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    Device and method for cytology slide preparation
    5.
    发明申请
    Device and method for cytology slide preparation 有权
    细胞学幻灯片准备的装置和方法

    公开(公告)号：US20020039796A1

    公开(公告)日：2002-04-04

    申请号：US09826327

    申请日：2001-04-04

    Inventor： Gerson Botacini das Dores ,  Iwona Mielzynska-Lohnas ,  Eliane Taromaru ,  William J. Payne ,  Joseph P. Slattery ,  James G. Lazar

    IPC: G01N001/28

    CPC classification number: G01N33/54386 ,  Y10S435/921 ,  Y10S435/922 ,  Y10S435/923 ,  Y10S435/924 ,  Y10S435/962 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S436/81 ,  Y10T436/25 ,  Y10T436/25375

    Abstract: This invention provides a novel device and method for preparing cytology slides. The device comprises a book-like form including an absorbent material and filter attached to the inside surface of a front cover and a cytology slide removeably attached to an inside surface of a back cover. A sample is removed from the body of a patient, placed in a liquid-based solution, and then on the filter. When the book-like form is closed, the sample is effectively transferred to the slide. The device can be modified so that a plurality of slides are prepared at the same time.

    Abstract translation: 本发明提供了一种制备细胞学幻灯片的新型装置和方法。 该装置包括书本形式，其包括附接到前盖的内表面的吸收材料和过滤器以及可移除地附接到后盖的内表面的细胞学滑片。 将样品从患者体内取出，置于液体溶液中，然后放在过滤器上。 当书本形式关闭时，样本被有效地转移到幻灯片。 该装置可以被修改，以便同时准备多个幻灯片。

    Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same
    6.
    发明授权
    Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same 失效
    光学活性的1-苯基-2-取代的丙烷衍生物及其制备方法

    公开(公告)号：US06248573B1

    公开(公告)日：2001-06-19

    申请号：US09208842

    申请日：1998-12-10

    Applicant: Michio Ito ,  Noritsugu Yamasaki ,  Yoshinori Kobayashi ,  Kiyoshi Ikura

    Inventor： Michio Ito ,  Noritsugu Yamasaki ,  Yoshinori Kobayashi ,  Kiyoshi Ikura

    IPC: C12P722

    CPC classification number: C07C217/60 ,  C07C39/11 ,  C07C43/23 ,  C07C213/02 ,  C07C213/08 ,  C07C309/66 ,  C07C309/73 ,  C12P7/22 ,  C12P17/06 ,  Y02P20/55 ,  Y10S435/822 ,  Y10S435/832 ,  Y10S435/874 ,  Y10S435/911 ,  Y10S435/921 ,  Y10S435/93 ,  Y10S435/938

    Abstract: An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) wherein R1 and R2 represent a lower alkyl group, etc., or R1 and R2 may form together an alkylene group, etc.; R3, R4 and R5 represent a hydrogen atom, etc.; and X represents a hydroxyl group which may be protected with a protective group, or a halogen atom etc., can readily be produced (i) by permitting a microorganism belonging to the genus Torulaspora, the genus Candida, the genus Pichia or the like to act on a phenylacetone derivative and asymmetrically reducing the compound, or (ii) by sterically inverting an (R)-enantiomer. (R,R)-1-phenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (I). The ethanol derivative is useful as an anti-obesity agent and the like.

    Abstract translation: 式（I）所示的（S）-1-苯基-2-取代的丙烷衍生物，其中R1和R2表示低级烷基等，或者R1和R2可以一起形成亚烷基等; R3，R4和R5代表氢原子等; X表示可以被保护基或卤素原子等保护的羟基，可容易地制备（i）通过使属于弧菌属，假丝酵母​​属，毕赤酵母属等的微生物， 作用于苯基丙酮衍生物并不对称地还原化合物，或（ii）通过空间反转（R） - 对映异构体。 （I）化合物可以容易地获得具有高光学纯度的（R，R）-1-苯基-2 - [（2-苯基-1-甲基乙基）氨基]乙醇衍生物。 乙醇衍生物可用作抗肥胖剂等。

    Process for the enzymatic separation of enantiomers of rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic acid and of rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic esters
    9.
    发明授权
    Process for the enzymatic separation of enantiomers of rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic acid and of rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic esters 失效
    使用来自念珠菌的脂肪酶分离外消旋-2-氧杂环己烷-2,2.0.0,3H庚烷-7-羧酸酯的方法

