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公开(公告)号：US20210169892A1
公开(公告)日：2021-06-10
申请号：US16761354
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei I. Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph
IPC分类号： A61K31/538 , A61K45/06 , C07D317/46 , C07D209/08 , C07D413/06 , C07D265/36 , C07D217/16 , C07D311/66 , C07D413/12 , C07D319/20 , C07D307/85 , C07D209/42 , C07D493/04 , C07D405/12 , C07C235/22 , A61K31/36 , A61K31/4045 , A61K31/472 , A61K31/353 , A61K31/357 , A61K31/343 , A61K31/404
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20240018133A1
公开(公告)日：2024-01-18
申请号：US18462918
申请日：2023-09-07
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC分类号： C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08
CPC分类号： C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08 , A61K45/06
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20200345727A1
公开(公告)日：2020-11-05
申请号：US16761390
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K45/06 , C07D261/18 , C07D263/34 , C07D241/20 , A61K31/421 , A61K31/42 , A61K31/437 , C07D471/04 , C07D487/04 , C07D333/38 , C07D307/68 , A61K31/381 , A61K31/519 , A61K31/341 , A61K31/415 , A61K31/426 , A61K31/425 , C07D275/03 , C07D277/56 , C07D231/14 , C07D495/04 , A61K31/4985 , C07D237/20 , C07D413/04 , C07D285/06 , C07D317/46 , A61K31/36 , A61K31/4245 , A61K31/422 , A61K31/4196 , C07D249/10 , C07D217/26 , A61K31/472 , A61K31/196 , C07C233/62 , C07D401/04 , A61K31/4427 , A61K31/5355
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210393599A1
公开(公告)日：2021-12-23
申请号：US16761388
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Kathleen J. Murauski
IPC分类号： A61K31/44 , A61K45/06 , C07C237/24 , C07D213/40 , C07D241/12 , C07D261/08 , C07D277/28 , C07D213/64 , C07D263/32 , C07D231/12 , C07D213/71 , C07D307/52 , C07C323/40 , C07D213/85 , C07D213/75 , C07D271/06 , C07D405/12 , C07D401/12 , C07D239/47 , C07D233/64 , C07D333/20 , C07D471/04 , C07D237/14 , C07C311/46 , C07D235/14 , C07D239/34 , C07D471/08 , C07D493/08 , A61K31/165 , A61K31/4402 , A61K31/4965 , A61K31/426 , A61K31/42 , A61K31/4409 , A61K31/421 , A61K31/415 , A61K31/4406 , A61K31/341 , A61K31/4245 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/437 , A61K31/381 , A61K31/4045 , A61K31/4184 , A61K31/50 , A61K31/18 , A61K31/439 , A61K31/35 , A61P25/28
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20200347033A1
公开(公告)日：2020-11-05
申请号：US16761394
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , SeungWon Chung , Zhaoming Xiong , Kathleen J. Murauski , Qingwei I. Zhang , Brian S. Brown , Michael J. Dart
IPC分类号： C07D403/12 , C07D207/273 , C07D401/04 , C07D401/12 , C07D239/88 , C07D413/12 , C07D263/22 , C07D265/10 , C07D209/48 , C07D405/14 , C07D405/10 , C07D209/46
摘要： Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20240173307A1
公开(公告)日：2024-05-30
申请号：US18330171
申请日：2023-06-06
发明人： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Qingwei Zhang , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Kathleen J. Murauski
IPC分类号： A61K31/44 , A61K31/165 , A61K31/18 , A61K31/341 , A61K31/35 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/444 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K45/06 , A61P25/28 , C07C237/24 , C07C311/46 , C07C323/40 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/85 , C07D231/12 , C07D233/64 , C07D235/14 , C07D237/14 , C07D239/34 , C07D239/47 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D307/52 , C07D333/20 , C07D401/12 , C07D405/12 , C07D471/04 , C07D471/08 , C07D493/08
CPC分类号： A61K31/44 , A61K31/165 , A61K31/18 , A61K31/341 , A61K31/35 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/444 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K45/06 , A61P25/28 , C07C237/24 , C07C311/46 , C07C323/40 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/85 , C07D231/12 , C07D233/64 , C07D235/14 , C07D237/14 , C07D239/34 , C07D239/47 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D307/52 , C07D333/20 , C07D401/12 , C07D405/12 , C07D471/04 , C07D471/08 , C07D493/08
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240000792A1
公开(公告)日：2024-01-04
申请号：US18463183
申请日：2023-09-07
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph
IPC分类号： A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
CPC分类号： A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20200347043A1
公开(公告)日：2020-11-05
申请号：US16863747
申请日：2020-04-30
发明人： Kathleen Ann Martin , Carmela Sidrauski , Lei Shi , Kathleen J. Murauski , Xiangdong Xu , Yunsong Tong , John T. Randolph , Michael J. Dart , Hanae Benelkebir , Steven Edeson , Kathryn Starbuck
IPC分类号： C07D413/12 , A61P25/28 , A61K45/06 , A61K31/422 , C07D405/12 , A61K31/4155 , A61K31/403 , C07D311/24 , A61K31/353 , C07D311/22 , A61K31/4433 , A61K31/4245 , C07C235/36 , A61K31/165 , C07D493/08 , A61K31/4025 , C07C235/40 , C07D405/06 , A61K31/397 , C07D407/12 , C07D271/10 , C07D471/04 , A61K31/437
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20240307382A1
公开(公告)日：2024-09-19
申请号：US18330185
申请日：2023-06-06
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240166652A1
公开(公告)日：2024-05-23
申请号：US18324901
申请日：2023-05-26
发明人： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Brian S. Brown , Kathleen J. Murauski
IPC分类号： C07D487/04 , C07C235/22 , C07D213/30 , C07D213/643 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/20 , C07D271/07 , C07D271/113
CPC分类号： C07D487/04 , C07C235/22 , C07D213/30 , C07D213/643 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/20 , C07D271/07 , C07D271/113
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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