公开(公告)号：US20240308951A1

公开(公告)日：2024-09-19

申请号：US18379142

申请日：2023-10-11

申请人： Acucela Inc.

发明人： Claes Olof BAVIK ,  Susan Hayes HENRY ,  Ryo KUBOTA ,  Vladimir A. KUKSA

IPC分类号： C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

CPC分类号： C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

摘要： Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US20240173307A1

公开(公告)日：2024-05-30

申请号：US18330171

申请日：2023-06-06

申请人： Calico Life Sciences LLC ,  AbbVie Inc.

发明人： Kathleen Ann Martin ,  Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  Lei Shi ,  Qingwei Zhang ,  Zhaoming Xiong ,  Ramzi Farah Sweis ,  Michael J. Dart ,  Kathleen J. Murauski

IPC分类号： A61K31/44 ,  A61K31/165 ,  A61K31/18 ,  A61K31/341 ,  A61K31/35 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K45/06 ,  A61P25/28 ,  C07C237/24 ,  C07C311/46 ,  C07C323/40 ,  C07D213/40 ,  C07D213/64 ,  C07D213/71 ,  C07D213/75 ,  C07D213/85 ,  C07D231/12 ,  C07D233/64 ,  C07D235/14 ,  C07D237/14 ,  C07D239/34 ,  C07D239/47 ,  C07D241/12 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08

CPC分类号： A61K31/44 ,  A61K31/165 ,  A61K31/18 ,  A61K31/341 ,  A61K31/35 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K45/06 ,  A61P25/28 ,  C07C237/24 ,  C07C311/46 ,  C07C323/40 ,  C07D213/40 ,  C07D213/64 ,  C07D213/71 ,  C07D213/75 ,  C07D213/85 ,  C07D231/12 ,  C07D233/64 ,  C07D235/14 ,  C07D237/14 ,  C07D239/34 ,  C07D239/47 ,  C07D241/12 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08

摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US11786575B2

公开(公告)日：2023-10-17

申请号：US17696955

申请日：2022-03-17

申请人： Zoetis Services LLC

发明人： Michael P. Curtis ,  Susan M. Sheehan ,  Graham M. Kyne ,  Matthew W. Bedore ,  Richard A. Ewin ,  Paul D. Johnson ,  Tom L. McTier ,  Christopher S Knauer ,  Rajendran Vairagoundar

IPC分类号： A61K38/15 ,  A61P33/00 ,  C07K11/02 ,  A61K31/35 ,  A61K31/4188 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/7048 ,  A61K38/00

CPC分类号： A61K38/15 ,  A61K31/35 ,  A61K31/4188 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/7048 ,  A61P33/00 ,  C07K11/02 ,  A61K38/00

摘要： The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof




wherein each of R1, R2, R3, R4, L1, and L2, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.

公开(公告)号：US11707437B2

公开(公告)日：2023-07-25

申请号：US16925551

申请日：2020-07-10

申请人： Board of Trustees of Southern Illinois University ,  University of Wyoming

发明人： Louis Premkumar ,  Baskaran Thyagarajan

IPC分类号： A61K9/51 ,  A61K31/35 ,  A61K9/00 ,  A61K9/06 ,  A61K47/36 ,  A61K47/10 ,  A61K47/22 ,  A61P25/02 ,  A61K9/70 ,  A61K47/44

CPC分类号： A61K9/5153 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/7015 ,  A61K31/35 ,  A61K47/10 ,  A61K47/22 ,  A61K47/36 ,  A61K47/44 ,  A61P25/02

摘要： Nanoparticles comprising resiniferatoxin (RTX) encapsulated in a poly(lactic-co-glycolic acid) (PLGA) polymer and compositions, especially topical compositions, comprising the nanoparticles. The compositions can be used as topical formulations for ameliorating pain, including for diabetic patients with peripheral neuropathy.

公开(公告)号：US20230140631A1

公开(公告)日：2023-05-04

申请号：US18086830

申请日：2022-12-22

申请人： Boehringer Ingelheim Vetmedica GmbH

发明人： Dania Birte REICHE ,  Silke HAAG-DIERGARTEN ,  Leah Jeanette HENNINGS ,  Saskia KLEY ,  Anne M. TRAAS

IPC分类号： A61K31/351 ,  A61K38/28 ,  A61K31/7034 ,  C07D309/10 ,  C07H7/04 ,  A61P3/10 ,  A61K31/7042 ,  C07D493/10 ,  C07D493/08 ,  A61P3/06 ,  A61P31/12 ,  A61K31/357 ,  A61P9/12 ,  A61K31/381 ,  A61K31/7056 ,  C07H17/02 ,  C07D335/02 ,  A61K31/35 ,  A61K47/22 ,  C07D333/12 ,  A61P5/50 ,  A61P3/04 ,  C07H17/00 ,  C07H5/10 ,  A61P3/00 ,  C07H15/203 ,  A61P29/00 ,  C07D333/56

