公开(公告)号：US11872333B1

公开(公告)日：2024-01-16

申请号：US17814549

申请日：2022-07-25

申请人： William M. Gosney ,  Dale B. Nixon

发明人： William M. Gosney ,  Dale B. Nixon

IPC分类号： A61M1/36 ,  A61M60/36 ,  A61M60/279 ,  A61M60/113 ,  A61M1/14

CPC分类号： A61M1/1562 ,  A61M1/3672 ,  A61M1/36226 ,  A61M60/113 ,  A61M60/279 ,  A61M60/36

摘要： An apparatus for locating and venting pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, a pump is operated to move the identified cells to a processing zone. When each identified cell reaches the processing zone, a control voltage is generated to open a valve to vent the identified pathogen cells. The pump refills the cassette holding chambers, returns the processed blood to the patient, and the procedure is repeated for a treatment time period.

公开(公告)号：US20230381383A1

公开(公告)日：2023-11-30

申请号：US18446323

申请日：2023-08-08

申请人： DEKA Products Limited Partnership

发明人： Dirk A. van der Merwe ,  Kevin L. Grant ,  Michael J. Wilt

IPC分类号： A61M1/16 ,  A61M1/36 ,  A61K33/00 ,  A61M60/427 ,  A61M60/37 ,  A61M1/30 ,  A61M5/172 ,  A61M1/34 ,  G16H20/40 ,  A61M1/14 ,  A61M60/43 ,  A61M1/26 ,  A61M60/837 ,  A61M60/268 ,  A61M60/113 ,  A61M60/851 ,  A61M60/847 ,  A61M60/894 ,  A61M60/892

CPC分类号： A61M1/1601 ,  A61M1/1654 ,  A61M1/166 ,  A61M1/3609 ,  A61K33/00 ,  A61M60/427 ,  A61M60/37 ,  A61M1/362266 ,  A61M1/362227 ,  A61M1/362265 ,  A61M1/301 ,  A61M5/172 ,  A61M1/1692 ,  A61M1/34 ,  A61M1/3627 ,  G16H20/40 ,  A61M1/1668 ,  A61M1/1666 ,  A61M1/3413 ,  A61M1/1524 ,  A61M1/156 ,  A61M1/1605 ,  A61M1/1619 ,  A61M1/341 ,  A61M60/43 ,  A61M1/15632 ,  A61M1/1565 ,  A61M1/36224 ,  A61M1/36225 ,  A61M1/362264 ,  A61M1/267 ,  A61M1/1613 ,  A61M60/837 ,  A61M1/15625 ,  A61M1/154 ,  A61M1/3621 ,  A61M1/1658 ,  A61M1/1664 ,  A61M60/268 ,  A61M60/113 ,  A61M1/3672 ,  A61M1/36226 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1656 ,  A61M60/851 ,  A61M60/847 ,  A61M1/155 ,  A61M2205/3317 ,  A61M2205/3334 ,  A61M2205/3584 ,  A61M1/362261 ,  A61M2205/3368 ,  A61M2205/3313 ,  A61M2205/3379 ,  A61M2205/3324 ,  A61M60/894 ,  Y02A90/10 ,  A61M2205/18 ,  A61M2205/50 ,  A61M60/892 ,  A61M2205/12 ,  A61M2205/3306 ,  Y02A50/30 ,  A61M2205/15 ,  A61M2205/3569 ,  A61M1/3638 ,  A61M2205/3331 ,  A61M2205/52 ,  A61M2205/502 ,  A61M1/1561 ,  A61M2230/65

摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

公开(公告)号：US11801336B1

公开(公告)日：2023-10-31

申请号：US17814542

申请日：2022-07-25

申请人： William M. Gosney ,  Dale B. Nixon

发明人： William M. Gosney ,  Dale B. Nixon

IPC分类号： A61M1/36 ,  A61L2/00 ,  A61M60/113 ,  A61M60/36 ,  A61M60/279

CPC分类号： A61M1/36226 ,  A61L2/0011 ,  A61M1/3672 ,  A61M60/113 ,  A61M60/279 ,  A61M60/36 ,  A61L2202/22

摘要： An operational unit for locating and neutralizing pathogen cells in blood includes a time use cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood selectively block the light to produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, an electric field is activated in the cassette chamber areas that include the identified pathogen cells. Sufficient electric field energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a period of time.

