公开(公告)号：US20240285677A1

公开(公告)日：2024-08-29

申请号：US18658338

申请日：2024-05-08

申请人： Hope Medical Enterprises, Inc. dba Hope Pharmaceuticals

发明人： Craig Sherman

IPC分类号： A61K33/00 ,  A61M1/16

CPC分类号： A61K33/00 ,  A61M1/1654

摘要： Provided herein are methods for maintaining physiological levels of nitrite in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium nitrite to a subject undergoing hemodialysis.

公开(公告)号：US20240269358A1

公开(公告)日：2024-08-15

申请号：US18583836

申请日：2024-02-21

申请人： DEKA Products Limited Partnership

发明人： Dirk A. van der Merwe ,  Kevin L. Grant ,  Michael J. Wilt ,  Todd A. Ballantyne ,  Jonathan P. Rosse ,  Catharine N. Flynn ,  Brian K. Yee

IPC分类号： A61M1/16 ,  A61K33/00 ,  A61M1/14 ,  A61M1/26 ,  A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  A61M5/172 ,  A61M60/113 ,  A61M60/268 ,  A61M60/37 ,  A61M60/427 ,  A61M60/43 ,  A61M60/837 ,  A61M60/847 ,  A61M60/851 ,  A61M60/892 ,  A61M60/894 ,  G16H20/40

CPC分类号： A61M1/1601 ,  A61K33/00 ,  A61M1/14 ,  A61M1/1524 ,  A61M1/154 ,  A61M1/155 ,  A61M1/156 ,  A61M1/15625 ,  A61M1/15632 ,  A61M1/1565 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/1654 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/166 ,  A61M1/1664 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1692 ,  A61M1/267 ,  A61M1/301 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3609 ,  A61M1/3621 ,  A61M1/362227 ,  A61M1/36224 ,  A61M1/36225 ,  A61M1/36226 ,  A61M1/362264 ,  A61M1/362265 ,  A61M1/362266 ,  A61M1/3627 ,  A61M1/3672 ,  A61M5/172 ,  A61M60/113 ,  A61M60/268 ,  A61M60/37 ,  A61M60/427 ,  A61M60/43 ,  A61M60/837 ,  A61M60/847 ,  A61M60/851 ,  G16H20/40 ,  A61M1/1561 ,  A61M1/362261 ,  A61M1/3638 ,  A61M60/892 ,  A61M60/894 ,  A61M2205/12 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65 ,  Y02A50/30 ,  Y02A90/10

摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

公开(公告)号：US20240100086A1

公开(公告)日：2024-03-28

申请号：US18239405

申请日：2023-08-29

申请人： Hope Medical Enterprises, Inc. dba Hope Pharmaceuticals

发明人： Craig Sherman

IPC分类号： A61K33/04 ,  A61M1/16

CPC分类号： A61K33/04 ,  A61M1/1654 ,  A61M1/1656

摘要： Provided herein are methods for maintaining physiological levels of thiosulfate in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium thiosulfate to a subject undergoing hemodialysis.

公开(公告)号：US20240016989A1

公开(公告)日：2024-01-18

申请号：US18035048

申请日：2021-10-29

申请人： GAMBRO LUNDIA AB

发明人： Dominique Pouchoulin

IPC分类号： A61M1/16 ,  A61M1/36 ,  A61M60/113 ,  A61M60/279 ,  A61M1/34 ,  G16H20/40 ,  G16H20/17

CPC分类号： A61M1/1603 ,  A61M1/3672 ,  A61M60/113 ,  A61M60/279 ,  A61M1/1654 ,  A61M1/3403 ,  G16H20/40 ,  G16H20/17 ,  A61M2205/3334

