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公开(公告)号：US20220363678A1
公开(公告)日：2022-11-17
申请号：US17103003
申请日：2020-11-24
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC分类号： C07D471/04 , C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C235/22 , C07C311/13 , C07D237/14 , C07C311/24 , C07C317/22 , C07D237/16 , A61P25/28
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US11149043B2
公开(公告)日：2021-10-19
申请号：US17227071
申请日：2021-04-09
发明人： Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC分类号： C07F9/12
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20210269399A1
公开(公告)日：2021-09-02
申请号：US17038179
申请日：2020-09-30
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC分类号： C07D213/42 , C07D231/12 , C07D237/08 , C07D239/34 , C07D241/12 , C07D471/04 , C07D261/08 , C07D263/32 , C07D277/28 , C07D209/14 , C07C235/22 , C07D213/40 , C07D213/64 , C07D307/52 , C07D271/07 , A61K31/18 , A61K31/197 , A61K31/341 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/417 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C311/16 , C07C323/09 , C07D213/89 , C07D235/00 , C07D271/10 , C07D307/36 , C07D333/20
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210169892A1
公开(公告)日：2021-06-10
申请号：US16761354
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei I. Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph
IPC分类号： A61K31/538 , A61K45/06 , C07D317/46 , C07D209/08 , C07D413/06 , C07D265/36 , C07D217/16 , C07D311/66 , C07D413/12 , C07D319/20 , C07D307/85 , C07D209/42 , C07D493/04 , C07D405/12 , C07C235/22 , A61K31/36 , A61K31/4045 , A61K31/472 , A61K31/353 , A61K31/357 , A61K31/343 , A61K31/404
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US10913727B2
公开(公告)日：2021-02-09
申请号：US16098679
申请日：2017-05-05
发明人： Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC分类号： C07D307/82 , C07D213/74 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07D277/32 , C07D213/57 , C07D307/56 , C07C233/74 , C07D213/54 , C07C235/54 , C07C233/79 , C07C255/41 , C07C255/57 , C07C235/14
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20190142806A1
公开(公告)日：2019-05-16
申请号：US16098950
申请日：2017-05-05
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240018133A1
公开(公告)日：2024-01-18
申请号：US18462918
申请日：2023-09-07
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC分类号： C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08
CPC分类号： C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08 , A61K45/06
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20210230195A1
公开(公告)日：2021-07-29
申请号：US17227071
申请日：2021-04-09
发明人： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC分类号： C07F9/12
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20200345727A1
公开(公告)日：2020-11-05
申请号：US16761390
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K45/06 , C07D261/18 , C07D263/34 , C07D241/20 , A61K31/421 , A61K31/42 , A61K31/437 , C07D471/04 , C07D487/04 , C07D333/38 , C07D307/68 , A61K31/381 , A61K31/519 , A61K31/341 , A61K31/415 , A61K31/426 , A61K31/425 , C07D275/03 , C07D277/56 , C07D231/14 , C07D495/04 , A61K31/4985 , C07D237/20 , C07D413/04 , C07D285/06 , C07D317/46 , A61K31/36 , A61K31/4245 , A61K31/422 , A61K31/4196 , C07D249/10 , C07D217/26 , A61K31/472 , A61K31/196 , C07C233/62 , C07D401/04 , A61K31/4427 , A61K31/5355
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240307382A1
公开(公告)日：2024-09-19
申请号：US18330185
申请日：2023-06-06
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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