知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

57 条记录 (耗时 0.014 秒)

    Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    1.
    发明申请
    Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use 失效
    纯化的丙型肝炎病毒包膜蛋白用于诊断和治疗用途

    公开(公告)号：US20020182706A1

    公开(公告)日：2002-12-05

    申请号：US09973025

    申请日：2001-10-10

    申请人： Innogenetics NV

    发明人： Geert Maertens ,  Fons Bosman ,  Guy De Martynoff ,  Marie Ange Buyse

    IPC分类号： C12N007/02 ,  C12P021/02

    CPC分类号： C07K16/109 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/5256 ,  C07K14/005 ,  C07K2317/34 ,  C12N2710/24143 ,  C12N2770/24222 ,  C12N2770/24234 ,  C12N2770/24243 ,  Y10S435/803 ,  Y10S435/81 ,  Y10S435/915 ,  Y10S435/975

    摘要： The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.

    摘要翻译： 本发明涉及一种纯化选自E1和/或E1 / E2的重组HCV单个或特异性寡聚包膜蛋白的方法，其特征在于在裂解转化的宿主细胞以分离重组表达的蛋白质二硫键切割或 还原步骤用二硫键切割剂进行。 本发明还涉及通过这种方法分离的组合物。 本发明还涉及这些组合物的诊断和治疗应用。 此外，本发明涉及HCV E1蛋白和肽用于预测和监测HCV治疗的临床有效性和/或临床结果的用途。

    Bioactive substance having antitumor activity, producing strain, and production thereof
    2.
    发明授权
    Bioactive substance having antitumor activity, producing strain, and production thereof 失效
    具有抗肿瘤活性，生产菌株及其生产的生物活性物质

    公开(公告)号：US5965430A

    公开(公告)日：1999-10-12

    申请号：US923691

    申请日：1997-09-04

    申请人： Hidenao Takazawa

    发明人： Hidenao Takazawa

    IPC分类号： C12P21/00 ,  A61K38/00 ,  A61P35/00 ,  C07K14/37 ,  C07K14/38 ,  C07K14/41 ,  C12N1/14 ,  C12R1/67

    CPC分类号： C12R1/67 ,  C07K14/38 ,  A61K38/00 ,  Y10S435/915

    摘要： Asn-linked glycoprotein having antitumor activity, with molecular weight of 32-84 kDa, its producing strain, production and use, adsorbs to Con. A. The process for its production comprises culturing a microorganism belonging to genus Aspergillus and isolating from the culture medium Asn-linked glycoprotein having a molecular weight of 32-84 kDa which adsorbs to Con. A, or a mixture thereof. The substance having antitumor activity is effective for treatment of solid tumors, ascites tumors, multiple cytoma and oval tumors and for the suppression of tumors.

    摘要翻译： 具有抗肿瘤活性的Asn连接的糖蛋白，分子量为32-84kDa，其生产菌株，生产和使用，吸附于Con。 A.其生产方法包括培养属于曲霉属的微生物，并从吸附于Con的分子量为32-84kDa的培养基Asn连接的糖蛋白分离。 A或其混合物。 具有抗肿瘤活性的物质对于治疗实体瘤，腹水肿瘤，多发性细胞瘤和卵圆形肿瘤以及抑制肿瘤是有效的。

    Process for preparing hydroxycyclopentenone derivatives using microorganisms
    4.
    发明授权
    Process for preparing hydroxycyclopentenone derivatives using microorganisms 失效
    使用微生物制备羟基环戊烯酮衍生物的方法

    公开(公告)号：US3892630A

    公开(公告)日：1975-07-01

    申请号：US47320874

    申请日：1974-05-24

    申请人： TEIJIN LTD

    发明人： KUROZUMI SEIZI ,  TORU TAKASHI ,  ISHIMOTO SACHIO

    IPC分类号： C07C405/00 ,  C12P7/42 ,  C12P7/62 ,  C07B29/02

    CPC分类号： C12R1/66 ,  C07C405/00 ,  C12P7/42 ,  C12P7/62 ,  Y10S435/913 ,  Y10S435/915 ,  Y10S435/917

    摘要： A process for preparing hydroxycyclopentenone derivatives, which comprises cultivating a microorganism belonging to the genus Aspergillus in a medium containing a cyclopentenone derivative expressed by the formula (1)

    WHEREIN R is a hydrogen atom or a lower alkyl group, and m is an integer of 1 to 6, TO FORM IN SAID MEDIUM A HYDROXYCYCLOPENTENONE DERIVATIVE EXPRESSED BY THE FORMULA (2)

    WHEREIN R is the same as defined above, and n is equal to m or, (m - 2) when m is from 3 to 6, AND THEN RECOVERING THE HYDROXYCYCLOPENTENONE DERIVATIVE.

    摘要翻译： 一种制备羟基环戊烯酮衍生物的方法，其包括在含有由式（1）表示的环戊烯酮衍生物的培养基中培养属于曲霉属的微生物，其中R为氢原子或低级烷基，m为整数1 至6，表示公式中表达的羟基环戊烯酮衍生物（2）其中R与上述定义相同，当m为3至6时，n等于m或（m-2），然后 恢复羟基胆碱衍生物。