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    Nucleotide and protein sequences of lats genes and methods based thereon
    1.
    发明授权
    Nucleotide and protein sequences of lats genes and methods based thereon 失效
    基因的核苷酸和蛋白质序列及其基础的方法

    公开(公告)号：US06559285B1

    公开(公告)日：2003-05-06

    申请号：US08939106

    申请日：1997-11-26

    申请人： Tian Xu ,  Wufan Tao ,  Weiyi Wang ,  Sheng Zhang ,  Wan Yu

    发明人： Tian Xu ,  Wufan Tao ,  Weiyi Wang ,  Sheng Zhang ,  Wan Yu

    IPC分类号： C12P2108

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  A61K48/00 ,  C07K14/43581 ,  C07K14/4703 ,  C07K2319/00 ,  C12N15/8206 ,  Y10S435/81 ,  Y10S435/925

    摘要： The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the lats protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of lats which comprise one or more domains of a lats protein. Antibodies to lats, its derivatives and analogs, are additionally provided. Methods of production of the lats proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. The invention also relates to recombinant plants and animals and methods of increasing the growth of edible plants and animals. In specific examples, isolated lats genes, from Drosophila, mouse, and human, and the sequences thereof, are provided.

    摘要翻译： 本发明涉及称为大肿瘤抑制因子（lats）的肿瘤抑制基因，以及鉴定肿瘤抑制基因的方法。 该方法提供了lat基因的核苷酸序列及其编码的蛋白质的氨基酸序列，以及衍生物（例如片段）及其类似物。 在一个具体的实施方案中，纬丝蛋白是人蛋白质。 本发明还涉及包含一个或多个纬丝蛋白结构域的纬丝的片段（及其衍生物和类似物）。 还提供了抗体，其衍生物和类似物的抗体。 还提供了通过重组方法生产纬丝蛋白，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 本发明还涉及重组植物和动物以及增加可食用植物和动物生长的方法。 在具体实例中，提供了来自果蝇，小鼠和人的分离的lat基因及其序列。

    Microbiological synthesis of proteinaceous material employing normally gaseous hydrocarbon substrate and the products thereof
    3.
    发明授权
    Microbiological synthesis of proteinaceous material employing normally gaseous hydrocarbon substrate and the products thereof 失效
    使用通常气态烃基质的蛋白质物质的微生物合成及其产物

    公开(公告)号：US4028182A

    公开(公告)日：1977-06-07

    申请号：US562085

    申请日：1975-03-26

    申请人： James E. Zajic ,  Bohumil Volesky

    发明人： James E. Zajic ,  Bohumil Volesky

    IPC分类号： C12N1/30 ,  C12B1/00

    CPC分类号： C12N1/30 ,  Y10S435/804 ,  Y10S435/874 ,  Y10S435/911 ,  Y10S435/925

    摘要： A new process for cultivating selected cultures involves initially removing broth at a first rate from a fermentation and replacing it with supporting medium, the replacement rate thereafter being increased to remove cultures of lower growth rate than the selected culture. A new process for the microbiological synthesis of protein-containing material by an aerobic fermentation in a supporting medium uses a normally gaseous hydrocarbon substrate selected from nethane, ethane, propane and butane and a protein-producing fungus of graphium species. It has not been known hitherto for such syntheses to be possible with a fungus. The said substrate may be natural gas.

    摘要翻译： 用于培养选定培养物的新方法包括首先从发酵中以第一速率去除培养液并用支持培养基代替，随后的替代率被增加以除去比所选培养物更低生长速率的培养物。 通过需氧发酵在支持培养基中微生物合成含蛋白质材料的新方法使用选自正丁烷，乙烷，丙烷和丁烷的常规气态烃底物和一种产生蛋白质的石墨物质的真菌。 迄今尚不知道这样的合成是可能的与真菌。 所述衬底可以是天然气。

    Production of cephalosporin c
    8.
    发明授权
    Production of cephalosporin c 失效
    生产CEPHALOSPORIN C

    公开(公告)号：US3825473A

    公开(公告)日：1974-07-23

    申请号：US27788172

    申请日：1972-08-04

    申请人： ALFA FARMACEUTICI SPA

    发明人： GARGIUOLO F

    IPC分类号： C07D501/02 ,  C12P35/06 ,  C12R1/745 ,  C12D9/22

    CPC分类号： C12P35/06 ,  Y10S435/813 ,  Y10S435/925

    摘要： CEPHALOSPORIN C, WHICH IS USEFUL AS A STARTING MATERIAL IN THE PREPARATION OF THE SEMI-SYNTHETIC CEPHALOSPORIN ANTIBIOTICS, IS PRODUCED BY THE AEROBIC CULTIVATION OF A NOVEL MICROORGANISM, CEPHALOSPORIUM SP. STRAIN F. 12 (ATCC 20339). THE CULTIVATION IS PERFORMED IN A NUTRIENT MEDIUM CONTAINING ASSIMILABLE SOURCES OF CARBON AND NITROGEN, ONE OR MORE INORGANIC SALTS, AND AN ORGANIC SOURCE OF SULFUR. HIGH YIELDS OF CEPHALOSPORIN C ARE OBTAINED, WITH REDUCED YIELDS OF THE UNDESIRABLE BY-PRODUCT CEPHALOSPORIN N, BY COMPARISON WITH PREVIOUSLY USED CEPHALOSPORIUM STRAINS.

    Method for producing cephalosporin c
    9.
    发明授权
    Method for producing cephalosporin c 失效
    生产CEPHALOSPORIN C的方法

    公开(公告)号：US3816257A

    公开(公告)日：1974-06-11

    申请号：US30686372

    申请日：1972-11-15

    申请人： TAKEDA CHEMICAL INDUSTRIES LTD

    发明人： YAMANO T ,  KANZAKI T ,  SUIDE H ,  TSUBAKI K

    IPC分类号： C12P35/06 ,  C12D9/04

    CPC分类号： C12P35/06 ,  Y10S435/925

    摘要： A method for producing cephalosporin C, which comprises culturing a microorganism belonging to a hitherto undiscovered species of the genus Cephalosporium so that cephalosporin C may be accumulated in the culture medium, then recovering so accumulated cephalosporin C from the culture broth. Thus, a new species was established by the present inventors and named as Cephalosporium polyaleurum.