摘要： A CRRT apparatus comprising a control unit configured to execute a flow-rate setup procedure by receiving a patient prescription comprising clinical prescription parameters, by allowing entry of a set value for a prescribed dialysis dose (Dset) to be delivered, and of a target value for a parameter (nNBL; CpHCO3_pat) indicative of a steady state acid-base balance in the blood of the patient who has to undergo a CRRT blood treatment, and by determining operating parameters calculating a set value of relevant fluid flow rates including one or more of a fluid flow rate (Qcit) through the anticoagulant infusion line, a fluid flow rate (QPBP) through the PBP infusion line, a fluid flow rate (Qrep_pre) through the pre-dilution infusion line, a fluid flow rate (Qrep_post) through the post-dilution infusion line, a fluid flow rate (QHCO3) through the post-dilution bicarbonate infusion line, a fluid flow rate (Qca) through the ion balancing infusion line, a blood fluid flow rate (Qb) through the extracorporeal blood circuit, a fluid flow rate (Qdial) through the dialysis liquid supply line, and a fluid flow rate (Qeff) through the effluent fluid line, wherein calculating the set value of the fluid flow rates is based at least on the set value of the prescribed dialysis dose (Dset) and on the target value for the parameter (nNBL; CpHCO3_pat) indicative of a steady state acid-base balance in the blood.

公开(公告)号：US11793915B2

公开(公告)日：2023-10-24

申请号：US17493758

申请日：2021-10-04

申请人： DEKA Products Limited Partnership

发明人： Michael J. Wilt ,  Jason A. Demers ,  Kevin L. Grant ,  Brian D. Tracey ,  James D. Dale

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61M1/26 ,  A61M1/14

CPC分类号： A61M1/1601 ,  A61M1/154 ,  A61M1/155 ,  A61M1/1561 ,  A61M1/1565 ,  A61M1/15625 ,  A61M1/16 ,  A61M1/1621 ,  A61M1/1654 ,  A61M1/1694 ,  A61M1/267 ,  A61M1/3401 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3424 ,  A61M1/365 ,  A61M1/3609 ,  A61M1/3621 ,  A61M1/3638 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3649 ,  A61M1/3652 ,  A61M1/3672 ,  A61M1/36224 ,  A61M1/362261 ,  A61M1/362263 ,  A61M1/362265 ,  A61M1/362266 ,  A61M2205/07 ,  A61M2205/12 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/15 ,  A61M2205/16 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/36 ,  A61M2205/505 ,  A61M2205/82 ,  A61M2205/8218 ,  A61M2205/8225 ,  Y10T137/87893

摘要： The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.

公开(公告)号：US11779689B2

公开(公告)日：2023-10-10

申请号：US17393268

申请日：2021-08-03

申请人： DEKA Products Limited Partnership

发明人： Dirk A. van der Merwe ,  Kevin L. Grant ,  Michael J. Wilt

IPC分类号： A61M1/16 ,  A61M5/172 ,  A61M1/14 ,  A61M1/34 ,  A61M1/36 ,  G16H20/40 ,  A61M60/268 ,  A61M1/26 ,  A61M1/30 ,  A61K33/00 ,  A61M60/43 ,  A61M60/113 ,  A61M60/851 ,  A61M60/427 ,  A61M60/847 ,  A61M60/837 ,  A61M60/37 ,  A61M60/892 ,  A61M60/894

CPC分类号： A61M1/1601 ,  A61K33/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/166 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/1654 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/1664 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1692 ,  A61M1/267 ,  A61M1/301 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3609 ,  A61M1/3621 ,  A61M1/3627 ,  A61M1/3672 ,  A61M5/172 ,  A61M60/113 ,  A61M60/268 ,  A61M60/37 ,  A61M60/427 ,  A61M60/43 ,  A61M60/837 ,  A61M60/847 ,  A61M60/851 ,  G16H20/40 ,  A61M1/3638 ,  A61M60/892 ,  A61M60/894 ,  A61M2205/12 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65 ,  Y02A50/30 ,  Y02A90/10

摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

公开(公告)号：US20230149612A1

公开(公告)日：2023-05-18

申请号：US17977785

申请日：2022-10-31

申请人： Fresenius Medical Care Holdings, Inc.

发明人： David Yuds ,  Eric Bergman ,  Jonathan Leclerc ,  Jessica Steuber ,  Areeba Zakir ,  Laura Chang ,  Diego Suarez del Real Pena

IPC分类号： A61M1/28 ,  A61M1/16

CPC分类号： A61M1/28 ,  A61M1/1654 ,  A61M2205/12

摘要： The present teachings may generally include a first fluid connector that includes a first body having a first central cavity that defines a first fluid pathway and a first seal within the first central cavity. The first seal includes a pair of first interfacing elements positioned adjacent one another at a distal end of the first seal and a first opening configured to remain sealed closed when the first interfacing elements are adjacent, and the first opening opens when the first interfacing elements are separated. The first connector is configured to fluidly connect to a second connector by engaging the first interfacing elements and with a pair of second interfacing elements of the second connector, thereby causing both pairs of first and second interfacing elements to separate causing the opening of first opening and second opening.

