公开(公告)号：US20120000795A1

公开(公告)日：2012-01-05

申请号：US12827613

申请日：2010-06-30

Applicant: Sundara Ramaprabhu ,  Tessy Theres Baby

Inventor： Sundara Ramaprabhu ,  Tessy Theres Baby

IPC: G01N27/26 ,  H01F1/00

CPC classification number: G01N27/3278 ,  B82Y25/00 ,  H01F1/0054 ,  H01F1/0063 ,  Y10S977/747 ,  Y10S977/92 ,  Y10S977/957

Abstract: Disclosed are nanocomposite-based biosensors. The biosensors include an electrode, a nanocomposite over the surface of the electrode, the nanocomposite comprising a population of carbon nanotubes and a population of magnetic nanoparticles dispersed in the population of carbon nanotubes, wherein the magnetic nanoparticles comprise a ferromagnetic metal or compound thereof, and one or more biomolecules over the surface of the electrode, wherein the biomolecules are capable of undergoing a redox reaction with a target molecule. Also disclosed are nanocomposites, modified electrodes, kits, and methods for using the biosensors.

Abstract translation: 公开了基于纳米复合物的生物传感器。 生物传感器包括电极，电极表面上的纳米复合材料，纳米复合材料包含一组碳纳米管和分散在碳纳米管群体中的一群磁性纳米颗粒，其中磁性纳米颗粒包含铁磁金属或其化合物，以及 在电极表面上的一个或多个生物分子，其中生物分子能够与靶分子进行氧化还原反应。 还公开了纳米复合材料，改性电极，试剂盒和使用生物传感器的方法。

公开(公告)号：US08093174B2

公开(公告)日：2012-01-10

申请号：US12524057

申请日：2008-01-16

Applicant: Ryota Yuge ,  Masako Yudasaka ,  Sumio Iijima

Inventor： Ryota Yuge ,  Masako Yudasaka ,  Sumio Iijima

IPC: B01J21/18 ,  D01F9/12 ,  D01C5/00 ,  B32B9/00 ,  D02G3/00

CPC classification number: B01J21/185 ,  B01J23/10 ,  B01J23/42 ,  B01J23/74 ,  B01J37/0203 ,  B01J37/14 ,  B82Y30/00 ,  H01M4/926 ,  Y10S977/742 ,  Y10S977/743 ,  Y10S977/744 ,  Y10S977/745 ,  Y10S977/746 ,  Y10S977/747 ,  Y10S977/748 ,  Y10S977/749 ,  Y10S977/75 ,  Y10S977/751 ,  Y10S977/752 ,  Y10S977/753 ,  Y10S977/754 ,  Y10S977/842 ,  Y10S977/843 ,  Y10S977/844 ,  Y10S977/845 ,  Y10S977/846 ,  Y10S977/847 ,  Y10S977/848 ,  Y10T428/2918

Abstract: A carbon nanohorn (CNH) is oxidized to make an opening in the side of the CNH. A substance to be included, e.g., a metal, is introduced through the opening. The inclusion substance is moved to a tip part of the carbon nanohorn through heat treatment in vacuum or an inert gas. The CNH is further heat treated in an atmosphere containing oxygen in a low concentration to remove the carbon layer in the tip through catalysis of the inclusion substance. This exposes the inclusion substance. If the inclusion substance is a metal which is not moved to a tip part by the heat treatment in vacuum or an inert gas, the carbon part surrounding the fine catalyst particle is specifically burned by a heat treatment in an low oxygen concentration atmosphere, while utilizing the catalysis. Thus, the fine catalyst particle is fixed to the tip part of the CNH.

