公开(公告)号：US5616496A

公开(公告)日：1997-04-01

申请号：US470640

申请日：1995-06-06

Applicant: John W. Frost ,  Karen M. Draths

Inventor： John W. Frost ,  Karen M. Draths

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/52 ,  C12P7/44 ,  C12R1/19 ,  C12N1/20

CPC classification number: C12N9/0069 ,  C12N15/52 ,  C12N9/1022 ,  C12N9/88 ,  C12P7/44 ,  C12Y113/11001 ,  Y10S435/849 ,  Y10S435/852

Abstract: A heterologous cell transformant is provided that biocatalytically converts a carbon source to catechol and cis, cis muconic acid. The cell transformant expresses heterologous genes encoding the enzymes 3-dehydroshikimate dehydratase, protocatechuate decarboxylase, and catechol 1,2-dioxygenase.

Abstract translation: 提供了异源细胞转化体，其将碳源生物催化转化为儿茶酚和顺式，顺式粘康酸。 细胞转化体表达编码3-脱氢莽草酸脱水酶，原儿茶酸脱羧酶和邻苯二酚1,2-双加氧酶的异源基因。

公开(公告)号：US5215919A

公开(公告)日：1993-06-01

申请号：US836844

申请日：1992-02-19

Applicant: Hiroyuki Miya ,  Mitsuru Kawada ,  Yoshio Sugiyama

Inventor： Hiroyuki Miya ,  Mitsuru Kawada ,  Yoshio Sugiyama

IPC: C12P7/62 ,  C12P41/00

CPC classification number: C12P7/62 ,  C12P41/00 ,  Y10S435/832 ,  Y10S435/849 ,  Y10S435/852 ,  Y10S435/873 ,  Y10S435/879 ,  Y10S435/88

Abstract: A (1R,2S)-2-hydroxycycloalkanecarboxylic acid ester is efficiently and selectively produced by microbial asymmetric reduction of a 2-oxocycloalkanecarboxylic acid ester with a bacterial strain or its processed material.

公开(公告)号：US5000966A

公开(公告)日：1991-03-19

申请号：US282044

申请日：1988-12-09

Applicant: Yasuhiro Sumino ,  Shigeya Kakimoto ,  Shun-ichi Akiyama

Inventor： Yasuhiro Sumino ,  Shigeya Kakimoto ,  Shun-ichi Akiyama

IPC: C12N9/78 ,  C12H1/00 ,  C12H1/14 ,  C12H1/15

CPC classification number: C12H1/003 ,  Y10S435/822 ,  Y10S435/824 ,  Y10S435/829 ,  Y10S435/83 ,  Y10S435/85 ,  Y10S435/852 ,  Y10S435/911 ,  Y10S435/921

Abstract: Ethyl carbamate in an alcoholic liquor is decomposed by contacting the alcoholic liquor with a culture broth or processed matter thereof obtained from a microorganism which belongs to the genus Gluconobacter, Flavobacterium, Arthrobacter, Achromobacter, Alcaligenes, Pseudomonas, Klebsiella, Rhodotorula, Rhodosporidium, Trichosporon or Candida, and is capable of decomposing ethyl carbamate. The alcoholic liquor is improved in quality, and has a low ethyl carbamate content.

公开(公告)号：US4904589A

公开(公告)日：1990-02-27

申请号：US247365

申请日：1988-09-21

Applicant: Haruyo Sato ,  Shinzo Imamura

Inventor： Haruyo Sato ,  Shinzo Imamura

IPC: C12P41/00 ,  C12R1/22 ,  C12R1/645

CPC classification number: C12P41/001 ,  Y10S435/822 ,  Y10S435/852 ,  Y10S435/877

Abstract: It is possible to efficiently obtain D-(31)-tartaric acid in high yield and to supply DL-tartaric acid of high concentration to the culture medium by cultivating a microorganism which belongs to the genus Pseudomonas, Cryptococcus, Tricosporon or Klebsiella and has an ability to assimilate L-(+)-tartaric acid and does not assimilate substantially D-(-)-tartaric acid in a culture medium containing DL-tartaric acid.

公开(公告)号：US4755381A

公开(公告)日：1988-07-05

申请号：US844973

申请日：1986-03-27

Applicant: Stanley J. Cryz

Inventor： Stanley J. Cryz

IPC: A61K39/02 ,  A61K39/108 ,  C08B37/00 ,  A61K31/715

CPC classification number: C08B37/00 ,  A61K39/0266 ,  Y10S435/852

Abstract: The present invention relates to immunogenic preparations of Klebsiella species serotype-specific capsular polysaccharides. The invention involves the treatment of Klebsiella capsular polysaccharides in dilute sodium hydroxide to detoxify co-purified toxic lipopolysaccharides and to yield immunogenic vaccine preparations safe for parenteral administration to humans. The polyvalent vaccines prepared by use of the above vaccine are effective at providing protection against infections caused by Klebsiella species bacilli.

