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公开(公告)号：US11383012B2
公开(公告)日：2022-07-12
申请号：US16463788
申请日：2017-10-26
申请人： GAMBRO LUNDIA AB
发明人： Anders Wallenborg , Anders Nilsson , Kristian Solem , Thomas Hertz , Paolo Rovatti , Carlo Alberto Lodi , Alessandro Surace , Jan Sternby
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
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公开(公告)号：US11883571B2
公开(公告)日：2024-01-30
申请号：US16849456
申请日：2020-04-15
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Carlo Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/3609 , A61M2205/3317
摘要： An extracorporeal blood treatment apparatus includes a filtration unit (2) connected to a blood circuit (17) and a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating of the dialysis fluid up to the calculating of the initial plasma conductivity performed by maintaining the dialysis fluid conductivity substantially constant.
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3.发明申请公开(公告)号：US20150290382A1
公开(公告)日：2015-10-15
申请号：US14441897
申请日：2013-10-28
申请人： GAMBRO LUNDIA AB
CPC分类号： A61M1/367 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/1617 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/3393 , A61M2209/02 , G05B13/04 , G05D7/0617 , G06F17/10
摘要： An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. The value of the effectiveness parameter is calculated using one or more values representative of the conductivity in the spent dialysate line obtained relying on a mathematical model.
摘要翻译： 一种用于体外血液处理的装置（1），包括处理单元，抽血管线，血液回流管线，制备管线和用过的透析液管线。 控制单元（10）被配置为基于用过的透析液线中的电导率的测量来计算与治疗有效性有关的参数的值。 使用代表根据数学模型获得的用过的透析液线中的电导率的一个或多个值来计算有效性参数的值。
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公开(公告)号：US10646632B2
公开(公告)日：2020-05-12
申请号：US15574956
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Carlo Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.
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公开(公告)号：US10265459B2
公开(公告)日：2019-04-23
申请号：US15911448
申请日：2018-03-05
申请人： Gambro Lundia AB
摘要： An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. The value of the effectiveness parameter is calculated using one or more values representative of the conductivity in the spent dialysate line obtained relying on a mathematical model.
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公开(公告)号：US20180140761A1
公开(公告)日：2018-05-24
申请号：US15575089
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Cario Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
CPC分类号： A61M1/1605 , A61M1/1607 , A61M1/1609 , A61M1/1656 , A61M1/1666 , A61M1/3406 , A61M1/3609 , A61M2205/128 , A61M2230/005 , A61M2230/20 , A61M2230/65
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
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公开(公告)号：US12121640B2
公开(公告)日：2024-10-22
申请号：US17418090
申请日：2019-12-27
申请人： GAMBRO LUNDIA AB
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36 , A61M60/113 , A61M60/279 , A61M60/37 , G16H10/40 , G16H20/40
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/1656 , A61M1/3413 , A61M1/3417 , A61M1/3661 , A61M60/113 , A61M60/279 , A61M60/37 , G16H10/40 , G16H20/40 , A61M2205/3317 , A61M2205/3334 , A61M2230/20
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line at a set point based on the physician prescription; starting from the initial patient plasma conductivity, estimated at the beginning of the treatment, and based on the target plasma conductivity/sodium concentration which is equivalent to the dialysate conductivity/sodium concentration prescribed, the control unit determines the minimum constant gradient between dialysis fluid and plasma conductivity/concentration to be maintained during treatment to achieve the conductivity/concentration target in the patient plasma at the end of the session.
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公开(公告)号：US11426501B2
公开(公告)日：2022-08-30
申请号：US16463781
申请日：2017-10-27
申请人： GAMBRO LUNDIA AB
发明人： Anders Wallenborg , Anders Nilsson , Kristian Solem , Thomas Hertz , Paolo Rovatti , Carlo Alberto Lodi , Alessandro Surace , Jan Sternby
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.
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公开(公告)号：US10434236B2
公开(公告)日：2019-10-08
申请号：US15575089
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Carlo Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
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10.发明申请公开(公告)号：US20180193547A1
公开(公告)日：2018-07-12
申请号：US15911448
申请日：2018-03-05
申请人： Gambro Lundia AB
CPC分类号： A61M1/367 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/1617 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/3393 , A61M2209/02 , G05B13/04 , G05D7/0617 , G06F17/10
摘要： An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. The value of the effectiveness parameter is calculated using one or more values representative of the conductivity in the spent dialysate line obtained relying on a mathematical model.
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