Abstract translation: 碳纳米角（CNH）被氧化以在CNH的侧面形成开口。 通过开口引入待包括的物质，例如金属。 通过在真空或惰性气体中的热处理将包合物移动到碳纳米角的尖端部分。 CNH在含有低浓度氧气的气氛中进一步热处理，以通过催化包涵物质除去尖端中的碳层。 这暴露了包含物质。 如果包含物质是通过真空或惰性气体中的热处理而不移动到尖端部分的金属，则在低氧浓度气氛中通过热处理将微细催化剂粒子周围的碳部分特别燃烧，同时利用 催化。 因此，细小的催化剂颗粒固定在CNH的末端部分。

公开(公告)号：US07709243B2

公开(公告)日：2010-05-04

申请号：US11056234

申请日：2005-02-14

Applicant: Young-jun Park ,  Jong-min Kim ,  Sung-kee Kang ,  Jung-woo Kim

Inventor： Young-jun Park ,  Jong-min Kim ,  Sung-kee Kang ,  Jung-woo Kim

IPC: C12M1/00 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/68

CPC classification number: C12Q1/6837 ,  B82Y5/00 ,  B82Y30/00 ,  G01N27/226 ,  G01N33/54373 ,  Y10S977/742 ,  Y10S977/745 ,  Y10S977/746 ,  Y10S977/747 ,  Y10S977/748

Abstract: The present invention is related to a biochip and a biomolecular detection system using the same. In particular, the biomolecular detection system is capable of detecting biological molecules (biomolecules) such as DNA or protein at a high speed. The biochip comprises a supporting structure, conductive materials aligned vertically on, and associated with, the supporting structure, and biomolecule probes operably linked to the conductive materials. The biomolecular detection system using the biochip may precisely detect biomolecules as well as the density of the biomolecules.

Abstract translation: 本发明涉及生物芯片和使用其的生物分子检测系统。 特别地，生物分子检测系统能够高速检测DNA或蛋白质等生物分子（生物分子）。 生物芯片包括支撑结构，垂直于支撑结构并与支撑结构相关联的导电材料以及可操作地连接到导电材料的生物分子探针。 使用生物芯片的生物分子检测系统可以精确地检测生物分子以及生物分子的密度。

公开(公告)号：US07641863B2

公开(公告)日：2010-01-05

申请号：US10383309

申请日：2003-03-06

Applicant: Mitchel J. Doktycz ,  Michael L. Simpson ,  Timothy E. McKnight ,  Anatoli V. Melechko ,  Douglas H. Lowndes ,  Michael A. Guillorn ,  Vladimir I. Merkulov

Inventor： Mitchel J. Doktycz ,  Michael L. Simpson ,  Timothy E. McKnight ,  Anatoli V. Melechko ,  Douglas H. Lowndes ,  Michael A. Guillorn ,  Vladimir I. Merkulov

IPC: B01D63/00

CPC classification number: B01D67/0072 ,  B01D67/0088 ,  B01D67/0093 ,  B01D69/02 ,  B01D69/141 ,  B01D71/021 ,  B01D2323/30 ,  B01D2325/10 ,  B01J23/755 ,  B01J35/0013 ,  B01J37/34 ,  B82Y30/00 ,  Y10S977/701 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/706 ,  Y10S977/745 ,  Y10S977/746 ,  Y10S977/747 ,  Y10S977/789 ,  Y10S977/906 ,  Y10S977/92 ,  Y10S977/962

Abstract: A nanoengineered membrane for controlling material transport (e.g., molecular transport) is disclosed. The membrane includes a substrate, a cover defining a material transport channel between the substrate and the cover, and a plurality of fibers positioned in the channel and connected to and extending away from a surface of the substrate. The fibers are aligned perpendicular to the surface of the substrate, and have a width of 100 nanometers or less. The diffusion limits for material transport are controlled by the separation of the fibers. In one embodiment, chemical derivatization of carbon fibers may be undertaken to further affect the diffusion limits or affect selective permeability or facilitated transport. For example, a coating can be applied to at least a portion of the fibers. In another embodiment, individually addressable carbon nanofibers can be integrated with the membrane to provide an electrical driving force for material transport.

