Method and device for simultaneous independent motion measurement of multiple probes in atomic force microscope

    公开(公告)号:US11892471B2

    公开(公告)日:2024-02-06

    申请号:US17757328

    申请日:2021-05-08

    IPC分类号: G01Q20/02 G01Q60/38

    CPC分类号: G01Q20/02 G01Q60/38

    摘要: A device capable of simultaneous independent motion measurement of multiple probes in an atomic force microscope includes at least two cantilever arms arranged in parallel. The end of each cantilever arm is provided with a needle tip. The surface of each cantilever arm is provided with a grating structure with a periodic distribution rule for reflecting laser irradiated on the grating structure and receiving the laser through reflected light detectors. The discrimination and motion measurement includes the steps of irradiating the measurement laser of different wavelengths on the back surfaces of multiple probes through the same light path at the same time, adopting the grating structures of different feature sizes as physical labels of the multiple probes and reflecting high-order reflected light of the laser of different wavelengths by the grating structures at different angles to separate the light path.

    BIO-MICROELECTROMECHANICAL SYSTEM TRANSDUCER AND ASSOCIATED METHODS

    公开(公告)号:US20180095073A1

    公开(公告)日:2018-04-05

    申请号:US15594697

    申请日:2017-05-15

    发明人: James Hickman

    摘要: The invention discloses a bio-MEMS transducer comprising a cultured myotube and a piezoelectric microcantilever having the myotube attached thereto along a lengthwise extent of said microcantilever. The transducer may include an input/output processor operably connected with said piezoelectric microcantilever to process electrical signals received therefrom and to send electrical signals thereto. The invention may operate as a biosensor wherein the attached myotube contracts on contact with a sensed agent, the myotube contraction deflecting the microcantilever to generate a piezoelectric signal therefrom. The invention may also be used as a biosensor for quantitating physiologic response to an agent by measuring deflection of the cantilever caused by myotube contraction elicited by contact with the agent; and correlating the measurement to effectiveness of the sensed agent in causing a myotube physiologic response. The bio-transducer is a bioactuator when an applied electrical signal causes the piezoelectric microcantilever to deflect, thereby actuating the attached myotube.