公开(公告)号：US06548053B1

公开(公告)日：2003-04-15

申请号：US09591406

申请日：2000-06-12

申请人： Paul Michael Stewart ,  Philip Ian Murray

发明人： Paul Michael Stewart ,  Philip Ian Murray

IPC分类号： A61K908

CPC分类号： A61K31/57 ,  A61K9/0048 ,  A61K31/00 ,  A61K31/222 ,  A61K31/704

摘要： A method of reducing intra-ocular pressure (IOP) in a patient afflicted with elevated IOP is disclosed. The method comprises the step of administering (preferably topically to an afflicted eye) to the patient a therapeutically effective amount of a &bgr;-HSD-1 inhibitor.

摘要翻译： 公开了一种降低患有IOP升高的患者的眼内压（IOP）的方法。 该方法包括向患者施用治疗有效量的β-HSD-1抑制剂（优选局部地给患病眼睛）的步骤。

公开(公告)号：US06251437B1

公开(公告)日：2001-06-26

申请号：US09352325

申请日：1999-07-13

申请人： LeRoy J. Fischbach

发明人： LeRoy J. Fischbach

IPC分类号： A61K908

CPC分类号： A61M1/1654 ,  A61K9/08 ,  Y10S514/832

摘要： A hemodialysis acid concentrate which includes, before mixing, sodium chloride powder and sometimes dextrose powder as a powder component, and a liquid component which contains some or all of the following: potassium chloride, magnesium chloride, sodium chloride, dextrose, calcium chloride, and an acid from the group lactic acid, acetic acid, and citric acid. The liquid and powder components are added to a specified volume of water to make a final acid concentrate. The individual components are easily inspected for quality control and the shipping weight is greatly reduced compared to conventional liquid acid concentrates.

摘要翻译： 一种血液透析酸浓缩物，其在混合前包括氯化钠粉末和有时作为粉末成分的葡萄糖粉末，以及含有以下部分或全部的液体组分：氯化钾，氯化镁，氯化钠，葡萄糖，氯化钙和 来自乳酸，乙酸和柠檬酸的酸。 将液体和粉末成分加入到特定体积的水中以制成最终的酸浓缩物。 单个部件易于检查质量控制，与常规液体酸浓缩物相比，运输重量大大降低。

公开(公告)号：US06224893B1

公开(公告)日：2001-05-01

申请号：US08862740

申请日：1997-05-23

申请人： Robert S. Langer ,  Jennifer H. Elisseeff ,  Kristi Anseth ,  Derek Sims

发明人： Robert S. Langer ,  Jennifer H. Elisseeff ,  Kristi Anseth ,  Derek Sims

IPC分类号： A61K908

CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K47/32 ,  A61L27/26 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3852 ,  A61L27/50 ,  A61L27/52 ,  Y10S525/903 ,  Y10S525/937

摘要： Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs. As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous souce of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.

摘要翻译： 已经开发了用于组织工程和药物递送的组合物，其基于在需要其的患者的部位注射后暴露于活性物质时形成半互穿或互穿聚合物网络的两种或更多种聚合物的溶液。 聚合物自身交联而不是彼此交联; 当只有一种聚合物交联时，形成半互穿网络。 所得到的粘性溶液将生物活性分子或细胞保留在注射部位，直到发生释放或组织形成。作为通过聚合物 - 细胞悬浮液形成互穿聚合物网络进行的研究的结果，已经确定聚合物溶液可以 其中通过将聚合物溶液暴露于活性物质的外源性水，通常是电磁辐射，优选轻的提供活性物质。 研究表明，光将穿透皮肤，体液（如滑液）和膜，并聚合聚合物溶液。 聚合物溶液可以离子交换或共价交联，以形成水凝胶，半互穿聚合物网络或互穿聚合物网络。

公开(公告)号：US06696072B1

公开(公告)日：2004-02-24

申请号：US09494627

申请日：2000-01-31

申请人： Joseph S. Podolski

发明人： Joseph S. Podolski

IPC分类号： A61K908

CPC分类号： A61K31/557 ,  A61K31/415 ,  A61K31/5575 ,  A61K45/06 ,  A61K31/47 ,  A61K31/505 ,  A61K2300/00

摘要： Improved drug compositions and methods useful in the treatment of male erectile dysfunction. An optimized mixture of the drugs phentolamine mesylate, papaverine hydrochloride, and alprostadil in a buffer containing L-arginine and glycine is to be injected into the penile tissue to produce an erection in otherwise impotent men.

