公开(公告)号：US10668031B2

公开(公告)日：2020-06-02

申请号：US16037963

申请日：2018-07-17

Applicant: Anji Pharma (US) LLC

Inventor： Alain D. Baron ,  Mark S. Fineman ,  Nigel R. Beeley

IPC: A61K31/155 ,  A61K31/53 ,  A61K45/06 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61P3/10 ,  A61K9/00 ,  A61K9/16 ,  A61K31/137 ,  A61K31/341 ,  A61K31/343 ,  A61K31/357 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4196 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/485 ,  A61K31/55 ,  C07C279/26 ,  C07D207/06 ,  C07D207/34 ,  C07D211/14 ,  C07D249/14 ,  C07D251/10 ,  C07D251/18 ,  C07D255/02 ,  C07D307/52 ,  C07D307/66 ,  C07D317/58 ,  C07D401/04 ,  C07D405/12 ,  C07D409/12

Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

公开(公告)号：US10603291B2

公开(公告)日：2020-03-31

申请号：US15712026

申请日：2017-09-21

Applicant: Anji Pharma (US) LLC

Inventor： Alain D. Baron ,  Mark S. Fineman ,  Nigel R. A. Beeley

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/155 ,  A61K45/06 ,  C07C279/26 ,  A61K31/4196 ,  A61K31/53 ,  A61K31/55 ,  C07D317/58 ,  C07D405/12 ,  C07D249/14 ,  C07D251/10 ,  C07D251/18 ,  C07D255/02 ,  C07D307/52 ,  A61K31/36 ,  A61K9/00

Abstract: Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.

公开(公告)号：US20220151957A1

公开(公告)日：2022-05-19

申请号：US17375807

申请日：2021-07-14

Applicant: Anji Pharma (US) LLC

Inventor： Alain D. Baron ,  Mark S. Fineman ,  Nigel R.A. Beeley

IPC: A61K31/155 ,  A61K9/20 ,  A61K9/48 ,  A61K9/28 ,  A61K45/06 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/53 ,  A61K31/4196 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/55 ,  A61P3/10 ,  A61P3/08 ,  A61K31/137 ,  A61K31/35 ,  A61K31/485

Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

公开(公告)号：US11065215B2

公开(公告)日：2021-07-20

申请号：US16223002

申请日：2018-12-17

Applicant: Anji Pharma (US) LLC

Inventor： Alain D. Baron ,  Mark S. Fineman ,  Nigel R. A. Beeley

IPC: A61K31/155 ,  A61P3/10 ,  A61K9/20 ,  A61K9/48 ,  A61K9/28 ,  A61K45/06 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/53 ,  A61K31/4196 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/55 ,  A61K31/137 ,  A61K31/35 ,  A61K31/485

Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.