摘要： One or more SGLT2 inhibitors or pharmaceutically acceptable forms thereof are provided for use in the treatment and/or prevention of a metabolic disorder in a feline animal, preferably where the metabolic disorder is one or more selected from the group consisting of ketoacidosis, pre-diabetes, diabetes mellitus type 1 or type 2, insulin resistance, obesity, hyperglycemia, impaired glucose tolerance, hyperinsulinemia, dyslipidemia, dysadipokinemia, subclinical inflammation, systemic inflammation, low grade systemic inflammation, hepatic lipidosis, atherosclerosis, inflammation of the pancreas, neuropathy and/or Syndrome X (metabolic syndrome) and/or loss of pancreatic beta cell function and/or where the remission of the metabolic disorder, preferably diabetic remission, is achieved and/or maintained.

公开(公告)号：USRE49434E1

公开(公告)日：2023-02-28

申请号：US17219170

申请日：2021-03-31

申请人： Canopy Growth Corporation

发明人： Adam Mueller

IPC分类号： A61K36/00 ,  C07D311/80 ,  A61K31/35 ,  A61K36/185

摘要： The invention relates to a method for producing an extract from cannabis plant matter, containing tetrahydrocannabinol, cannabidiol and optionally the carboxylic acids thereof. According to said method, the dried plant matter is ground and subjected to a CO2 extraction and the primary extract obtained is separated. The invention method permits Δ8 or Δ9 tetrahydrocannabinol to be selectively obtained both from industrial hemp and from drug-producing hemp, optionally after dissolving the primary extract in ethanol, separating undesirable waxes and removing the solvent under reduced pressure.

公开(公告)号：US20220387468A1

公开(公告)日：2022-12-08

申请号：US17771159

申请日：2020-10-23

申请人： ASTRAZENECA AB

发明人： Elisabetta LEO ,  Claudia WINKLER ,  Mark James O'CONNOR ,  Gemma Nicole JONES ,  Andrew James PIERCE

IPC分类号： A61K31/7068 ,  A61K47/68 ,  A61K31/519 ,  A61P35/00 ,  A61K33/243 ,  A61K31/17 ,  A61K31/35 ,  A61P15/00 ,  G01N33/574

摘要： Methods of treating cancer with a combination of a WEE1 inhibitor and a DNA-damaging agent in patients having SLFN11-deficient cancer cells are disclosed herein.

公开(公告)号：US20220387388A1

公开(公告)日：2022-12-08

申请号：US17776021

申请日：2020-11-12

申请人： GSK CONSUMER HEAKTGCARE SARL

发明人： Matina PAPAFRAGHA

IPC分类号： A61K31/4164 ,  A61P17/16 ,  A61P11/02 ,  A61K9/00 ,  A61K31/045 ,  A61K31/23 ,  A61K31/35 ,  A61K31/569 ,  A61K36/185 ,  A61K36/22 ,  A61K36/47 ,  A61K36/54 ,  A61K36/758 ,  A61K36/899

摘要： There is provided a skin-care balm comprising 15% to 45% (w/w) of two or more waxes, wherein a first wax has a melting point of 70° C. to 90° C. and a second wax has a melting point of 30° C. to 60° C., the balm further comprising 45% to 70% (w/w) of an emollient and a skin soothing agent. The skin-care balm can be applied to the skin in the perinasal area. There is also provided a combination product comprising a skin-care balm and a nasal spray product.

公开(公告)号：US11491105B2

公开(公告)日：2022-11-08

申请号：US14766233

申请日：2014-02-10

申请人： Luoda Pharma Pty Ltd ,  Stephen Page ,  Sanjay Garg

发明人： Stephen Page ,  Sanjay Garg

IPC分类号： A61K9/00 ,  A61K31/35 ,  A61K31/352 ,  A61K45/06

摘要： The invention includes methods and compositions for treating mastitis in a subject. The method includes the step of administering, by intramammary delivery, a therapeutically effective amount of a polyether ionophore, or a therapeutically acceptable salt thereof, to the mammary gland of the subject.

公开(公告)号：US20220151957A1

公开(公告)日：2022-05-19

申请号：US17375807

申请日：2021-07-14

申请人： Anji Pharma (US) LLC

发明人： Alain D. Baron ,  Mark S. Fineman ,  Nigel R.A. Beeley

IPC分类号： A61K31/155 ,  A61K9/20 ,  A61K9/48 ,  A61K9/28 ,  A61K45/06 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/53 ,  A61K31/4196 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/55 ,  A61P3/10 ,  A61P3/08 ,  A61K31/137 ,  A61K31/35 ,  A61K31/485

摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.