公开(公告)号：US11426501B2

公开(公告)日：2022-08-30

申请号：US16463781

申请日：2017-10-27

申请人： GAMBRO LUNDIA AB

发明人： Anders Wallenborg ,  Anders Nilsson ,  Kristian Solem ,  Thomas Hertz ,  Paolo Rovatti ,  Carlo Alberto Lodi ,  Alessandro Surace ,  Jan Sternby

IPC分类号： A61M1/16 ,  A61M1/34 ,  B01D61/32 ,  A61M1/36

摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

公开(公告)号：US10434236B2

公开(公告)日：2019-10-08

申请号：US15575089

申请日：2016-05-23

申请人： GAMBRO LUNDIA AB

发明人： Paolo Rovatti ,  Alessandro Surace ,  Carlo Alberto Lodi ,  Anders Wallenborg ,  Anders Nilsson ,  Kristian Solem ,  Jan Sternby ,  Thomas Hertz

IPC分类号： B01D11/00 ,  B01D61/00 ,  A61M1/16 ,  A61M1/34 ,  C02F1/44 ,  A61M1/36

摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

公开(公告)号：US20160356667A1

公开(公告)日：2016-12-08

申请号：US15240421

申请日：2016-08-18

申请人： GAMBRO LUNDIA AB

发明人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

IPC分类号： G01M3/28 ,  A61M1/36

CPC分类号： G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

摘要： A method of monitoring the integrity of a fluid connection between first and second fluid containing systems based on at least one time-dependent measurement signal from a pressure sensor in the first fluid containing system. The pressure sensor detects first pulses originating from a first pulse generator in the first fluid containing system and second pulses originating from a second pulse generator in the second fluid containing system. A parameter value representing a distribution of signal values within a time window is calculated by analyzing the measurement signal in the time domain and/or by using information on the timing of the second pulses in the measurement signal. The parameter value may be calculated as a statistical dispersion measure of the signal values, or from matching the signal to a predicted temporal signal profile of the second pulse. The integrity of the fluid connection is determined from the parameter value.

摘要翻译： 基于来自第一流体容纳系统中的压力传感器的至少一个与时间相关的测量信号来监测第一和第二流体容纳系统之间的流体连接的完整性的方法。 压力传感器检测来自第一流体容纳系统中的第一脉冲发生器的第一脉冲和源自第二流体容纳系统中的第二脉冲发生器的第二脉冲。 通过在时域中分析测量信号和/或通过使用关于测量信号中的第二脉冲的定时的信息来计算表示时间窗内的信号值分布的参数值。 可以将参数值计算为信号值的统计色散测量值，或者将信号与第二脉冲的预测时间信号分布匹配。 根据参数值确定流体连接的完整性。

公开(公告)号：US20160310657A1

公开(公告)日：2016-10-27

申请号：US15104861

申请日：2014-12-09

申请人： GAMBRO LUNDIA AB

发明人： Kristian Solem ,  David Stefani ,  Sture Hobro ,  Bo Olde

IPC分类号： A61M1/36 ,  G01F23/14

CPC分类号： A61M1/3627 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/367 ,  A61M2205/123 ,  A61M2205/3331 ,  A61M2205/3386 ,  A61M2205/3389 ,  G01F23/14 ,  G01F23/18

摘要： An apparatus (1) is described for extracorporeal blood treatment, comprising a treatment unit (2), an extracorporeal blood circuit (8) and a fluid evacuation line (10). A venous chamber (12) is placed in a blood return line (7) and is arranged in use to contain a gas in an upper portion (120) and blood at a predetermined level in a lower portion. The apparatus (1) comprises a control unit (21) connected to a first pressure sensor (14) and configured to: receive from the first pressure sensor (14) a first signal (P1(t)) relating to a time variable pressure (P(t)) of the blood flow; calculate a phase shift (θ) between the first signal (P1(t)) and a reference signal (P2(t)) correlated to the time variable pressure (P(t)) detected at a location distinct from the upper portion (120) of the chamber (12); monitor the volume (V) of gas in the upper portion (120) of the chamber (12) through the phase shift (θ).