Abstract translation: 公开了一种用于控制材料输送的纳米工程膜（例如分子传输）。 膜包括衬底，限定衬底和盖之间的材料传输通道的盖，以及定位在通道中并连接到衬底表面并远离衬底的表面的多个光纤。 纤维垂直于衬底的表面排列，并且具有100纳米或更小的宽度。 材料输送的扩散限制是通过纤维的分离来控制的。 在一个实施方案中，可以进行碳纤维的化学衍生化以进一步影响扩散极限或影响选择性渗透性或促进转运。 例如，可以对至少一部分纤维施加涂层。 在另一个实施方案中，单独可寻址的碳纳米纤维可以与膜结合以提供材料输送的电驱动力。

公开(公告)号：US06656712B1

公开(公告)日：2003-12-02

申请号：US09673668

申请日：2000-12-01

Applicant: Fabrice Balavoine ,  Charles Miokowski ,  Patrick Schultz ,  Cyrille Richard

Inventor： Fabrice Balavoine ,  Charles Miokowski ,  Patrick Schultz ,  Cyrille Richard

IPC: C12N1114

CPC classification number: C07D495/04 ,  B82Y30/00 ,  C07C233/40 ,  C07C235/20 ,  C07C2603/24 ,  C07C2603/54 ,  C07F1/005 ,  C07F15/045 ,  C30B7/00 ,  C30B29/58 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/551 ,  Y10S977/729 ,  Y10S977/742 ,  Y10S977/746 ,  Y10S977/747 ,  Y10S977/793 ,  Y10S977/842 ,  Y10S977/848 ,  Y10S977/894 ,  Y10S977/896 ,  Y10S977/898 ,  Y10S977/92

Abstract: Method for the attachment and/or crystallization of macromolecules, chemical reagents used in the said method, products obtained as well as applications of the said products in the field of materials and of structural biology, in particular as biosensors or as biomaterials. The said method comprises essentially the incubation, without stirring, for at least 15 minutes, of a biological macromolecule in solution with nanotubes of carbon closed at their ends, under suitable temperature and pH conditions.

Abstract translation: 用于大分子的附着和/或结晶的方法，所述方法中使用的化学试剂，获得的产物以及所述产品在材料和结构生物学领域的应用，特别是作为生物传感器或生物材料。所述方法 在适当的温度和pH条件下基本上包括在其末端封闭碳纳米管的情况下，不搅拌至少15分钟孵育溶液中的生物大分子。

公开(公告)号：US20030139711A1

公开(公告)日：2003-07-24

申请号：US10323386

申请日：2002-12-18

Applicant: The Procter & Gamble Company

Inventor： Donald Carroll Roe ,  Francis James Rourke ,  Scott Edward Osborne

IPC: A61F013/15

CPC classification number: A61L15/46 ,  A61L2300/434 ,  Y10S977/747

Abstract: An absorbent article, at least a portion of which comprises a skin care composition that comprises an enzyme inhibitor and is at least partially transferred from the article to the skin of a wearer of the article as a result of normal contact, wearer motion and/or body heat. The enzyme inhibitor is transferred to the skin with the skin care composition and is available at the skin/urine and skin/feces interfaces to inhibit enzymatic activity on the skin and to reduce or prevent the occurrence of inflammation. Repeated application of similar treated articles to the wearer's skin provides an available source with which the enzyme inhibitor transfers onto the skin continuously over time and accumulates to provide a proactive defense against harmful enzymes for the treatment and/or prevention of diaper dermatitis.

