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公开(公告)号：US11883571B2
公开(公告)日：2024-01-30
申请号：US16849456
申请日：2020-04-15
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Carlo Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/3609 , A61M2205/3317
摘要： An extracorporeal blood treatment apparatus includes a filtration unit (2) connected to a blood circuit (17) and a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating of the dialysis fluid up to the calculating of the initial plasma conductivity performed by maintaining the dialysis fluid conductivity substantially constant.
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公开(公告)号：US11426501B2
公开(公告)日：2022-08-30
申请号：US16463781
申请日：2017-10-27
申请人： GAMBRO LUNDIA AB
发明人： Anders Wallenborg , Anders Nilsson , Kristian Solem , Thomas Hertz , Paolo Rovatti , Carlo Alberto Lodi , Alessandro Surace , Jan Sternby
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.
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公开(公告)号：US10434236B2
公开(公告)日：2019-10-08
申请号：US15575089
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Carlo Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
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公开(公告)号：US20150306293A1
公开(公告)日：2015-10-29
申请号：US14651730
申请日：2013-12-11
申请人： GAMBRO LUNDIA AB
发明人： Jan Sternby , Mattias Holmer , Bo Olde , Kristian Solem , Anders Wallenborg , Per Hansson
IPC分类号： A61M1/14
CPC分类号： A61M1/14 , A61B5/7217 , A61M1/1605 , A61M1/1613 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/15 , A61M2205/3303 , A61M2205/3331 , A61M2205/3344 , A61M2205/50 , A61M2230/04 , B01D61/30 , B01D61/32
摘要： A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (1b). A pulse detection block (54) processes the filtered signal (yf) for detection of subject pulses originating from the subject.
摘要翻译： 监测装置（7）对来自血液处理装置的压力信号进行操作。 透析机具有连接到受试者的血管系统的体外血液回路，用于通过透析器泵血，以及用于通过透析器泵送治疗流体的治疗液供给系统。 监测装置（7）具有用于从体外血液回路中的第一压力传感器（6a）获得第一压力信号（y）的第一输入块（50）和用于获得第二压力 来自处理液供给系统中的第二压力传感器（6b）的信号（w）。 仿真块（56）根据第二压力信号（w）产生模拟第一压力传感器（6a）的并行信号响应的仿真第一压力信号（y）和滤波块（53）， 根据第一压力信号（y）和仿真的第一压力信号（y）产生滤波信号（y），以便抑制与第一压力信号（y）相比的滤波信号（y） 来自治疗液供给系统（1b）的信号干扰。 脉冲检测块（54）处理用于检测从被摄体发出的被摄体脉冲的滤波信号（yf）。
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公开(公告)号：US11383012B2
公开(公告)日：2022-07-12
申请号：US16463788
申请日：2017-10-26
申请人： GAMBRO LUNDIA AB
发明人： Anders Wallenborg , Anders Nilsson , Kristian Solem , Thomas Hertz , Paolo Rovatti , Carlo Alberto Lodi , Alessandro Surace , Jan Sternby
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
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公开(公告)号：US20190046709A1
公开(公告)日：2019-02-14
申请号：US16160398
申请日：2018-10-15
申请人： GAMBRO LUNDIA AB
发明人： Jan Sternby , Mattias Holmer , Bo Olde , Kristian Solem , Anders Wallenborg , Per Hansson
CPC分类号： A61M1/14 , A61B5/7217 , A61M1/1605 , A61M1/1613 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/15 , A61M2205/3303 , A61M2205/3331 , A61M2205/3344 , A61M2205/50 , A61M2230/04 , B01D61/30 , B01D61/32
摘要： A monitoring device operates on a pressure signal from a blood processing apparatus which has an extracorporeal blood circuit for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device has a first input block for obtaining a first pressure signal, and a second input block for obtaining a second pressure signal. An emulation block generates, as a function of the second pressure signal, an emulated first pressure signal which emulates a concurrent signal response of the first pressure sensor, and a filtering block generates a filtered signal as a function of the first pressure signal and the emulated first pressure signal, so as to suppress, in the filtered signal compared to the first pressure signal, signal interferences originating from the treatment fluid supply system. A pulse detection block processes the filtered signal for detection of subject pulses.
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公开(公告)号：US10137233B2
公开(公告)日：2018-11-27
申请号：US14651730
申请日：2013-12-11
申请人： GAMBRO LUNDIA AB
发明人： Jan Sternby , Mattias Holmer , Bo Olde , Kristian Solem , Anders Wallenborg , Per Hansson
摘要： A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (1b). A pulse detection block (54) processes the filtered signal (yf) for detection of subject pulses originating from the subject.
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公开(公告)号：US11690946B2
公开(公告)日：2023-07-04
申请号：US17242877
申请日：2021-04-28
申请人： GAMBRO LUNDIA AB
发明人： Per Hansson , Thomas Hertz , Mattias Holmer , Lennart Jonsson , Anders Nilsson , Anders Wallenborg , Johan Andersson
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus is disclosed. The example apparatus includes a blood treatment unit including a fluid inlet and a fluid outlet and a blood line. The apparatus also includes a fluid line including an upstream fluid line configured to receive electrically conductive treatment fluid from a fluid source and pass the electrically conductive treatment fluid to the fluid inlet of the blood treatment unit and a downstream fluid line connected to the fluid outlet of the blood treatment unit for delivering the used electrically conductive treatment fluid to a fluid sink. The apparatus further includes a flow divider arranged in the downstream fluid line and configured to separate the used electrically conductive treatment fluid in the downstream fluid line into to a first fluid section and a second fluid section, thereby electrically isolating the first and second fluid sections.
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公开(公告)号：US20190275230A1
公开(公告)日：2019-09-12
申请号：US16463788
申请日：2017-10-26
申请人： GAMBRO LUNDIA AB
发明人： Anders Wallenborg , Anders Nilsson , Kristian Solem , Thomas Hertz , Paolo Rovatti , Carlo Alberto Lodi , Alessandro Surace , Jan Sternby
IPC分类号： A61M1/34
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
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公开(公告)号：US11975130B2
公开(公告)日：2024-05-07
申请号：US16621629
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： Roger Nilsson , Björn Ericson , Jan Sternby , Thomas Hertz , Olof Jansson , Sture Hobro , Anders Wallenborg , Jonas Fors , Henrik Lindgren , Annmargret Håkansson
CPC分类号： A61M1/1609 , A61M1/304 , A61M1/367
摘要： A system and a method for renal replacement therapy includes a blood treatment unit connected to a blood circuit and a dialysis fluid circuit, the system further including a control unit configured to control the system according to control instructions during a treatment, so as to determine a system parameter value and an indication of membrane fouling of the membrane, and activate an automatic anti-fouling measure that includes a temporary change of the flow rate in the blood circuit and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.
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