摘要翻译： 一种用于体外血液处理的装置（1），其包括处理单元（2），体外血液回路（8）和排液管线（10）。 静脉腔室（12）被放置在血液返回管线（7）中，并且在使用中被布置成在上部（120）中容纳气体，并在下部容纳预定水平的血液。 装置（1）包括连接到第一压力传感器（14）并被配置为：从第一压力传感器（14）接收与时间可变压力相关的第一信号（P1（t））的控制单元（21） P（t））; 计算第一信号（P1（t））和与在与上部不同的位置处检测到的时间可变压力（P（t））相关的参考信号（P2（t））之间的相移（θ） ）; 通过相移（θ）监测室（12）的上部（120）中的气体的体积（V）。

公开(公告)号：US20160270733A1

公开(公告)日：2016-09-22

申请号：US14777695

申请日：2014-03-17

申请人： GAMBRO LUNDIA AB

发明人： Per Hansson ,  Bo Olde ,  Kristian Solem ,  Jan Sternby

IPC分类号： A61B5/00 ,  A61B5/021 ,  A61M1/36 ,  A61B5/0215

CPC分类号： A61B5/6866 ,  A61B5/02125 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/4836 ,  A61B5/7246 ,  A61B5/7282 ,  A61B5/746 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M1/369 ,  A61M2230/04

摘要： A monitoring device (7) operates an input block (30) to acquire a pressure signal from a pressure sensor (6a-6c) in an apparatus for extracorporeal blood processing connected to the vascular system of the subject. A processing block (34) repeatedly processes the pressure signal for generation of a time-sequence of parameter values indicative of pressure pulsations originating from heartbeats in the subject, and an evaluation block (35) evaluates the parameter values for detection of cardiac arrest and, if cardiac arrest is detected, generates a dedicated alarm signal. To reduce the risk for false positives without increasing the risk for false negatives, the monitoring device (7) may acquire and process more than one pressure signal, and/or perform an initial viability check before the monitoring is initiated to ensure that pressure pulsations originating from heartbeats are detectable in the pressure signal(s), and/or separate the monitoring of the pressure signal(s) into a detection phase performed during regular operation of a blood pump in the apparatus, and a verification phase performed during a temporary shutdown of the blood pump.

摘要翻译： 监视装置（7）操作输入块（30）以从连接到对象的血管系统的用于体外血液处理的装置中的压力传感器（6a-6c）获取压力信号。 处理块（34）重复地处理压力信号以产生指示受试者心跳的压力脉动的参数值的时间序列，并且评估块（35）评估用于检测心跳骤停的参数值， 如果检测到心跳停止，则产生专用报警信号。 为了降低假阳性风险，而不增加假阴性的风险，监测装置（7）可以在开始监测之前获取并处理多于一个压力信号和/或执行初始生存力检查，以确保起始的压力脉动 在压力信号中可以检测到心跳，和/或将压力信号的监测分离成在装置中的血泵的常规操作期间执行的检测阶段，以及在临时关闭期间执行的验证阶段 的血泵。

公开(公告)号：US20150306293A1

公开(公告)日：2015-10-29

申请号：US14651730

申请日：2013-12-11

申请人： GAMBRO LUNDIA AB

发明人： Jan Sternby ,  Mattias Holmer ,  Bo Olde ,  Kristian Solem ,  Anders Wallenborg ,  Per Hansson

IPC分类号： A61M1/14

CPC分类号： A61M1/14 ,  A61B5/7217 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/3303 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/50 ,  A61M2230/04 ,  B01D61/30 ,  B01D61/32

摘要： A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (1b). A pulse detection block (54) processes the filtered signal (yf) for detection of subject pulses originating from the subject.

摘要翻译： 监测装置（7）对来自血液处理装置的压力信号进行操作。 透析机具有连接到受试者的血管系统的体外血液回路，用于通过透析器泵血，以及用于通过透析器泵送治疗流体的治疗液供给系统。 监测装置（7）具有用于从体外血液回路中的第一压力传感器（6a）获得第一压力信号（y）的第一输入块（50）和用于获得第二压力 来自处理液供给系统中的第二压力传感器（6b）的信号（w）。 仿真块（56）根据第二压力信号（w）产生模拟第一压力传感器（6a）的并行信号响应的仿真第一压力信号（y）和滤波块（53）， 根据第一压力信号（y）和仿真的第一压力信号（y）产生滤波信号（y），以便抑制与第一压力信号（y）相比的滤波信号（y） 来自治疗液供给系统（1b）的信号干扰。 脉冲检测块（54）处理用于检测从被摄体发出的被摄体脉冲的滤波信号（yf）。

公开(公告)号：US08805487B2

公开(公告)日：2014-08-12

申请号：US13645594

申请日：2012-10-05

申请人： Gambro Lundia AB

发明人： Leif Sömmo ,  Kristian Solem

IPC分类号： A61B5/02 ,  A61B5/00 ,  A61B5/0452 ,  A61B5/0402 ,  A61M1/30

CPC分类号： A61B5/746 ,  A61B5/0402 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7264 ,  A61M1/30