Abstract translation: 一种吸收制品，其至少一部分包括护肤组合物，其包含酶抑制剂，并且由于正常接触，穿着者运动和/或至少部分地将物品至少部分转移到物品的穿着者的皮肤 体温。 酶抑制剂用皮肤护理组合物转移到皮肤中，并且可以在皮肤/尿液和皮肤/粪便界面处获得以抑制对皮肤的酶活性并减少或防止发炎。 类似处理的物品重复施用于穿着者的皮肤提供了可用的来源，酶抑制剂随时间连续地转移到皮肤上并积聚以提供主动防御有害的酶以治疗和/或预防尿布性皮炎。

公开(公告)号：US08072008B2

公开(公告)日：2011-12-06

申请号：US11956002

申请日：2007-12-13

Applicant: Koichi Mukasa ,  Kazuhisa Sueoka ,  Seiji Takeda ,  Satoshi Hattori ,  Yoshiki Yamada ,  Makoto Sawamura ,  Hiroichi Ozaki ,  Atsushi Ishii ,  Motonori Nakamura ,  Hirotaka Hosoi

Inventor： Koichi Mukasa ,  Kazuhisa Sueoka ,  Seiji Takeda ,  Satoshi Hattori ,  Yoshiki Yamada ,  Makoto Sawamura ,  Hiroichi Ozaki ,  Atsushi Ishii ,  Motonori Nakamura ,  Hirotaka Hosoi

IPC: G01N27/403 ,  H01L23/48 ,  H01L23/52 ,  H01L23/40 ,  A61B5/00 ,  C12Q1/00

CPC classification number: H01L51/0512 ,  B82Y10/00 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L51/0048 ,  H01L2924/0002 ,  H01L2924/19107 ,  Y10S977/746 ,  Y10S977/747 ,  Y10S977/904 ,  Y10S977/92 ,  Y10S977/924 ,  Y10S977/957 ,  Y10S977/958 ,  Y10S977/959 ,  H01L2924/00

Abstract: A high-sensitivity field effect transistor using as a channel ultrafine fiber elements such as carbon nanotube, and a biosensor using it. The field effect transistor comprises a substrate, a source electrode and a drain electrode arranged on the substrate, a channel for electrically connecting the source electrode with the drain electrode, and a gate electrode causing polarization due to the movement of free electrons in the substrate. For example, the substrate has a support substrate consisting of semiconductor or metal, a first insulating film formed on a first surface of the support substrate, and a second insulating film formed on a second surface of the support substrate, the source electrode, the drain electrode, and the channel arranged on the first insulating film, the gate electrode disposed on the second insulating film.

Abstract translation: 使用碳纳米管作为通道超细纤维元件的高灵敏度场效应晶体管和使用它的生物传感器。 场效应晶体管包括衬底，设置在衬底上的源电极和漏电极，用于将源电极与漏电极电连接的沟道和由于衬底中的自由电子的移动引起极化的栅电极。 例如，基板具有由半导体或金属构成的支撑基板，形成在支撑基板的第一面上的第一绝缘膜和形成在支撑基板的第二表面上的第二绝缘膜，源电极，漏极 电极和布置在第一绝缘膜上的通道，栅电极设置在第二绝缘膜上。

公开(公告)号：US07928017B2

公开(公告)日：2011-04-19

申请号：US12076314

申请日：2008-03-17

Applicant: Jun-youn Kim ,  Joong S. Jeong ,  Eun-ju Bae

Inventor： Jun-youn Kim ,  Joong S. Jeong ,  Eun-ju Bae

IPC: H01L21/31

CPC classification number: H01L29/0665 ,  B82Y10/00 ,  H01L29/0673 ,  H01L29/161 ,  Y10S438/933 ,  Y10S977/747 ,  Y10S977/762 ,  Y10S977/938

Abstract: A method of forming a nanowire and a semiconductor device comprising the nanowire are provided. The method of forming a nanowire includes forming a patterned SiyGe1-y layer (where, y is a real number that satisfies 0≦y

Abstract translation: 提供了形成纳米线的方法和包括纳米线的半导体器件。 形成纳米线的方法包括在基底层上形成图案化的Si y Ga 1- y层（其中，y是满足0＆lt; nlE; y <1的实数），以及在第一氧化物内形成第一氧化物层和至少一个纳米线 通过对图案化的SiyGe1-y层进行第一氧化处理。

