公开(公告)号：US20240123127A1

公开(公告)日：2024-04-18

申请号：US18277640

申请日：2022-02-10

申请人： GAMBRO LUNDIA AB

发明人： Paolo Rovatti ,  Alessandro Surace

IPC分类号： A61M1/16

CPC分类号： A61M1/1613 ,  A61M1/1607 ,  A61M1/1611 ,  A61M2205/3303 ,  A61M2205/3334 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/20

摘要： A control unit of an apparatus for extracorporeal blood treatment is configured to perform a control procedure comprising: calculating parameter control values to be set during a time interval after the instant in which the control is made, on the basis of actual values and of prescription values of variation in blood volume, ultrafiltration flow rate, concentration of sodium and/or potassium and heart rate or variation of heart rate of the patient; imposing the parameter control values during the time interval consecutive to the instant in which the control is made such that the actual values of the variation in blood volume track the prescription values of the variation in blood volume over a predetermined treatment time and the actual values of the heart rate or variation of heart rate track the prescription values of the heart rate or variation of heart rate over the predetermined treatment time.

公开(公告)号：US11951243B2

公开(公告)日：2024-04-09

申请号：US17943377

申请日：2022-09-13

申请人： Fresenius Medical Care Holdings, Inc.

发明人： Vaibhav Maheshwari ,  Peter Kotanko

IPC分类号： A61M1/34 ,  A61M1/16 ,  A61M5/142 ,  G06F9/30 ,  G06F15/16 ,  G06F15/163 ,  G06F15/167 ,  G06F17/11 ,  A61M1/28

CPC分类号： A61M1/3406 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/1615 ,  A61M1/1676 ,  A61M1/342 ,  A61M1/3424 ,  A61M1/3441 ,  A61M1/3455 ,  A61M1/3458 ,  A61M5/142 ,  G06F9/30 ,  G06F9/30003 ,  G06F15/16 ,  G06F15/163 ,  G06F15/167 ,  G06F17/11 ,  A61M1/1654 ,  A61M1/287 ,  A61M1/3493 ,  A61M2205/52

摘要： Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to access dialysis information for a dialysis process performed by a dialysis machine, the dialysis information indicating a target substance to be displaced from a binding compound by a displacer, and determine an infusion profile for infusing the displacer into a patient during a displacer infusion process of the dialysis process, the infusion profile determined based on the dialysis information and an infusion constraint. Other embodiments are described.

公开(公告)号：US11850341B2

公开(公告)日：2023-12-26

申请号：US17879455

申请日：2022-08-02

申请人： NxStage Medical, Inc.

发明人： Jeffrey H. Burbank ,  Dennis M. Treu ,  Daniel Joseph Rubery, Jr. ,  Scott W. Newell ,  James M. Brugger ,  William J. Schnell ,  William K. Weigel ,  Steven A. White ,  Mark T. Wyeth ,  Jerome James ,  David Desouza ,  Joseph E. Turk, Jr. ,  Garrett Casey

IPC分类号： A61M1/14 ,  A61M1/34 ,  A61M1/16 ,  A61M1/36

CPC分类号： A61M1/1605 ,  A61M1/14 ,  A61M1/165 ,  A61M1/1613 ,  A61M1/1615 ,  A61M1/1647 ,  A61M1/341 ,  A61M1/3403 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3448 ,  A61M1/3609 ,  A61M1/3635 ,  A61M1/34 ,  A61M1/3607 ,  A61M2205/05 ,  A61M2205/058 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3365 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/702

摘要： The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

公开(公告)号：US20230390467A1

公开(公告)日：2023-12-07

申请号：US18330780

申请日：2023-06-07

申请人： INNCELEREX

发明人： Parviz GHAHRAMANI

IPC分类号： A61M1/16 ,  G16H20/10 ,  G09B23/28

CPC分类号： A61M1/1613 ,  A61M1/1621 ,  G16H20/10 ,  G09B23/28 ,  A61M2205/50

摘要： Systems, methods, and devices model, identify, and predict effects of dialysis on drugs and chemical substances in patients. The systems estimate and determine effects of dialysis on elutes and drugs and solve problems with prior systems in determining effects of dialysis on drugs and dosages, especially the removal of target substances from the blood of patients during dialysis. Drug and medicine dosage adjustments for patients undergoing dialysis are made by considering the dialysis systems, patients, and drug variables and the extent to which they affect drug removal. Patients receive proper dosing by accounting for the effects of their dialysis. Systems and methods include a combination of ex vivo simulated treatments and in-silico modeling and simulation. The effects of dialysis are estimated and determined for various drugs and dosages. A reliable and effective surrogate for performing studies on patients provides guidance for use of the drugs in dialysis patients.

