed by nucleic acid and amorphous calcium phosphate nanoparticles. Further, disclosed is a collagen fiber product containing the biological mineralizer or treated with the biological mineralizer, such as a medical device for being implanted into a patient. Further, disclosed is use of the biological mineralizer or the collagen fiber product in treatment of bone-associated diseases or disorders or improvement of bone conditions of patients. Further, disclosed is a method of using the biological mineralizer to induce biomimetic mineralization of collagen fibers or a preparation method of a mineralized collagen fiber product.

公开(公告)号：US11786638B2

公开(公告)日：2023-10-17

申请号：US17656642

申请日：2022-03-26

申请人： SHENZHEN CORLIBER SCIENTIFIC CO., LTD.

发明人： Yang Sun ,  Feng Pan ,  Yucheng Huang ,  Dong Xiang

IPC分类号： A61L27/46 ,  A61L27/48 ,  A61L27/58

CPC分类号： A61L27/46 ,  A61L27/48 ,  A61L27/58

摘要： The present invention relates to an absorbable biomedical composite material and a preparation method therefor, wherein the absorbable biomedical composite material comprises: a substrate particle containing a calcium phosphate compound; an intermediate layer which is coated on the surfaces of the substrate particle and has a first glass transition temperature, the first glass transition temperature being not higher than a normal body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The present invention can provide an absorbable biomedical composite material which not only increases the mechanical strength but also improves the toughness.