    公开(公告)号：US5861304A

    公开(公告)日：1999-01-19

    申请号：US932933

    申请日：1997-09-17

    Applicant: Wolfgang Holla ,  Gerhard Beck

    Inventor： Wolfgang Holla ,  Gerhard Beck

    IPC: C07C69/757 ,  C12P15/00 ,  C12P41/00 ,  C12R1/07 ,  C12R1/38 ,  C12R1/66 ,  C12R1/72 ,  C12R1/785 ,  C12R1/845

    CPC classification number: C12P41/005 ,  C12P15/00 ,  Y10S435/921

    Abstract: Process for the resolution of rac-2-oxotricyclo�2.2.1.0.sup.3,5 !heptane-7-carboxylic acid esters using lipase from candida.Compounds of the formula I ##STR1## in which R.sup.1 has the meanings mentioned, may be obtained in isomerically pure form from enantiomer mixtures or racemic mixtures by reacting the compound of the formula I in the presence of a lipase or esterase from porcine liver, porcine pancreas, bovine pancreas or from microorganisms such as Candida, Pseudomonas, Mucor, Rhizopus and Aspergillus, or proteases from Bacillus in the presence of water and, if desired, a cosolvent and separating from one another the esters and acids present in the solution obtained.

    Abstract translation: 使用来自念珠菌的脂肪酶拆分外消旋-2-氧代三环[2.2.1.03,5]庚烷-7-羧酸酯的方法。 通过在来自猪的脂肪酶或酯酶的存在下使式I化合物与对映体混合物或外消旋混合物以异构体纯的形式获得其中R 1具有所述含义的式I的化合物（I） 肝，猪胰腺，牛胰腺或来自诸如假丝酵母属，假单胞菌属，毛霉属，根霉属和曲霉属的微生物或来自芽孢杆菌的蛋白酶，并且如果需要，共溶剂并且彼此分离存在于 溶液得到。

    Kit containing d-arabinitol dehydrogenase and NAD+ for determining d-arabinitol
    10.
    发明授权
    Kit containing d-arabinitol dehydrogenase and NAD+ for determining d-arabinitol 失效
    含有D-阿拉伯糖醇脱氢酶和NAD +的试剂盒用于测定D-阿拉伯糖醇

    公开(公告)号：US5766874A

    公开(公告)日：1998-06-16

    申请号：US479069

    申请日：1995-06-07

    Applicant: Charles Garrett Miyada ,  Arthur C. Switchenko ,  Melanie W. Quong ,  Man-Ying Laurie Wong

    Inventor： Charles Garrett Miyada ,  Arthur C. Switchenko ,  Melanie W. Quong ,  Man-Ying Laurie Wong

    IPC: C12N9/02 ,  C12N9/04 ,  C12N15/02 ,  C12P19/02 ,  C12P21/08 ,  C12Q1/04 ,  C12Q1/32 ,  C12R1/72 ,  C12R1/74 ,  C12R1/91 ,  G01N33/53 ,  G01N33/569 ,  G01N33/573 ,  G01N33/577 ,  C12N1/16

    CPC classification number: C12N9/0006 ,  C12P19/02 ,  Y10S435/81 ,  Y10S435/921 ,  Y10S435/924

    Abstract: A D-arabinitol dehydrogenase enzyme is prepared that is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. The enzyme is preferably obtained from Candida tropicalis ATCC 750 or Candida shehatae. The enzyme may also be obtained by recombinant DNA technology. Monoclonal antibodies are produced against the enzyme and can be used to identify the enzyme. The enzyme is used for detecting the presence of Candida in a host such as detecting Candida infection in a patient by determining the presence of D-arabinitol in a sample. The oxidation of D-arabinitol by nicotinamide adenine dinucleotide (NAD.sup.+) is catalyzed by the enzyme and the amount of NADH produced in a given time is determined. Also prepared is a composition containing the enzyme and NAD.sup.+ and a kit containing a packaged combination of the enzyme and NAD.sup.+.

    Abstract translation: 制备能够催化D-阿拉伯糖醇氧化并且基本上不能催化D-甘露糖醇的氧化并且基本上不含能够氧化D-甘露糖醇的其它酶的D-阿拉伯糖醇脱氢酶。 该酶优选获自热带假丝酵母ATCC 750或念珠菌（念珠菌）。 该酶也可以通过重组DNA技术获得。 针对酶产生单克隆抗体，可用于鉴定酶。 该酶用于通过测定样品中D-阿拉伯糖醇的存在来检测宿主中假丝酵母的存在，例如检测患者中的念珠菌感染。 由烟酰胺腺嘌呤二核苷酸（NAD +）氧化D-阿拉伯糖醇由酶催化，并确定在给定时间内产生的NADH的量。 还制备了含有酶和NAD +的组合物和含有酶和NAD +的包装组合的试剂盒。

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