Abstract translation: 本发明涉及克雷伯氏菌属血清型特异性荚膜多糖的免疫原性制剂。 本发明涉及在稀氢氧化钠中处理克雷伯氏菌荚膜多糖以解毒共同纯化的毒性多糖，并产生对人肠胃外给药安全的免疫原性疫苗制剂。 使用上述疫苗制备的多价疫苗对提供针对克雷伯杆菌属杆菌感染的保护是有效的。

公开(公告)号：US4606919A

公开(公告)日：1986-08-19

申请号：US772130

申请日：1985-08-30

Applicant: Llubinko Stojkovic ,  Rodmila Pavic ,  Vera Spasojevic

Inventor： Llubinko Stojkovic ,  Rodmila Pavic ,  Vera Spasojevic

IPC: A61K39/02 ,  A61K39/09 ,  A61K39/108 ,  A61K39/116 ,  C12N1/00 ,  C12N5/00

CPC classification number: A61K39/0266 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/092 ,  A61K2039/55505 ,  A61K2039/70 ,  Y10S435/849 ,  Y10S435/852 ,  Y10S435/873 ,  Y10S435/885

Abstract: A vaccine for curative and prophylactic treatment of urinary tract infections in humans. The vaccine contains inactivated bacteria which originate from the cultures of 8 to 14 uropathogenic bacteria strains isolated from the urine of a person suffering from a urinary tract infection and aluminum phosphate in an amount of 1.5-10 mg of AlPO.sub.4 per ml of solution. Such bacteria are of the species E. coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus morganii and Streptococcus faecolis.

Abstract translation: 一种治疗和预防性治疗人类尿路感染的疫苗。 该疫苗含有灭活的细菌，其来源于从患有尿路感染的人的尿液中分离出的8至14个尿毒性致病菌菌株的培养物，其量为每毫升溶液1.5-10mg的AlPO 4。 这种细菌是大肠杆菌，肺炎克雷伯菌，奇异变形杆菌，变形杆菌和猪链球菌。

公开(公告)号：US4492755A

公开(公告)日：1985-01-08

申请号：US393844

申请日：1982-06-30

Applicant: Robert O. Horwath ,  William J. Colonna

Inventor： Robert O. Horwath ,  William J. Colonna

IPC: C12N9/90 ,  C12P19/24 ,  C12N15/00 ,  C12R1/19 ,  C12R1/22 ,  C12R1/25

CPC classification number: C12P19/24 ,  C12N9/90 ,  Y10S435/849 ,  Y10S435/852 ,  Y10S435/857

Abstract: Process for preparing L-fructose from L-mannose by contacting L-mannose with L-mannose isomerase produced by a mutant microorganism selected from the group consisting of the genera Escherichia, Lactobacillus, and Klebsiella cultivated in the absence of an inducing sugar.

Abstract translation: 通过将L-甘露糖与由不存在诱导糖培养的埃希氏杆菌属，乳杆菌属和克雷伯氏菌属的突变体微生物产生的L-甘露糖异构酶接触，从L-甘露糖制备L-果糖的方法。

公开(公告)号：US4247639A

公开(公告)日：1981-01-27

申请号：US74282

申请日：1979-09-11

Applicant: Kenneth S. Kang ,  George T. Veeder, III

Inventor： Kenneth S. Kang ,  George T. Veeder, III

IPC: C04B24/38 ,  C09D7/00 ,  C12P19/04

CPC classification number: C08B37/006 ,  C04B24/38 ,  C09D7/002 ,  C12P19/04 ,  C08L5/00 ,  Y10S435/852

Abstract: A high-viscosity heteropolysaccharide composed of 33% mannose, 29% glucose, 21% galactose and 17% glucuronic acid, and containing 5.7% acetyl and 4.9% pyruvate.

Abstract translation: 由33％甘露糖，29％葡萄糖，21％半乳糖和17％葡萄糖醛酸组成的含有5.7％乙酰基和4.9％丙酮酸的高粘度杂多糖。

公开(公告)号：US4225672A

公开(公告)日：1980-09-30

申请号：US15681

申请日：1979-02-27

Applicant: Leo M. Hall

Inventor： Leo M. Hall

IPC: C07H3/06 ,  C12N9/10 ,  C12P19/44

CPC classification number: C12N9/1074 ,  C07H3/06 ,  C12P19/44 ,  Y10S435/832 ,  Y10S435/837 ,  Y10S435/852

Abstract: Disclosed herein is a method for producing maltooligosaccharide glycosides in substantially pure form which includes the steps of incubating a glucosyl donor and a glucosyl acceptor in the presence of a glucanotransferase enzyme under transglycosylating conditions and separating the maltooligosaccharide glycoside from the reaction mixture.

Abstract translation: 本文公开了一种以纯粹形式生产麦芽低聚糖苷的方法，其包括在转糖酶条件下在葡聚糖转移酶存在下温育葡糖基供体和葡糖基受体并从反应混合物中分离麦芽低聚糖苷的步骤。

公开(公告)号：US4067776A

公开(公告)日：1978-01-10

申请号：US635270

申请日：1975-11-25

Applicant: Waheed N. Khan

Inventor： Waheed N. Khan

IPC: C12Q1/04 ,  G01N33/579 ,  C12K1/04

CPC classification number: G01N33/579 ,  C12Q1/04 ,  Y10S435/852 ,  Y10S435/947

Abstract: A method for rapid bedside diagnostic differentiation between aseptic meningitis and Gram-negative bacterial meningitis is carried out in a positive control vessel, a negative control vessel and a test vessel, wherein each vessel contains an equal amount of lyophilized limulus lysate and the positive control vessel also contains an amount of lyophilized Gram-negative bacterial endotoxin.

Abstract translation: 在阳性对照容器，阴性对照容器和试验容器中进行无菌性脑膜炎与革兰氏阴性细菌性脑膜炎之间的快速床旁诊断分化的方法，其中每个容器含有等量的冻干鲎裂解物和阳性对照容器 还含有一定量的冻干革兰氏阴性细菌内毒素。