公开(公告)号：US11865240B2

公开(公告)日：2024-01-09

申请号：US17189879

申请日：2021-03-02

Applicant: NxStage Medical, Inc.

Inventor： Goetz Friederichs ,  Dennis M. Treu ,  Jeffrey H. Burbank ,  Yuriy N. Tatashin

IPC: A61M1/16 ,  C02F1/28 ,  C02F1/42 ,  C02F1/00 ,  C02F1/44 ,  C02F103/02 ,  C02F1/32 ,  C02F101/12

CPC classification number: A61M1/1656 ,  A61M1/1664 ,  A61M1/1666 ,  A61M1/1672 ,  C02F1/283 ,  C02F1/42 ,  C02F1/001 ,  C02F1/32 ,  C02F1/441 ,  C02F2001/427 ,  C02F2101/12 ,  C02F2103/026 ,  C02F2209/003 ,  C02F2209/02 ,  C02F2209/05 ,  C02F2209/29 ,  C02F2209/445

Abstract: A method of automatically ensuring against chloramine contamination in purified product water includes supplying input water to the system and purifying the water to generate the purified product water. The purifying includes removing chlorine and chloramine contamination from the water using a carbon filter and supplying chlorine-depleted water to a deionization filter, and deionizing the chlorine-depleted water using said deionization filter. The product water is supplied to a sensor for continuous monitoring of the resistivity of the purified product water by the first sensor, and an alarm is generated indicating possible chloramine breakthrough when the resistivity of the product water falls below a predetermined resistivity level, which is selected to provide a reserve filter capacity before breakthrough would occur. The carbon filter is replaced at least responsively to the alarm to ensure excess capacity of said carbon filter sufficient to prevent chloramine breakthrough in said product water.

公开(公告)号：US10960121B2

公开(公告)日：2021-03-30

申请号：US15924425

申请日：2018-03-19

Applicant: NxStage Medical, Inc.

Inventor： Goetz Friederichs ,  Dennis M. Treu ,  Jeffrey H. Burbank ,  Yuriy N. Tatashin

IPC: A61M1/16 ,  C02F1/28 ,  C02F1/42 ,  C02F1/00 ,  C02F1/44 ,  C02F103/02 ,  C02F1/32 ,  C02F101/12

Abstract: A method of automatically ensuring against chloramine contamination in purified product water includes supplying input water to the system and purifying the water to generate the purified product water. The purifying includes removing chlorine and chloramine contamination from the water using a carbon filter and supplying chlorine-depleted water to a deionization filter, and deionizing the chlorine-depleted water using said deionization filter. The product water is supplied to a sensor for continuous monitoring of the resistivity of the purified product water by the first sensor, and an alarm is generated indicating possible chloramine breakthrough when the resistivity of the product water falls below a predetermined resistivity level, which is selected to provide a reserve filter capacity before breakthrough would occur. The carbon filter is replaced at least responsively to the alarm to ensure excess capacity of said carbon filter sufficient to prevent chloramine breakthrough in said product water.

公开(公告)号：US10189728B2

公开(公告)日：2019-01-29

申请号：US15214438

申请日：2016-07-19

Applicant: NxStage Medical, Inc.

Inventor： Joseph Turk ,  William K. Weigel ,  Goetz Friederichs ,  Jeffery B. Hover

IPC: B01D61/42 ,  B01D61/54 ,  B01D65/02 ,  C02F1/469 ,  C02F1/44 ,  C02F1/00 ,  C02F1/32

Abstract: A fluid purification system has cells whose purifying capability can be regenerated. Some of the cells are arranged in series to reach a high level of purification. An automatic valve network is controlled to cycle the cells in a way that levels the loads on each, thereby maximizing the service interval for replacing expired cells, enabling all of the cells to be replaced at the same time after having each contributing approximately equally to the purification load, and operated such that at any one time, at least one cell is regenerated so as to enable continuous up-time.

公开(公告)号：US20130146541A1

公开(公告)日：2013-06-13

申请号：US13713767

申请日：2012-12-13

Applicant: NXSTAGE Medical, Inc.

Inventor： William K. Weigel ,  Goetz Friederichs ,  Joseph E. Turk ,  Jeffery B. Hover, SR.

IPC: C02F1/44

CPC classification number: C02F1/4695 ,  B01D61/42 ,  B01D61/52 ,  B01D61/54 ,  B01D65/02 ,  B01D2317/02 ,  B01D2321/04 ,  B01D2321/12 ,  C02F1/006 ,  C02F1/008 ,  C02F1/32 ,  C02F1/441 ,  C02F1/444 ,  C02F2201/46115 ,  C02F2201/4613 ,  C02F2201/46145 ,  C02F2209/003 ,  C02F2209/005 ,  C02F2209/40 ,  C02F2301/08 ,  C02F2303/16 ,  Y10T137/8593

Abstract: A fluid purification system has cells whose purifying capability can be regenerated. Some of the cells are arranged in series to reach a high level of purification. An automatic valve network is controlled to cycle the cells in a way that levels the loads on each, thereby maximizing the service interval for replacing expired cells, enabling all of the cells to be replaced at the same time after having each contributing approximately equally to the purification load, and operated such that at any one time, at least one cell is regenerated so as to enable continuous up-time.

Abstract translation: 流体净化系统具有能够再生净化能力的细胞。 一些细胞串联排列以达到高水平的纯化。 控制自动阀网络以使每个电池的负载平衡的方式循环电池，从而最大化用于替换过期电池的服务间隔，使得所有电池在每次贡献大致相等于之后同时被更换 净化负载，并且操作使得在任何一个时间，再生至少一个电池，以便能够连续正常运行。

公开(公告)号：US11986582B2

公开(公告)日：2024-05-21

申请号：US17511348

申请日：2021-10-26

Applicant: NxStage Medical, Inc.

