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公开(公告)号：US06846897B2
公开(公告)日：2005-01-25
申请号：US10847941
申请日：2004-05-18
CPC分类号： C07F7/081 , Y10S623/905 , Y10S623/907
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.
摘要翻译： 本文描述了光学透明，相对高折射率的聚合物组合物和眼科装置，例如眼内透镜，隐形眼镜和角膜嵌体。 优选的聚合物组合物通过一种或多种芳族基甲硅烷基单体的聚合或一种或多种芳族基甲硅烷基单体与一种或多种芳族或非芳族非甲硅烷氧基单体，疏水单体或亲水 单体。
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公开(公告)号：US06673886B2
公开(公告)日：2004-01-06
申请号：US09975441
申请日：2001-10-10
申请人： David P. Vanderbilt
发明人： David P. Vanderbilt
IPC分类号： C08F11802
CPC分类号： G02B1/043 , A61L27/16 , A61L2430/16 , C08F220/26 , C08L33/02 , C08L33/14
摘要： Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.
摘要翻译： 光学透明，高折射率水凝胶和由其制造的眼内透镜。 优选的水凝胶的折射率为1.45以上，水含量为约5〜30重量％。
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公开(公告)号：US5326506A
公开(公告)日：1994-07-05
申请号：US010373
申请日：1993-01-28
申请人： David P. Vanderbilt
发明人： David P. Vanderbilt
CPC分类号： A61F2/16 , A61F2/1616 , A61L27/16 , A61L27/52 , A61F2002/1681 , A61F2002/16905 , A61L2430/16
摘要： A method for making a composite intraocular lens having an optic portion and haptic portion. The method includes the steps of forming a core of a high refractive material suitable for use as an intraocular lens optic, swelling the core, placing a polymerizable material capable of forming an intraocular lens haptic about the core, and polymerizing the polymerizable material. The method further includes the step of machining the resulting composite rod in order to form a composite intraocular lens having an optic portion and a haptic portion.
摘要翻译： 一种制造具有光学部分和触觉部分的复合眼内透镜的方法。 该方法包括以下步骤：形成适于用作眼内透镜光学元件的高折射材料的芯，使芯体膨胀，将能够形成眼内透镜的可聚合材料放置在芯部周围触觉并聚合可聚合材料。 该方法还包括加工所得到的复合棒以形成具有光学部分和触觉部分的复合眼内透镜的步骤。
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4.发明授权
公开(公告)号：US5278201A
公开(公告)日：1994-01-11
申请号：US513782
申请日：1990-04-24
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61K9/00 , A61K9/22 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58
CPC分类号： A61K9/0024 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/0015 , A61L24/0026 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L26/0019 , A61L26/0066 , A61L26/0076 , A61L26/009 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61F2002/30062 , A61F2002/30583 , A61F2210/0004 , A61F2210/0085 , A61L2300/25 , A61L2300/252 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/604 , Y10S525/937
摘要： A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
摘要翻译： 提供可生物降解的聚合物用于为动物提供可注射的，原位成型的固体可生物降解植入物。 将聚合物以液体形式置于动物体内并固化以原位形成植入物。 形成所述植入物的热塑性体系包括以下步骤：将非反应性聚合物溶解在生物相容性溶剂中以形成液体，将液体置于动物体内，并允许溶剂消散以产生植入物。 一种替代的热固性体系包括将有效量的液体丙烯酸酯封端的，可生物降解的预聚物和固化剂混合在一起，将液体混合物置于动物体内并使预聚物固化以形成植入物。 两种系统通过在注射到体内之前向液体中添加有效水平的生物活性剂来提供可注射的，可固体的可生物降解的递送系统。
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公开(公告)号：US07988988B2
公开(公告)日：2011-08-02
申请号：US11283632
申请日：2005-11-21
CPC分类号： C08J7/047 , A61L27/34 , C08J2443/00 , G02B1/043 , C08L101/02
摘要： A biomedical device, such as a contact lens, has a surface linked to a polymer comprising boronic acid moieties. The boronic acid monomeric units may be derived from an ethylenically unsaturated monomer containing a boronic acid moiety, such as a vinylphenyl boronic acid or a (meth)acrylamido phenyl boronic acid. The boronic acid moieties may be complexed with mucin, especially epithelial mucin.