摘要翻译： 改善用于治疗男性勃起功能障碍的药物组合物和方法。 在含有L-精氨酸和甘氨酸的缓冲液中药物酚妥拉明甲磺酸盐，盐酸罂粟碱和前列地尔的优化混合物将被注射到阴茎组织中，以产生其他无能力男性的勃起。

公开(公告)号：US06572873B1

公开(公告)日：2003-06-03

申请号：US09718094

申请日：2000-11-22

申请人： Tariq Osman ,  Sheila Bronwen Flynn ,  David Dakin Iorwerth Wright ,  Anthony David Harman ,  Timothy David Boorman

发明人： Tariq Osman ,  Sheila Bronwen Flynn ,  David Dakin Iorwerth Wright ,  Anthony David Harman ,  Timothy David Boorman

IPC分类号： A61K908

CPC分类号： A61K9/122 ,  A61K9/0019 ,  A61K31/08 ,  B05B7/0037 ,  B05B11/02 ,  B65D83/14 ,  B65D83/20 ,  B65D83/48 ,  B65D83/60 ,  B65D83/62 ,  Y10S514/945

摘要： Improved therapeutic sclerosing microfoams and methods and devices for making them are provided that have advantage in producing a consistent profile injectable foam with minimal input by the physician yet using high volume percentages of blood dispersible gases, thus avoiding use of potentially hazardous amounts of nitrogen.

公开(公告)号：USRE37950E1

公开(公告)日：2002-12-31

申请号：US09536579

申请日：2000-03-28

申请人： Richard L. Dunn ,  James P. English ,  Donald R. Cowsar ,  David P. Vanderbilt

发明人： Richard L. Dunn ,  James P. English ,  Donald R. Cowsar ,  David P. Vanderbilt

IPC分类号： A61K908

CPC分类号： A61K9/0024 ,  A61F2002/30062 ,  A61F2002/30583 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61L15/44 ,  A61L15/62 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/009 ,  A61L27/18 ,  A61L27/50 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/406 ,  C08L75/04 ,  C08L67/04

摘要： A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

摘要翻译： 提供可生物降解的聚合物用于为动物提供可注射的，原位成型的固体可生物降解植入物。 将聚合物以液体形式置于动物体内并固化以原位形成植入物。 形成所述植入物的热塑性体系包括以下步骤：将非反应性聚合物溶解在生物相容性溶剂中以形成液体，将液体置于动物体内，并允许溶剂消散以产生植入物。 一种替代的热固性体系包括将有效量的液体丙烯酸酯封端的，可生物降解的预聚物和固化剂混合在一起，将液体混合物置于动物体内并使预聚物固化以形成植入物。 两种系统通过在注射到体内之前向液体中添加有效水平的生物活性剂来提供可注射的，可固体的可生物降解的递送系统。

公开(公告)号：US06322821B1

公开(公告)日：2001-11-27

申请号：US09405960

申请日：1999-09-27

申请人： Jack W. Register

发明人： Jack W. Register

IPC分类号： A61K908

CPC分类号： A61K33/14 ,  Y10S514/904 ,  Y10S514/905 ,  A61K31/714 ,  A61K31/525 ,  A61K31/51 ,  A61K31/44 ,  A61K31/195 ,  A61K2300/00

摘要： A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content is lower than conventional calcium treatments used for this purpose. The propylene glycol gives the cow an energy boost and sweetens the taste so the cow does not object to it as it does to conventional gels and liquids. The B vitamins stimulate the cow's appetite. The minerals replace minerals lost in the milk and also help the cow absorb calcium. The composition of the present invention is in a liquid form and is preferably administered using a 200-300 cc drench gun. The end of the dispensing tube of the drench gun is placed between the teeth and cheek of the cow near the receptors that stimulate the esophageal groove reflex. A feature near the end of the dispensing tube causes a bulge in the cow's cheek which indicates the position of the dispensing tube within the cow's mouth. The composition stimulates the receptors and closes the esophageal groove, thereby allowing the liquid into the omasum where calcium is absorbed quicker than in the rumen. The cow swallows the liquid mixture in a near normal manner which prevents the solution from causing aspiration pneumonia.