摘要： A cardiac-activity based prediction of a rapid drop in a patient's blood pressure during extracorporeal blood treatment is disclosed. A proposed alarm apparatus includes a primary beat morphology analysis unit bank of secondary analysis units and an alarm generating unit. The primary beat morphology analysis unit discriminates heart beats in a received basic electrocardiogram signal, classifies each beat into one out of at least two different beat categories, and associates each segment of the signal with relevant event-type data. The event-type data and the basic electrocardiogram signal together form an enhanced electrocardiogram signal, based upon which the primary beat morphology analysis unit determines whether one or more secondary signal analyses should be performed. Depending on the enhanced electrocardiogram signal's properties, the bank of secondary analysis units performs none, one or more of up to at least two different types of secondary analyses, and for each analysis performed produces a respective test signal. The alarm generating unit receives the test signals, and triggers an alarm signal indicative of an estimated rapid blood pressure decrease, if at least one alarm criterion is fulfilled.

摘要翻译： 公开了一种基于心脏活动的预测体外血液治疗期间患者血压迅速下降的预测。 所提出的报警装置包括二次分析单元的主拍形态分析单元组和报警发生单元。 主要搏动形态分析单元鉴别接收到的基本心电图信号中的心跳，将每个节拍分为至少两个不同节拍类别中的一个，并将每个信号段与相关的事件类型数据相关联。 事件类型数据和基本心电图信号一起形成增强的心电图信号，基于该心电图信号，初步搏动形态分析单元确定是否应执行一个或多个次要信号分析。 根据增强的心电图信号的性质，二次分析单元组不执行至多两种不同类型的辅助分析中的一个或多个，并且对于执行的每个分析，都产生相应的测试信号。 如果满足至少一个报警标准，则报警发生单元接收测试信号，并触发指示估计的快速血压下降的报警信号。

公开(公告)号：US11883571B2

公开(公告)日：2024-01-30

申请号：US16849456

申请日：2020-04-15

申请人： GAMBRO LUNDIA AB

发明人： Paolo Rovatti ,  Alessandro Surace ,  Carlo Alberto Lodi ,  Anders Wallenborg ,  Anders Nilsson ,  Kristian Solem ,  Jan Sternby ,  Thomas Hertz

IPC分类号： A61M1/16 ,  A61M1/36

CPC分类号： A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/3609 ,  A61M2205/3317

摘要： An extracorporeal blood treatment apparatus includes a filtration unit (2) connected to a blood circuit (17) and a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating of the dialysis fluid up to the calculating of the initial plasma conductivity performed by maintaining the dialysis fluid conductivity substantially constant.

公开(公告)号：US10314965B2

公开(公告)日：2019-06-11

申请号：US14917099

申请日：2014-09-08

申请人： GAMBRO LUNDIA AB

发明人： Mattias Holmer ,  Bo Olde ,  Kristian Solem ,  Leif Sornmo

IPC分类号： A61M1/00 ,  A61M1/36 ,  A61B5/00 ,  A61B5/021

摘要： A filtering device receives a signal from a pressure sensor in an extracorporeal fluid circuit connected to a subject and processes the signal to separate physiological pulses, e.g. from the subject's heart, from interference pulses, e.g. from a pump in the fluid circuit. The device repeatedly (iteratively) processes a signal segment by alternately subtracting (S3) a template signal from the signal segment, and applying a refinement processing (S6) to the resulting difference signal to generate a new template signal. By proper selection (S2) of the initial template signal, consecutive difference signals will alternately approximate the sequence of interference pulses in the signal segment and the sequence of physiological pulses in the signal segment. The refinement processing (S6) aims at alternately cleaning up unwanted residuals from interference pulses and physiological pulses, respectively, in the respective difference signal, so as to improve the accuracy of the template signal between the subtractions.

公开(公告)号：US20180055989A1

公开(公告)日：2018-03-01

申请号：US15798885

申请日：2017-10-31

申请人： GAMBRO LUNDIA AB

发明人： Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby ,  Anders Wieslander

IPC分类号： A61M1/36 ,  A61M1/30 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/00 ,  A61B5/021

CPC分类号： A61M1/3656 ,  A61B5/02125 ,  A61B5/0215 ,  A61B5/02405 ,  A61B5/4836 ,  A61M1/30 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3653 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/6018

摘要： A control system (23) is arranged to control the operation of an apparatus (200) for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.