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公开(公告)号：US11446417B2
公开(公告)日：2022-09-20
申请号：US16164047
申请日：2018-10-18
Applicant: NxStage Medical, Inc.
Inventor： Jeffrey H. Burbank , Dennis M. Treu , Christopher S. McDowell , Goetz Friederichs
IPC: A61M1/16 , B01D61/06 , B01D61/14 , B01D61/22 , B01D61/24 , B01D61/28 , C02F1/42 , C02F1/44 , B01D61/32 , C02F1/28 , A61M3/00 , C02F1/32 , C02F103/02
Abstract: A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient.
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公开(公告)号：US11376353B2
公开(公告)日：2022-07-05
申请号：US13512133
申请日：2010-11-16
Applicant: Pascal Kopperschmidt , Alfred Gagel
Inventor： Pascal Kopperschmidt , Alfred Gagel
Abstract: The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.
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公开(公告)号：US11311658B2
公开(公告)日：2022-04-26
申请号：US16871558
申请日：2020-05-11
Applicant: Baxter International Inc. , Baxter Healthcare SA
Inventor： Alex A. Yu , James Grayson , Robert W. Childers
Abstract: An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine configured to remove ultrafiltrate (“UF”) from a patient and record how much UF has been removed. The APD machine operates according to a prescription to remove the UF. The system also includes a server in communication with the APD machine. The server analyzes the UF data to determine if the prescription is to be modified to compensate for changes to the patient's renal function or renal transport characteristics.
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公开(公告)号：US11207451B2
公开(公告)日：2021-12-28
申请号：US16852877
申请日：2020-04-20
Applicant: GAMBRO LUNDIA AB
Inventor： Hiram Rada , Dominique Pouchoulin , Georges Vantard , Alain Frugier
Abstract: An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates by imposing that an emptying time of containers of fresh fluid (16, 20, 21, 26) and/or a filling time of a waste container is substantially same as, or multiple of, the emptying time of one or more of the other containers of fresh fluid.
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5.发明申请公开(公告)号：US20210259971A1
公开(公告)日：2021-08-26
申请号：US16760440
申请日：2018-10-31
Applicant: OSAKA UNIVERSITY
Inventor： Takashi MATSUZAKI
Abstract: The present invention provides a method for producing lipid particles that have a desired particle diameter, the method comprising: (A) a step for preparing, in a first mixing region, a primary dilution by mixing a first solution containing a lipid and an alcohol with a second solution containing water; (B) a step for feeding the primary dilution from the first mixing region to a second mixing region through a liquid feed pipe within a prescribed time; and (C) a step for preparing a secondary dilution by mixing the primary dilution with a third solution containing water in the second mixing region, wherein the steps (A)-(C) are continuously carried out, and the particle diameter of the lipid particles is controlled by adjusting at least one condition selected from the group consisting of the concentration of the alcohol and the concentration of the lipid in the primary dilution, the prescribed time, and the temperature during mixing.
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Patent Agency Ranking
公开(公告)号：US10881779B2
公开(公告)日：2021-01-05
申请号：US16448128
申请日：2019-06-21
Applicant: GAMBRO LUNDIA AB
Inventor： Mauro Suffritti , Michela Carpani
Abstract: An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9;9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber. A regulating device (20) of a transmembrane pressure is active on at least one of the lines and a control unit (15) is configured to: command the regulating device (20) by setting a first increase (δTMP1), determine a value of a control parameter (φ1) corresponding to the first increase, compare the value of the control parameter (φ1) with a reference value (φref) and, if the value of the control parameter is greater than the reference value, command the regulating device (20) by setting a second increase (δTMP2) which is greater than the first increase (δTMP1).
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公开(公告)号：US10850235B2
公开(公告)日：2020-12-01
申请号：US15177638
申请日：2016-06-09
Applicant: Minnetronix, Inc.
Inventor： Emily Rolfes Meyering , Gary Seim , Abhi Vase , Ben Krehbiel , Blake Hedstrom , Aaron McCabe
Abstract: Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.
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公开(公告)号：US10792618B2
公开(公告)日：2020-10-06
申请号：US16011683
申请日：2018-06-19
Applicant: Sartorius Stedim Biotech GmbH
Inventor： Thomas Erdenberger
Abstract: A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.
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公开(公告)号：US20200282124A1
公开(公告)日：2020-09-10
申请号：US16707839
申请日：2019-12-09
Applicant: DEKA Products Limited Partnership
Inventor： Kevin L. Grant , James D. Dale , Michael J. Wilt , Jason A. Demers , David E. Collins , Brian D. Tracey
Abstract: A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.
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公开(公告)号：US10646634B2
公开(公告)日：2020-05-12
申请号：US16141353
申请日：2018-09-25
Applicant: Baxter International Inc. , Baxter Healthcare SA
Inventor： Alex Anping Yu , James Grayson , Robert W. Childers
Abstract: An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine comprising a pumping mechanism and a peritoneal dialysis fluid heater. The example peritoneal dialysis system also includes a disposable set comprising a disposable cassette operable with the pumping mechanism and a heater bag operable with the heater. The example peritoneal dialysis system additionally includes a conductivity sensor positioned and arranged to provide feedback to the APD machine. The example APD machine is configured to mix a peritoneal dialysis fluid for treatment in the heater bag using a plurality of peritoneal dialysis constituent fluids. In addition, the example APD machine is configured to use feedback from the conductivity sensor to evaluate the mixed peritoneal dialysis fluid for treatment.
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