公开(公告)号：US20250050003A1

公开(公告)日：2025-02-13

申请号：US18722847

申请日：2022-12-06

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Karthik PITCHAIMANI ,  Anoop Thirumattathil ASHOKAN

IPC: A61M1/28

Abstract: A peritoneal dialysis (“PD”) system includes a disposable set including a pump chamber having a flexible sheet, one side of the flexible sheet positioned and arranged during operation to receive pneumatic pressure; and a cycler including at least one source of positive and negative pneumatic pressure for delivering pneumatic pressure to the pump chamber, an air flow sensor, a pneumatic pressure sensor, a temperature sensor, a plurality of fluid valves, and a control unit configured to integrate outputs from the air flow sensor, the pneumatic pressure sensor and the temperature sensor over time to determine an amount of fresh or used PD fluid discharged from the pump chamber under positive pneumatic pressure and via an open one of the plurality of fluid valves.

公开(公告)号：US20250050000A1

公开(公告)日：2025-02-13

申请号：US18719082

申请日：2022-12-14

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Olof JANSSON ,  Michael PETTERSSON ,  Thomas HERTZ ,  Jonas FORS ,  Per-Olof BORGQVIST

IPC: A61M1/16

Abstract: Ultrafiltration (UF) is monitored in a weight-based system for extracorporeal blood treatment. The system comprises a container holding a fluid that is pumped to or from a dialyzer by a pump. The container is intermittently refilled or drained by an adjustment arrangement during a level adjustment period (LAP). A scale measures the weight of the container. A monitoring device is operated to determine, before and after the LAP while the adjustment arrangement is deactivated and the pump is operated at a known setting, first and second values of a parameter of the pump based on a weight signal from the scale. The parameter may be flow rate or stroke volume. The monitoring device estimates a time profile for the parameter during the LAP based on the first and second values and determines the UF parameter based on the time profile.

公开(公告)号：US20250025614A1

公开(公告)日：2025-01-23

申请号：US18711451

申请日：2022-11-21

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Philipp KÜHN ,  Ralf FLIEG ,  Rainer BLICKLE ,  Steffen WAGNER

IPC: A61M1/16

Abstract: A peritoneal dialysis (“PD”) system (10) including a PD machine (20); a patient line (50) extending from the PD machine (20); and a filter set (100) in fluid communication with the patient line (50), the filter set (100) including a filter body (110, 150, 190) housing first and second filter membranes (112a, 112b, such as a sterilizing grade or bacteria reduction filter membranes), the filter body (110, 150, 190) configured to be placed in different arrangements such that fresh PD fluid (i) flows through the first filter membrane (112a) and then through the second filter membrane (112b) or (ii) splits and flows through first and second filter membranes (112a, 112b) in parallel.

公开(公告)号：US20250018101A1

公开(公告)日：2025-01-16

申请号：US18711427

申请日：2022-11-21

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Steffen WAGNER ,  Ralf FLIEG ,  Philipp KÜHN ,  Christof BECK ,  Rainer BLICKLE ,  Bernd KRAUSE

IPC: A61M1/16 ,  A61M1/28

Abstract: A peritoneal dialysis (“PD”) system (10) includes a PD machine (20); a patient line (50) extending from the PD machine (20); and a filter set (100) in fluid communication with the patient line (50), the filter set (100) including a filter membrane (120, e.g., a sterilizing grade filter membrane or a bacteria reduction filter membrane) positioned and arranged such that fresh PD fluid flows through the filter membrane (120) into a filtered fluid compartment (106f), wherein the filtered fluid compartment (106f) includes an outlet (1060) to a port (106p), and wherein the port (106p) is in fluid communication with a circumferential used PD fluid channel (106c) positioned and arranged to carry used PD fluid around the filter membrane (120) without contacting the filter membrane (120). A method for priming filter set (100) is also disclosed.

公开(公告)号：US20250001058A1

公开(公告)日：2025-01-02

申请号：US18707797

申请日：2022-11-11

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Lalu KRISHNAN

IPC: A61M1/16 ,  A61M1/28

Abstract: A peritoneal dialysis system includes a control unit configured to (i) store a sleep state pattern for the patient, (ii) begin a patient drain followed by a patient fill when at least one sensor indicates that the patient is in a deep sleep state, (iii) extend a dwell period if the sleep state pattern indicates that the patient will enter a subsequent deep sleep state within a first time duration after a programmed dwell period, and (iv) shorten the dwell period if the sleep state pattern indicates that the patient will leave the deep sleep state within a second time duration after an end of the programmed dwell period. The system alternatively or additionally assesses or records a stress level of and/or a fluid/caloric intake by the patient and takes actions accordingly.

