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    Mutational profiles in HIV-1 protease and reverse transcriptase correlated with phenotypic drug resistance
    1.
    发明授权
    Mutational profiles in HIV-1 protease and reverse transcriptase correlated with phenotypic drug resistance 有权
    HIV-1蛋白酶和逆转录酶的突变特征与表型耐药性相关

    公开(公告)号：US07494768B1

    公开(公告)日：2009-02-24

    申请号：US09580491

    申请日：2000-05-30

    Applicant: Kurt Hertogs ,  Brendan Larder ,  Rudi Pauwels

    Inventor： Kurt Hertogs ,  Brendan Larder ,  Rudi Pauwels

    IPC: C12Q1/70 ,  C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/703 ,  Y10S435/911 ,  Y10S435/912

    Abstract: The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e., drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis.

    Abstract translation: 本发明提供与HIV药物的表型抗性相关的HIV-1逆转录酶和/或蛋白酶基因的新突变，突变组合或突变分布。 更具体地，本发明涉及HIV的目标群体的基因型表征的使用以及该信息随后与表型解释的相关性，以将病毒突变特征与耐药性相关联。 本发明还涉及在数据库，药物开发，即药物设计，药物修饰，治疗和治疗设计，临床管理和诊断分析中利用本发明的突变特征的方法。

    Gene markers for beef marbling and tenderness
    3.
    发明授权
    Gene markers for beef marbling and tenderness 失效
    牛肉大理石花纹和压痛的基因标记

    公开(公告)号：US06569629B1

    公开(公告)日：2003-05-27

    申请号：US09975327

    申请日：2001-10-11

    Applicant: Daral J. Jackwood ,  Francis Fluharty

    Inventor： Daral J. Jackwood ,  Francis Fluharty

    IPC: C12Q168

    CPC classification number: C12Q1/6888 ,  Y10S435/912

    Abstract: Methods and compositions are provided for objectively identifying: i) bovine animals having the genetic potential to produce beef that is marbled or tender, and ii) bovine carcasses whose beef is marbled or tender. The methods comprise extracting DNA from a sample obtained from a bovine animal or carcass, assaying for the presence of a DNA comprising a sequence, referred to hereinafter as a “genetic marker”, in the DNA sample. In one aspect, the genetic marker is a marker of marbling, and comprises the sequence set forth in SEQ ID NO. 1. In another aspect, the genetic marker is a marker of tenderness, and comprises the sequence set forth in SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 or combinations thereof. The compositions include primers that amplify markers of marbled or tender beef present in bovine animal or carcass genomes and hybridization probes to detect marbling or tenderness markers.

    Abstract translation: 提供方法和组合物用于客观地识别：i）具有遗传潜力的牛动物，以生产大理石或嫩的牛肉，以及ii）牛肉大理石或嫩的牛尸体。 所述方法包括从获自牛动物或屠体的样品中提取DNA，测定在DNA样品中存在包含序列（以下称为“遗传标记”）的DNA。 一方面，遗传标记是大理石花纹的标记，并且包含SEQ ID NO： 另一方面，遗传标记是压痛的标记，并且包含SEQ ID NO：1所示的序列。 2，SEQ ID NO： 3，SEQ ID NO： 4或其组合。 组合物包括扩增存在于牛动物或胴体基因组中的大理石或嫩牛肉的标记物的引物和用于检测大理石花纹或压痕标记物的杂交探针。

    SIGNAL ENHANCEMENT OF BISPECIFIC ANTIBODY-POLYMER PROBE FOR IMMUNOASSAY USE
    4.
    发明申请
    SIGNAL ENHANCEMENT OF BISPECIFIC ANTIBODY-POLYMER PROBE FOR IMMUNOASSAY USE 有权
    双功能抗体聚合物检测手段免疫功能的信号增强

    公开(公告)号：US20020031781A1

    公开(公告)日：2002-03-14

    申请号：US09380168

    申请日：1999-10-06

    Inventor： BAN-AN KHAW ,  JAGAT NARULA

    IPC: G01N033/53

    CPC classification number: A61K31/415 ,  A61K31/74 ,  A61K47/62 ,  A61K49/0002 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/31 ,  G01N33/53 ,  G01N33/532 ,  G01N33/54306 ,  G01N33/58 ,  G01N33/6887 ,  Y10S435/817 ,  Y10S435/912

    Abstract: An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a second antibody specific for a compound foreign to said patient sample, and subsequently reacting the patient sample with a polymer probe, wherein the polymer probe includes a compound recognized by the second antibody in the bispecific antibody complex and further includes at least two detectable signals; the bispecific antibody; and the polymer probe of the immunoassay method are disclosed.

    Abstract translation: 一种免疫测定方法，包括使来自患者的样品与双特异性抗体反应，其中所述双特异性抗体包括对待检测化合物特异性的一种抗体和对于所述患者样品异种化合物特异的第二抗体，随后使患者样品与 聚合物探针，其中所述聚合物探针包括在所述双特异性抗体复合物中被第二抗体识别的化合物，并且还包括至少两个可检测信号; 双特异性抗体; 并公开了免疫测定法的聚合物探针。

    Method of determining melanoma micrometastasis using tyrosinase
    5.
    发明授权
    Method of determining melanoma micrometastasis using tyrosinase 失效
    使用酪氨酸酶测定黑素瘤微转移的方法

    公开(公告)号：US6153388A

    公开(公告)日：2000-11-28

    申请号：US245822

    申请日：1999-02-05

    Applicant: Douglas S. Reintgen

    Inventor： Douglas S. Reintgen

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  Y10S435/912

    Abstract: A highly sensitive method to detect melanoma micrometastasis by examining lymph nodes for the presence of tyrosinase messenger RNA. In a preferred mode, this is accomplished using the combination of reverse transcription and double round polymerase chain reaction (RT-PCR). The amplified samples are examined on a 2% agarose gel and tyrosinase is seen as a 207 base pair fragment. The lymph nodes examined are determined using pre- and intra- operative node mapping.

    Abstract translation: 通过检查淋巴结存在酪氨酸酶信使RNA来检测黑素瘤微转移的高度灵敏的方法。 在优选的模式中，使用逆转录和双重循环聚合酶链反应（RT-PCR）的组合来实现。 扩增的样品在2％琼脂糖凝胶上检查，酪氨酸酶被看作207碱基对片段。 检查的淋巴结使用术前和术中的节点映射来确定。

    Production of lipase
    8.
    发明授权
    Production of lipase 失效
    生产脂肪

    公开(公告)号：US3634195A

    公开(公告)日：1972-01-11

    申请号：US3634195D

    申请日：1969-09-08

    Applicant: MILES LAB

    Inventor： MELACHOURIS NICHOLAS ,  CHARLES ROBERT LEMOYNE

    IPC: C12N9/20 ,  C12D13/06

    CPC classification number: C12N9/20 ,  Y10S435/912

    Abstract: A lipase enzyme which hydrolyzes glycerides of long-chain carboxylic acids in preference to those of short-chain carboxylic acids can be produced by growing under aerobic conditions a culture of a strain of Absidia in a medium containing appropriate nutrients and then recovering the enzyme therefrom. An especially useful strain is Absidia butleri.

    Abstract translation: 通过在需氧条件下，在含有适当营养物质的培养基中培养茜草属的培养物，然后从其中回收酶，可以产生优选长链羧酸甘油酯优于短链羧酸的脂肪酶。 一种特别有用的菌株是耻垢is虫（Absidia butleri）。

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