Inventor： Goetz Friederichs ,  William K. Weigel ,  Dennis M. Treu ,  Jeffrey H. Burbank ,  James M. Brugger ,  Keith David J. Wheeler ,  Scott W. Newell

IPC: A61M1/16 ,  A61K31/191 ,  A61M1/14 ,  A61M1/36 ,  B01F21/20 ,  C02F9/00 ,  F15B1/04 ,  C02F1/20 ,  C02F1/28 ,  C02F1/42 ,  C02F1/44 ,  C02F103/02 ,  C02F103/04

CPC classification number: A61M1/1666 ,  A61K31/191 ,  A61M1/1524 ,  A61M1/154 ,  A61M1/155 ,  A61M1/1561 ,  A61M1/1562 ,  A61M1/1565 ,  A61M1/1658 ,  A61M1/166 ,  A61M1/362227 ,  A61M1/36224 ,  A61M1/36225 ,  A61M1/362261 ,  A61M1/362262 ,  A61M1/362265 ,  B01F21/20 ,  C02F9/00 ,  F15B1/04 ,  A61M1/1563 ,  A61M1/362263 ,  A61M2205/3317 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/6054 ,  A61M2205/6072 ,  C02F1/20 ,  C02F1/283 ,  C02F1/42 ,  C02F2001/425 ,  C02F2001/427 ,  C02F1/44 ,  C02F2103/026 ,  C02F2103/04 ,  C02F2209/05 ,  C02F2209/445 ,  F15B2201/315 ,  Y02A50/30

Abstract: A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

公开(公告)号：US11607482B2

公开(公告)日：2023-03-21

申请号：US17122772

申请日：2020-12-15

Applicant: NxStage Medical, Inc.

Inventor： David Desouza ,  Daniel Joseph Rubery, Jr. ,  Dennis M. Treu ,  Mark T. Wyeth ,  Jerome James ,  Garrett D. Casey ,  James M. Brugger ,  William J. Schnell ,  Jeffrey H. Burbank ,  Goetz Friederichs

IPC: A61M1/36 ,  A61M1/16

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

公开(公告)号：US11446417B2

公开(公告)日：2022-09-20

申请号：US16164047

申请日：2018-10-18

Applicant: NxStage Medical, Inc.

Inventor： Jeffrey H. Burbank ,  Dennis M. Treu ,  Christopher S. McDowell ,  Goetz Friederichs

IPC: A61M1/16 ,  B01D61/06 ,  B01D61/14 ,  B01D61/22 ,  B01D61/24 ,  B01D61/28 ,  C02F1/42 ,  C02F1/44 ,  B01D61/32 ,  C02F1/28 ,  A61M3/00 ,  C02F1/32 ,  C02F103/02

Abstract: A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient.

公开(公告)号：US10478544B2

公开(公告)日：2019-11-19

申请号：US15514230

申请日：2015-09-25

Applicant: NXSTAGE MEDICAL, INC.

Inventor： Goetz Friederichs ,  William Weigel ,  Dennis M. Treu ,  Jeffrey H. Burbank ,  James M. Brugger ,  Keith J. Wheeler ,  Scott W. Newell

IPC: A61M1/16 ,  A61K31/191 ,  B01F1/00 ,  C02F9/00 ,  F15B1/04 ,  C02F1/20 ,  C02F1/28 ,  C02F1/42 ,  C02F1/44 ,  C02F103/02 ,  C02F103/04

Abstract: A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.

公开(公告)号：US10189727B2

公开(公告)日：2019-01-29

申请号：US15187689

申请日：2016-06-20

Applicant: NxStage Medical, Inc.

Inventor： William K Weigel ,  Goetz Friederichs ,  Joseph E Turk ,  Jefferey B Hover, Sr.

IPC: B01D61/42 ,  B01D61/54 ,  B01D65/02 ,  C02F1/469 ,  C02F1/32 ,  C02F1/44 ,  C02F1/00 ,  B01D61/52

Abstract: A fluid purification system has cells whose purifying capability can be regenerated. Some of the cells are arranged in series to reach a high level of purification. An automatic valve network is controlled to cycle the cells in a way that levels the loads on each, thereby maximizing the service interval for replacing expired cells, enabling all of the cells to be replaced at the same time after having each contributing approximately equally to the purification load, and operated such that at any one time, at least one cell is regenerated so as to enable continuous up-time.

公开(公告)号：US12156958B2

公开(公告)日：2024-12-03

申请号：US18131898

申请日：2023-04-07

Applicant: NxStage Medical, Inc.

Inventor： James M. Brugger ,  Jeffrey H. Burbank ,  Goetz Friederichs ,  Scott W. Newell ,  William J. Schnell ,  Orlando Soto

IPC: A61M39/26 ,  A61M1/14 ,  A61M1/16 ,  G01N27/06 ,  G01N27/08 ,  G01R27/22

Abstract: A medicament preparation system includes a disposable cartridge with a flow path. Various sensors may be placed on the cartridge to measure qualities of the fluid flowing through the flow path. The sensors are placed in precise locations using various approaches that make manufacturing of the cartridge efficient and repeatable. A drain line that is susceptible to fouling may be preattached and various approaches are used to remove or reduce the fouling. An elastomeric contact can also be present in the medical preparation system and used in a conductivity measurement subsystem.