公开(公告)号：US12171866B2

公开(公告)日：2024-12-24

申请号：US17059916

申请日：2019-05-29

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Laurent Jeannin ,  Julien Hecq

IPC: A61K9/10 ,  A23D7/005 ,  A23D7/01 ,  A23D7/06 ,  A23L33/00 ,  A23L33/11 ,  A23L33/12 ,  A23L33/125 ,  A23L33/175 ,  A61J1/10 ,  A61J1/20 ,  A61J3/00 ,  A61K9/00 ,  A61K9/107 ,  A61K31/14 ,  A61K31/202 ,  A61K31/232 ,  A61K31/661 ,  A61K31/685 ,  A61K33/12 ,  A61K36/05 ,  A61K47/10

Abstract: The present disclosure relates to parenteral nutritional formulations, including ready-to-use parenteral nutrition formulations. More particularly, the present disclosure is directed to lipid formulations or emulsions and multi-chamber containers comprising same, wherein the lipid emulsion contains glycerophosphorylcholine as a choline source. The present disclosure further relates to methods of providing choline to a patient in need of parenteral nutrition and methods of avoiding and/or treating choline deficiency and liver damage.

公开(公告)号：US20240416019A1

公开(公告)日：2024-12-19

申请号：US18715519

申请日：2022-11-30

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Oskar Erik Frode Styrbjorn FALLMAN

IPC: A61M1/28

Abstract: A peritoneal dialysis (“PD”) system includes a PD fluid pump, a PD fluid heater positioned and arranged to heat fresh PD fluid pumped by the PD fluid pump, and a phase change material (“PCM”) device positioned and arranged to receive fresh PD fluid heated by the PD fluid heater. The PCM device includes a PCM having a melting temperature selected so that the PCM solidifies when underheated fresh PD fluid contacts the PCM transferring heat to the underheated fresh PD fluid. Alternatively or additionally, the PD system may include a different PCM device having a PCM with a melting temperature selected so that the PCM melts when overheated fresh PD fluid contacts the PCM thereby removing heat from the overheated fresh PD fluid. A configuration for the PCM device is also disclosed.

公开(公告)号：US20240415924A1

公开(公告)日：2024-12-19

申请号：US18818119

申请日：2024-08-28

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Lindsay Wegiel ,  Reagan Miller

IPC: A61K38/12 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02 ,  A61K47/26

Abstract: In an aspect, a method of manufacture of a pharmaceutically acceptable solid composition containing daptomycin includes drying an aqueous solution containing (i) water, (ii) the daptomycin, (iii) sorbitol in an amount of about 1.2 wt. % to about 9.0 wt. % of total volume of the aqueous composition and (iv) mannitol in an amount of about 0.6 wt. % to about 9.5 wt. % of total volume of the aqueous composition to form the solid composition. The drying can include a sublimation drying of about −25° C. to about 50° C. for a time period of about 15 hours to about 120 hours, most preferably about 15° C. for about 20 hours, optionally preceded and/or followed by one or more additional drying steps. Other aspects are the solid composition containing the daptomycin and also methods of treating a bacterial infection including administering a pharmaceutically acceptable product made by reconstituting the solid composition.

公开(公告)号：US20240399038A1

公开(公告)日：2024-12-05

申请号：US18694800

申请日：2022-09-06

Applicant: Baxter International Inc. ,  Baxter Healthcare SA

Inventor： James White ,  Jonas Fors ,  Karl Henrik Forsland ,  Unberto Garcia ,  Steven Hanson ,  Scott Kopacek

IPC: A61M1/16

Abstract: A dialysis fluid production system includes a water purification unit, at least one concentrate, a dialysis machine, a product container, and a recirculation container. The dialysis machine is configured to receive purified water from the water purification unit and to mix the purified water with the at least one concentrate to form dialysis fluid. The product container is positioned and arranged to receive the dialysis fluid from the dialysis machine, and the recirculation container is configured to receive an end of the drain line and an end of the dialysis fluid return line. Further, the recirculation container enables dialysis fluid to be recirculated from the drain line, through the dialysis fluid return line, back to the dialysis machine and is configured to be positioned adjacent to a facility drain such that overflow dialysis fluid flows from the recirculation container into the facility drain.

公开(公告)号：US12151079B2

公开(公告)日：2024-11-26

申请号：US16598926

申请日：2019-10-10

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A.

Inventor： Roger L. Hungerford ,  Curt Matthew Allen

IPC: A61M5/14 ,  A61M5/168

Abstract: An infusion pump including an interface unit for receiving first data for a first infusion regimen for a medication, the first regimen including a first unit of measure in which the first regimen is executed and after receipt of the first data, second data for a second infusion regimen for the medication, the second regimen including a second unit of measure in which the second regimen is executed. The pump also includes a processor for comparing the first and second units of measure. In one embodiment, the pump includes a graphical user interface, and the processor identifies a difference between the first and second units of measure; generates, using the processor, a warning message; and displays the message on the graphical user interface. In another embodiment, the processor holds in abeyance initiation of the second infusion regimen in response to identifying the difference between the units of measure.