摘要翻译： 用于在清新奶牛中预防和治疗牛奶热的组合物和施用该组合物的方法。 基本组成是水，氯化钙，丙二醇，B族维生素和矿物质的混合物。 钙含量低于用于此目的的常规钙处理。 丙二醇给牛提供能量，并使味道变甜，因此母牛不会象传统的凝胶和液体那样反对它。 B族维生素刺激牛的胃口。 矿物质代替了牛奶中的矿物质，也帮助牛吸收钙。 本发明的组合物为液体形式，优选使用200-300cc的喷枪施用。 喷枪的分配管的末端被放置在刺激食管沟反射的受体附近的母牛和母牛的脸颊之间。 分配管末端附近的特征导致牛的脸颊中的凸起，其指示分配管在牛的嘴内的位置。 该组合物刺激受体并闭合食道槽，从而使液体进入钙，其中钙被吸收比瘤胃快。 牛以接近正常的方式吞咽液体混合物，防止溶液引起吸入性肺炎。

公开(公告)号：US06761903B2

公开(公告)日：2004-07-13

申请号：US09877541

申请日：2001-06-08

申请人： Feng-Jing Chen ,  Mahesh V. Patel ,  David T. Fikstad

发明人： Feng-Jing Chen ,  Mahesh V. Patel ,  David T. Fikstad

IPC分类号： A61K908

CPC分类号： B82Y5/00 ,  A61K9/4808 ,  A61K9/4858 ,  A61K9/4891 ,  Y10S514/937 ,  Y10S514/944

摘要： The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a carrier, where the carrier is formed from a combination of a triglyceride and at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous medium, the carrier forms a clear, aqueous dispersion of the triglyceride and surfactants.

摘要翻译： 本发明涉及药物组合物和改善甘油三酯溶解度和改善治疗剂递送的方法。 本发明的组合物包括载体，其中载体由甘油三酯和至少两种表面活性剂的组合形成，其中至少一种是亲水的。 用水介质稀释后，载体形成甘油三酯和表面活性剂的透明水性分散体。

公开(公告)号：US06660279B2

公开(公告)日：2003-12-09

申请号：US10347046

申请日：2003-01-17

申请人： Anna Lundgren ,  Mats Sundgren

发明人： Anna Lundgren ,  Mats Sundgren

IPC分类号： A61K908

CPC分类号： A61J1/05 ,  A61J1/062 ,  A61J1/1468 ,  A61K9/0019 ,  A61K31/724 ,  A61K47/40 ,  A61M5/3129

摘要： A primary package containing a low molecular weight peptide-based thrombin inhibitors which package is sealed with a rubber stopper or plunger containing bromobutyl rubber.

公开(公告)号：US06660278B1

公开(公告)日：2003-12-09

申请号：US09341294

申请日：1999-07-08

申请人： Kåre Larsson ,  Helena Ljusberg-Wahren ,  Niels Krog

发明人： Kåre Larsson ,  Helena Ljusberg-Wahren ,  Niels Krog

IPC分类号： A61K908

CPC分类号： A61K9/1274 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/941 ,  Y10S514/943

摘要： A controlled release composition for a biologically active material, which composition is liquid or liquid crystalline and comprises at least one medium or long-chain fatty acid ester of diglycerol as a carrier for said biologically active material, said biologically active material being dissolved or dispersed in said carrier. Said composition is especially useful as a medical composition.

摘要翻译： 用于生物活性物质的控释组合物，其组成为液体或液晶，并且包含至少一种作为所述生物活性物质的载体的二甘油的中长链脂肪酸酯，所述生物活性物质溶解或分散在 承运人 所述组合物特别可用作医药组合物。