公开(公告)号：US20190231956A1

公开(公告)日：2019-08-01

申请号：US16381354

申请日：2019-04-11

申请人： NxStage Medical, Inc.

发明人： Jeffrey H. BURBANK ,  Dennis M. TREU ,  Daniel J. RUBERY, JR. ,  Scott W. NEWELL ,  James M. BRUGGER ,  William J. SCHNELL ,  William K. WEIGEL ,  Steven A. WHITE ,  Mark T. WYETH ,  Jerome JAMES ,  David DESOUZA ,  Joseph E. TURK, JR. ,  Garrett CASEY

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/14 ,  A61M1/36

CPC分类号： A61M1/1605 ,  A61M1/14 ,  A61M1/1613 ,  A61M1/1615 ,  A61M1/1647 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3448 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/3635 ,  A61M2205/058 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3365 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/702

摘要： The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

公开(公告)号：US10052423B2

公开(公告)日：2018-08-21

申请号：US14342025

申请日：2012-08-23

申请人： Dominique Pouchoulin

发明人： Dominique Pouchoulin

IPC分类号： A61M1/16 ,  G01F1/00 ,  G06F19/00 ,  A61M1/34 ,  A61M1/36

CPC分类号： A61M1/1613 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3406 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/3607 ,  A61M1/3609 ,  A61M2202/0413 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/75 ,  G01F1/00 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

摘要： An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates based on a fluid flow rate set by the operator and on a prescribed dose value (Dset).

公开(公告)号：US09931452B2

公开(公告)日：2018-04-03

申请号：US14386062

申请日：2013-03-20

申请人： GAMBRO LUNDIA AB

发明人： Dominique Pouchoulin

IPC分类号： A61M1/16

CPC分类号： A61M1/1605 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/1643 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3396 ,  A61M2205/50

摘要： Blood treatment apparatus and methods of using the same are described herein that include two or more intermediate containers located between a treatment solution source and a port through which the treatment solution is to be delivered with the blood treatment apparatus. The weight of the intermediate containers is measured and used to control the refilling and emptying of treatment solution in the intermediate containers.

公开(公告)号：US09925321B2

公开(公告)日：2018-03-27

申请号：US14654066

申请日：2013-12-16

申请人： GAMBRO LUNDIA AB

发明人： Alessandro Surace ,  Paolo Rovatti

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/36

CPC分类号： A61M1/1613 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1605 ,  A61M1/1611 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/36 ,  A61M1/3607 ,  A61M2205/3303 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2230/20 ,  A61M2230/65

摘要： It is disclosed an apparatus for extracorporeal blood treatment (1) having a control unit (15) connected to an ultrafiltration device (20) and to a fluid preparation section (30) of fresh dialysis liquid. The control unit (15) is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV %mes(t); UFmes(t), WLmes(t); Cbmes(t)); the control unit (15) is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

公开(公告)号：US20170333616A1

公开(公告)日：2017-11-23

申请号：US15667243

申请日：2017-08-02

申请人： Gambro Lundia AB

发明人： Alessandro Vasta

IPC分类号： A61M1/36 ,  A61M1/34 ,  A61M1/16

CPC分类号： A61M1/3663 ,  A61M1/16 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/36 ,  A61M1/3607 ,  A61M1/3624 ,  A61M1/3627 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3365 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/3389

摘要： An apparatus is described for extracorporeal blood treatment, comprising a treatment unit, an extracorporeal blood circuit and a fluid evacuation line. The apparatus comprises a control unit connected to a pressure sensor and a blood pump, the blood pump generating a variable flow with a constant component and a variable component. The control unit receives, from the pressure sensor, a plurality of values and calculates the average pressure value, acquires an estimated value of volume variation in the expansion chamber connected to the variable flow component, calculates, as a function of the pressure values, an estimated value of pressure variation in the expansion chamber that is representative of an oscillating pressure component and determines a representative magnitude of a blood level in the expansion chamber as a function of the average pressure value, the estimated value of volume variation and the estimated pressure variation in the expansion chamber.

公开(公告)号：US09713666B2

公开(公告)日：2017-07-25

申请号：US13836538

申请日：2013-03-15

申请人： Medtronic, Inc.

发明人： Bryant J. Pudil ,  Thomas E. Meyer ,  David B. Lura ,  Martin T. Gerber

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/14 ,  B01D15/08 ,  B01D15/36 ,  A61M1/28

CPC分类号： A61M1/1696 ,  A61M1/14 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/165 ,  A61M1/1694 ,  A61M1/28 ,  A61M1/3406 ,  A61M1/3472 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  B01D15/08 ,  B01D15/362

摘要： A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.