公开(公告)号：US20190184084A1

公开(公告)日：2019-06-20

申请号：US16219964

申请日：2018-12-14

申请人： LITE-ON ELECTRONICS (GUANGZHOU) LIMITED ,  Lite-On Technology Corporation

发明人： Wei-Ming Shieh ,  Yi-Feng Pu ,  Pei-Hsuan Huang

IPC分类号： A61M1/16

CPC分类号： A61M1/1623 ,  A61M1/1601 ,  A61M1/1652 ,  A61M1/1654

摘要： A dialyzer and a fabricating method thereof are provided. The dialyzer includes a housing, a hydrophilic layer, a fixing layer, a plurality of hollow fiber membranes, and two end caps. The housing has a first opening and a second opening, and is provided with a dialysate inlet and a dialysate outlet, wherein an entire peripheral surface of the housing located between the first opening and the dialysate inlet is a first portion, and an entire peripheral surface of the housing located between the second opening and the dialysate outlet is a second portion. The hydrophilic layer is disposed on the inner wall of the first portion and the second portion, wherein the hydrophilic layer and the housing are different materials. The fixing layer is disposed on the hydrophilic layer and fixes the hollow fiber membranes to the inner wall of the housing.

公开(公告)号：US10016550B2

公开(公告)日：2018-07-10

申请号：US14680846

申请日：2015-04-07

申请人： EASYDIAL INC.

发明人： Renato Giordano ,  Rodney Corder

IPC分类号： A61M1/16 ,  A61M1/36 ,  A61M1/26

CPC分类号： A61M1/1605 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1609 ,  A61M1/1621 ,  A61M1/1645 ,  A61M1/1654 ,  A61M1/1658 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/3626 ,  A61M1/3661 ,  A61M2205/125 ,  A61M2205/126 ,  A61M2205/127 ,  A61M2205/15 ,  A61M2205/27 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/3327 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3653 ,  A61M2205/50 ,  A61M2205/75

摘要： A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate, and pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. Preferably, the filter has a vapor membrane for releasing gases including ammonia, but not liquids such as the dialysate. The reused dialysis machine possesses a reservoir for dialysate, an ammonia sensor adjacent to the vapor membrane, a level sensor, a blood leak sensor, a venous blood line pressure sensor, a venous blood line bubble detector, pump motors, and a processor connected to the motors and sensors for controlling and monitoring hemodialysis treatment.

公开(公告)号：US20180071335A1

公开(公告)日：2018-03-15

申请号：US15703578

申请日：2017-09-13

申请人： SECURERF CORPORATION

发明人： IRIS ANSHEL ,  MICHAEL ANSHEL ,  DORIAN GOLDFELD

IPC分类号： A61K33/14 ,  A61K31/194 ,  A61M1/14 ,  A61K9/08 ,  A61M1/16 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/06

CPC分类号： A61K33/14 ,  A61K9/08 ,  A61K31/194 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/06 ,  A61M1/14 ,  A61M1/1654 ,  H04L9/0841 ,  H04L9/0861 ,  H04L9/0869 ,  H04L9/14 ,  H04L9/30 ,  H04L9/3013 ,  H04L63/0428 ,  H04L2209/12

摘要： A system and method for generating a secret key to facilitate secure communications between users. A first and second and a function between the two monoids are selected, the function being a monoid homomorphism. A group and a group action of the group on the first monoid is selected. Each user is assigned a submonoid of the first monoid so that these submonoids satisfy a special symmetry property determined by the function, a structure of the first and second monoids, and the action of the group. A multiplication of an element in the second monoid and an element in the first monoid is obtained by combining the group action and the monoid homomorphism. First and second users choose private keys which are sequences of elements in their respective submonoids. A first result is obtained by multiplying an identity element by the first element of the sequence in a respective submonoid. Starting with the first result, each element of the user's private key may be iteratively multiplied by the previous result to produce a public key. Public keys are exchanged between first and second users. Each user's private key may be iteratively multiplied by the other user's public key to produce a secret key. Secure communication may then occur between the first and second user using the secret key.