摘要翻译： 诸如隐形眼镜的生物医学装置具有与包含硼酸部分的聚合物连接的表面。 硼酸单体单元可以衍生自含有硼酸部分的乙烯性不饱和单体，例如乙烯基苯基硼酸或（甲基）丙烯酰胺基苯基硼酸。 硼酸部分可能与粘蛋白，特别是上皮粘蛋白复合。
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公开(公告)号：US20110144746A1
公开(公告)日：2011-06-16
申请号：US12917722
申请日：2010-11-02
申请人： David P. Vanderbilt
发明人： David P. Vanderbilt
IPC分类号： A61F2/16 , C08K5/3475
CPC分类号： A61F2/16 , A61F2/1613 , A61F2002/1681 , A61F2002/16965 , C07D249/20 , G02B1/043
摘要： An intraocular lens comprising: (a) monomeric units derived from at least one cationically polymerizable branched alkene monomer; (b) monomeric units derived from at least one cationically polymerizable monomer having a pendant benzocyclobutene group; and (c) a UV-absorbing benzotriazole component having the formula I.
摘要翻译： 一种眼内透镜，其包含：（a）衍生自至少一种阳离子可聚合支化烯烃单体的单体单元; （b）衍生自至少一种具有侧链苯并环丁烯基的阳离子聚合性单体的单体单元; 和（c）具有式I的UV吸收苯并三唑组分。
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公开(公告)号：US06657030B2
公开(公告)日：2003-12-02
申请号：US09975339
申请日：2001-10-10
申请人： David P. Vanderbilt
发明人： David P. Vanderbilt
IPC分类号： C08J2606
CPC分类号： G02B1/043 , A61L27/16 , A61L2430/16 , C08F220/26 , C08L33/02 , C08L33/14
摘要： Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.
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公开(公告)号：US06454802B1
公开(公告)日：2002-09-24
申请号：US09642966
申请日：2000-08-21
IPC分类号： A61F216
CPC分类号： A61L27/50 , A61F2/16 , A61F2002/009 , A61F2002/1699 , A61L2400/18
摘要： A surface treated intraocular lens implant for use in the replacement of a cataractous natural lens to prevent posteriror capsular opacification. The surface treated intraocular lens includes one or more proteins, polypeptides, polyamino acids or polyamines bound to the surface of the intraocular lens implant covalently, non-covalently or a combination thereof. The one or more proteins, polypeptides, polyamino acids or polyamines present on the surface of the intraocular lens implant serves to reduce or eliminate residual lens epithelial cell migration within the lens capsule. By preventing residual lens epithelial cell migration, posterior capsular opacification of the intraocular lens implant is thus reduced or eliminated.
摘要翻译： 一种表面处理的眼内晶状体植入物，用于替代白内障天然晶状体以防止后囊膜混浊。 表面处理的眼内透镜包括共价，非共价或其组合结合到眼内透镜植入体表面的一种或多种蛋白质，多肽，聚氨基酸或多胺。 存在于眼内透镜植入物的表面上的一种或多种蛋白质，多肽，聚氨基酸或多胺用于减少或消除晶状体囊内剩余的晶状体上皮细胞迁移。 通过防止残留的晶状体上皮细胞迁移，因此减少或消除了眼内透镜植入物的后囊膜混浊。
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公开(公告)号：US07780678B2
公开(公告)日：2010-08-24
申请号：US10640131
申请日：2003-08-13
申请人： David P. Vanderbilt , Li-Chun Tsou
发明人： David P. Vanderbilt , Li-Chun Tsou
IPC分类号： A61F9/00
CPC分类号： A61L31/14 , A61K9/0051
摘要： Methods for enhancing the lubricity of implant delivery devices are provided. The present methods of enhancing the lubricity of an intraocular lens inserter reduce the force required to express an intraocular lens therefrom. By reducing the force required to express an intraocular lens from an inserter, intraocular lens delivery is improved.
摘要翻译： 提供了用于增强植入物输送装置的润滑性的方法。 目前提高眼内透镜插入器的润滑性的方法减少了从其中表达眼内透镜所需的力。 通过减少从插入器表达眼内透镜所需的力，改善了眼内晶状体的输送。
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公开(公告)号：US20080151180A1
公开(公告)日：2008-06-26
申请号：US11872305
申请日：2007-10-15
IPC分类号： G02C7/04
CPC分类号： C08J7/04 , A61L12/14 , Y10T428/31504
摘要： A contact lens is coated with a first polymer, such as a boronic acid-containing copolymer, having affinity to mucin, and a second polymer. The second polymer improves initial comfort of the contact lens. During wear of the contact lens, the second polymer is removed from the contact lens, by blinking and/or tear fluids, and mucin complexes with the first polymer on the contact lens surface.
摘要翻译： 隐形眼镜涂覆有对粘蛋白具有亲和性的第一聚合物，例如含硼酸的共聚物和第二聚合物。 第二种聚合物提高了隐形眼镜的初始舒适度。 在隐形眼镜的磨损期间，通过在接触透镜表面上闪烁和/或撕裂流体和与第一聚合物的粘蛋白复合物从隐形眼镜去除第二聚合物。
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