公开(公告)号：US07892553B2

公开(公告)日：2011-02-22

申请号：US11799367

申请日：2007-04-30

Applicant: Shyam S. Mohapatra ,  Arun Kumar

Inventor： Shyam S. Mohapatra ,  Arun Kumar

IPC: A61K39/395 ,  B82B3/00

CPC classification number: A61K9/5146 ,  A61K9/5161 ,  Y10S977/739 ,  Y10S977/746 ,  Y10S977/747 ,  Y10S977/90

Abstract: The present invention pertains to nanoparticles, comprising a metal and/or polymer core, with 7-alpha hydroxylase, or an enzymatically active fragment thereof, nicotinamide adenine dinucleotide (NADH) and antibodies, or antibody fragments, specific for low density lipoprotein (LDL), attached to the core. The invention also concerns methods for reducing LDL cholesterol in a human or animal subject by administering nanoparticles of the invention. In a preferred embodiment, both circulating LDL and plasma cholesterol levels are reduced in the subject.

Abstract translation: 本发明涉及包含具有7-α羟化酶或其酶活性片段，特异于低密度脂蛋白（LDL）的烟酰胺腺嘌呤二核苷酸（NADH）和抗体或抗体片段的金属和/或聚合物核心的纳米颗粒， ，附在核心。 本发明还涉及通过施用本发明的纳米颗粒来降低人或动物受试者中的LDL胆固醇的方法。 在优选的实施方案中，受试者中循环LDL和血浆胆固醇水平都降低。

公开(公告)号：US20100099551A1

公开(公告)日：2010-04-22

申请号：US12524057

申请日：2008-01-16

Applicant: Ryota Yuge ,  Masako Yodasaka ,  Sumio Iijima

Inventor： Ryota Yuge ,  Masako Yodasaka ,  Sumio Iijima

IPC: B01J31/02 ,  B01J21/18 ,  B01J23/00

CPC classification number: B01J21/185 ,  B01J23/10 ,  B01J23/42 ,  B01J23/74 ,  B01J37/0203 ,  B01J37/14 ,  B82Y30/00 ,  H01M4/926 ,  Y10S977/742 ,  Y10S977/743 ,  Y10S977/744 ,  Y10S977/745 ,  Y10S977/746 ,  Y10S977/747 ,  Y10S977/748 ,  Y10S977/749 ,  Y10S977/75 ,  Y10S977/751 ,  Y10S977/752 ,  Y10S977/753 ,  Y10S977/754 ,  Y10S977/842 ,  Y10S977/843 ,  Y10S977/844 ,  Y10S977/845 ,  Y10S977/846 ,  Y10S977/847 ,  Y10S977/848 ,  Y10T428/2918

Abstract: A carbon nanohorn (CNH) is oxidized to make an opening in the side of the CNH. A substance to be included, e.g., a metal, is introduced through the opening. The inclusion substance is moved to a tip part of the carbon nanohorn through heat treatment in vacuum or an inert gas. The CNH is further heat treated in an atmosphere containing oxygen in a low concentration to remove the carbon layer in the tip through catalysis of the inclusion substance. This exposes the inclusion substance. If the inclusion substance is a metal which is not moved to a tip part by the heat treatment in vacuum or an inert gas, the carbon part surrounding the fine catalyst particle is specifically burned by a heat treatment in an low oxygen concentration atmosphere, while utilizing the catalysis. Thus, the fine catalyst particle is fixed to the tip part of the CNH.

Abstract translation: 碳纳米角（CNH）被氧化以在CNH的侧面形成开口。 通过开口引入待包括的物质，例如金属。 通过在真空或惰性气体中的热处理将包合物移动到碳纳米角的尖端部分。 CNH在含有低浓度氧气的气氛中进一步热处理，以通过催化包涵物质除去尖端中的碳层。 这暴露了包含物质。 如果包含物质是通过真空或惰性气体中的热处理而不移动到尖端部分的金属，则在低氧浓度气氛中通过热处理将微细催化剂粒子周围的碳部分特别燃烧，同时利用 催化。 因此，细小的催化剂颗粒固定在CNH的末端部分。