公开(公告)号：US20240269358A1

公开(公告)日：2024-08-15

申请号：US18583836

申请日：2024-02-21

申请人： DEKA Products Limited Partnership

发明人： Dirk A. van der Merwe ,  Kevin L. Grant ,  Michael J. Wilt ,  Todd A. Ballantyne ,  Jonathan P. Rosse ,  Catharine N. Flynn ,  Brian K. Yee

IPC分类号： A61M1/16 ,  A61K33/00 ,  A61M1/14 ,  A61M1/26 ,  A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  A61M5/172 ,  A61M60/113 ,  A61M60/268 ,  A61M60/37 ,  A61M60/427 ,  A61M60/43 ,  A61M60/837 ,  A61M60/847 ,  A61M60/851 ,  A61M60/892 ,  A61M60/894 ,  G16H20/40

CPC分类号： A61M1/1601 ,  A61K33/00 ,  A61M1/14 ,  A61M1/1524 ,  A61M1/154 ,  A61M1/155 ,  A61M1/156 ,  A61M1/15625 ,  A61M1/15632 ,  A61M1/1565 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/1654 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/166 ,  A61M1/1664 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1692 ,  A61M1/267 ,  A61M1/301 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3609 ,  A61M1/3621 ,  A61M1/362227 ,  A61M1/36224 ,  A61M1/36225 ,  A61M1/36226 ,  A61M1/362264 ,  A61M1/362265 ,  A61M1/362266 ,  A61M1/3627 ,  A61M1/3672 ,  A61M5/172 ,  A61M60/113 ,  A61M60/268 ,  A61M60/37 ,  A61M60/427 ,  A61M60/43 ,  A61M60/837 ,  A61M60/847 ,  A61M60/851 ,  G16H20/40 ,  A61M1/1561 ,  A61M1/362261 ,  A61M1/3638 ,  A61M60/892 ,  A61M60/894 ,  A61M2205/12 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65 ,  Y02A50/30 ,  Y02A90/10

摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

公开(公告)号：US11964083B2

公开(公告)日：2024-04-23

申请号：US16077532

申请日：2017-02-06

申请人： NIKKISO CO., LTD.

发明人： Hiroshi Nimura ,  Yoshimichi Masuda ,  Masato Fujiwara

IPC分类号： A61M1/16 ,  A61M1/14 ,  A61M1/26 ,  A61M1/36

CPC分类号： A61M1/1621 ,  A61M1/15632 ,  A61M1/16 ,  A61M1/1652 ,  A61M1/1668 ,  A61M1/267 ,  A61M1/36226 ,  A61M1/362264 ,  A61M1/3626 ,  A61M1/3639 ,  A61M1/3663 ,  A61M1/36222 ,  A61M2205/12 ,  A61M2205/14 ,  A61M2205/6018

摘要： This extracorporeal circulation cassette is provided with: a blood circuit (10) comprising a flexible tube and having a blood tube access portion set in a predetermined position in a device; a dialysate circuit (12) comprising a flexible tube and having a dialysate tube access portion set in a predetermined position in the device; a first panel (4) and a second panel (6) that are rigid and that integrate the blood circuit (10) and the dialysate circuit (12) while sandwiching the blood circuit (10) and the dialysate circuit (12) from both sides; and a window portion formed in a part of at least one of the first panel (4) and the second panel (6), disposed in a predetermined position in the device. The blood tube access portion and the dialysate tube access portion are positioned in the window portion.

公开(公告)号：US20240024546A1

公开(公告)日：2024-01-25

申请号：US17814549

申请日：2022-07-25

申请人： William M. Gosney ,  Dale B. Nixon

发明人： William M. Gosney ,  Dale B. Nixon

IPC分类号： A61M1/36 ,  A61M60/113 ,  A61M60/279 ,  A61M60/36

CPC分类号： A61M1/36226 ,  A61M1/3672 ,  A61M60/113 ,  A61M60/279 ,  A61M60/36

摘要： An apparatus for locating and venting pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, a pump is operated to move the identified cells to a processing zone. When each identified cell reaches the processing zone, a control voltage is generated to open a valve to vent the identified pathogen cells. The pump refills the cassette holding chambers, returns the processed blood to the patient, and the procedure is repeated for a treatment time period.