知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

45 条记录 (耗时 0.036 秒)

    METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS
    1.
    发明申请
    METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS 有权
    用于超细处理细胞的方法和组合

    公开(公告)号：US20120143043A1

    公开(公告)日：2012-06-07

    申请号：US13361786

    申请日：2012-01-30

    申请人： Gholam A. Peyman

    发明人： Gholam A. Peyman

    IPC分类号： A61M37/00 ,  A61N2/06 ,  A61B5/055 ,  A61B8/00 ,  A61N5/00 ,  A61N2/02 ,  A61B6/00 ,  B82Y5/00

    CPC分类号： A61K41/0028 ,  A61K9/0009 ,  A61K41/0033 ,  A61K41/0052 ,  A61K49/0021 ,  A61K49/0084 ,  A61K49/227 ,  Y10S977/702 ,  Y10S977/703 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/911 ,  Y10S977/912

    摘要： A method and composition for hyperthermally diagnosing and monitoring treatment of cells with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue applies a heat source to kill cells without protein denaturation. The hyperthermia treatment may further comprise platelet-derived treatment. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. The temperature to which the target site is treated ranges from about 39° C. to about 58° C., and may last from about 5 seconds to about 30 minutes. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream to flow through the target site.

    摘要翻译： 用于光声和纳米颗粒的高温诊断和监测细胞治疗的方法和组合物。 测量目标组织内的热（温度）和光声声波产生。 使用激光和光声成像技术实现所需的温度。 组织的热疗治疗应用热源来杀死没有蛋白质变性的细胞。 热疗治疗可进一步包括血小板衍生治疗。 该方法引入在目标部位中在选定温度下释放的包封的染料，以指示达到阈值温度以对热处理组织。 靶位点处理的温度范围为约39℃至约58℃，并且可持续约5秒至约30分钟。 可以将包封染料的脂质体组合物的组合物引入血液流过目标部位。

    Molecules that home to various selected organs or tissues
    3.
    发明授权
    Molecules that home to various selected organs or tissues 失效
    归属于各种选定器官或组织的分子

    公开(公告)号：US06933281B2

    公开(公告)日：2005-08-23

    申请号：US10607595

    申请日：2003-06-27

    申请人： Erkki Ruoslahti ,  Renata Pasqualini

    发明人： Erkki Ruoslahti ,  Renata Pasqualini

    IPC分类号： A61K31/195 ,  A61K38/00 ,  A61K47/48 ,  C07K7/06 ,  C07K7/08 ,  A61K38/08 ,  G01N33/566

    CPC分类号： C07K7/06 ,  A61K31/195 ,  A61K38/00 ,  A61K47/6425 ,  C07K7/08 ,  Y10S977/808 ,  Y10S977/911 ,  Y10S977/912

    摘要： The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor bearing organs or tissues, including to pancreas bearing a pancreatic tumor or to lung bearing a lung tumor. The invention also provides conjugates, comprising an organ or tissue homing molecule linked to a moiety. Such a moiety can be, for example, a therapeutic agent or a detectable agent. In addition, the invention provides methods of using an organ homing molecule of the invention to identify a particular organ or tissue by contacting the organ or tissue with a molecule of the invention. The invention also provides methods to diagnose or treat a pathology of the lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut by administering to a subject having or suspected of having a pathology a molecule that homes to the selected organ or tissue. The invention further provides methods of identifying a target molecule in lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.

    摘要翻译： 本发明提供了选择性地归属于各种正常器官或组织，包括肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠道的分子; 并提供选择性地置于携带肿瘤的器官或组织，包括携带胰腺肿瘤的胰腺或携带肺肿瘤的肺的分子。 本发明还提供缀合物，其包含与部分连接的器官或组织归巢分子。 这样的部分可以是例如治疗剂或可检测剂。 此外，本发明提供使用本发明的器官归巢分子通过使器官或组织与本发明的分子接触来鉴定特定器官或组织的方法。 本发明还提供了通过对具有或怀疑具有病理学病理学的受试者进行诊断或治疗肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠道的病理学的方法 到选定的器官或组织。 本发明还提供鉴定肺，胰腺，皮肤，视网膜，前列腺，卵巢，淋巴结，肾上腺，肝脏或肠内的靶分子的方法。

    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
    7.
    发明申请
    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same 审中-公开
    用于治疗卵巢癌，聚（磷酸酯）组合物和用于其的生物可降解制品的方法

    公开(公告)号：US20040071774A1

    公开(公告)日：2004-04-15

    申请号：US10641301

    申请日：2003-08-14

    发明人： Wenbin Dang

    IPC分类号： A61K009/22

    CPC分类号： A61K9/1647 ,  A61K9/7007 ,  Y10S977/911 ,  Y10S977/912

    摘要： Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.

    摘要翻译： 描述了适用于腹膜内给药以治疗具有卵巢癌的哺乳动物受试者的可生物降解的聚合物组合物，其中所述聚合物组合物将抗肿瘤剂延长释放到受试者腹膜中。 与通过施用包含相同剂量的抗肿瘤剂的组合物而不使用生物可降解聚合物的组合物获得的中值存活率相比，主题组合物可将癌症的中值存活率提高至少约10％。 还描述了用于治疗卵巢癌的固体制品和方法。

    Purification of plasmid DNA
    9.
    发明授权
    Purification of plasmid DNA 失效
    纯化质粒DNA

    公开(公告)号：US06313285B1

    公开(公告)日：2001-11-06

    申请号：US09620849

    申请日：2000-07-21

    申请人： Michelle D. Butler ,  Darien L. Cohen ,  David Kahn ,  Marjorie E. Winkler

    发明人： Michelle D. Butler ,  Darien L. Cohen ,  David Kahn ,  Marjorie E. Winkler

    IPC分类号： C12N1510

    CPC分类号： C12N15/1017 ,  Y10S977/894 ,  Y10S977/898 ,  Y10S977/91 ,  Y10S977/912 ,  Y10S977/914 ,  Y10S977/924

    摘要： A process is described for purifying plasmid DNA from prokaryotic cells comprised thereof. This process comprises the steps of: (a) digesting the cells; (b) incubating the cells for about 4 to 24 hours to effect lysis and solubilization thereof, without effecting enzymatic digestion of RNA; (c) removing lysate contaminants from the cells to provide a plasmid DNA solution; (d) filtering the solution through a tangential flow filtration device to obtain a retentate containing the plasmid DNA; and (e) collecting the retentate.

    摘要翻译： 描述了从其组成的原核细胞中纯化质粒DNA的方法。 该方法包括以下步骤：（a）消化细胞; （b）将细胞孵育约4至24小时以进行裂解和溶解，而不影响RNA的酶促消化; （c）从细胞中除去裂解物污染物以提供质粒DNA溶液; （d）通过切向流过滤装置过滤溶液以获得含有质粒DNA的滞留物; 和（e）收集滞留物。