公开(公告)号：US20230314435A1

公开(公告)日：2023-10-05

申请号：US18053399

申请日：2022-11-08

申请人： Capital Medical University

发明人： Lei LIU ,  Fangyan GONG

IPC分类号： G01N33/573

CPC分类号： G01N33/573 ,  G01N2333/912 ,  G01N2440/14 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/168

摘要： An application of a marker of a calcium-overload-mediated neuronal death in a preparation of a drug for treating multiple aging-related neurodegenerative diseases and in a disease testing method is provided. The aging-related neurodegenerative diseases include an Alzheimer's disease, a Parkinson's disease, amyotrophic lateral sclerosis, or glaucoma. The marker of the calcium-overload-mediated neuronal death and the application thereof, used in the present invention, are therapeutically effective for treating the Alzheimer's disease, the Parkinson's disease, the amyotrophic lateral sclerosis, and the glaucoma. Moreover, calcium overload and TLK2 hyperphosphorylation may be used as new molecular markers for predicting a disease occurrence progress or testing a therapeutic effect.

公开(公告)号：US20180016552A1

公开(公告)日：2018-01-18

申请号：US15506736

申请日：2015-08-27

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  SEOUL NATIONAL UNIVERSITY HOSPITAL

发明人： Sung Sup PARK ,  Ji Yeon KIM

IPC分类号： C12N5/079 ,  G01N33/50 ,  A61K35/30

CPC分类号： C12N5/0621 ,  A61K35/30 ,  C12N2501/105 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/599 ,  C12N2506/02 ,  C12N2506/45 ,  G01N33/5058 ,  G01N2800/168

摘要： Provided are a method of preparing retinal ganglion cells by differentiation of stem into retinal ganglion cells, retinal ganglion cells differentiated by the method, a method of screening for a death inhibitor or a proliferation promoter of retinal ganglion cells using the retinal ganglion cells differentiated by the method, a kit of screening for the death inhibitor or the proliferation promoter of retinal ganglion cells including the retinal ganglion cells differentiated by the method, a pharmaceutical composition for treating glaucoma or optic neuropathy including the retinal ganglion cells, a method of treating glaucoma or optic neuropathy including the step of administering the retinal ganglion cells to a subject suspected of having glaucoma or optic neuropathy, and a method of preparing a mature retinal ganglion cell line.

公开(公告)号：US07807363B2

公开(公告)日：2010-10-05

申请号：US11680416

申请日：2007-02-28

申请人： Wan-Heng Wang ,  Loretta Graves McNatt ,  Abbot F. Clark ,  Peter G. Klimko

发明人： Wan-Heng Wang ,  Loretta Graves McNatt ,  Abbot F. Clark ,  Peter G. Klimko

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/34 ,  G01N33/53 ,  C07H21/04

CPC分类号： G01N33/6893 ,  A61K31/21 ,  A61K31/4196 ,  A61K31/56 ,  C12Q1/26 ,  C12Q1/6851 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2500/00 ,  G01N2800/168

摘要： The present invention concerns a method for diagnosing or monitoring elevated intraocular pressure or glaucoma in a patient comprising providing a biological sample from the patient and measuring the expression level of a superoxide dismutase-2 (SOD-2) gene in the biological sample. The present invention also concerns methods for treating glaucoma or elevated intraocular pressure in a patient comprising administering to a patient an effective amount of an agent that modulates SOD-2 expression or SOD-2 activity.

摘要翻译： 本发明涉及用于诊断或监测患者中升高的眼内压或青光眼的方法，包括从患者提供生物样品并测量生物样品中超氧化物歧化酶-2（SOD-2）基因的表达水平。 本发明还涉及治疗患者青光眼或升高的眼内压的方法，包括向患者施用有效量的调节SOD-2表达或SOD-2活性的药剂。

公开(公告)号：US07807355B2

公开(公告)日：2010-10-05

申请号：US11327051

申请日：2006-01-06

申请人： Abbot F. Clark ,  John Fingert ,  Loretta McNatt ,  Edwin M. Stone ,  Wan-Heng Wang

发明人： Abbot F. Clark ,  John Fingert ,  Loretta McNatt ,  Edwin M. Stone ,  Wan-Heng Wang

IPC分类号： C12Q1/00 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： G01N33/5091 ,  A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12Q1/485 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/168

摘要： Methods and compositions for diagnosing and treating glaucoma are disclosed.

摘要翻译： 公开了用于诊断和治疗青光眼的方法和组合物。

公开(公告)号：US20050170353A1

公开(公告)日：2005-08-04

申请号：US10509595

申请日：2003-03-19

申请人： Kaoru Asano ,  Takayuki Takahata ,  Shigehiro Numada ,  Akinori Masago ,  Yasuhiro Kouchi

发明人： Kaoru Asano ,  Takayuki Takahata ,  Shigehiro Numada ,  Akinori Masago ,  Yasuhiro Kouchi

IPC分类号： C12Q1/68 ,  G01N33/68

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6887 ,  G01N2800/168

摘要： To provide a gene examination method for predicting the onset risk of glaucoma based on the relation between a glaucoma-associated gene and the onset of glaucoma, the onset of glaucoma in future is predicted by using as an indication mutations in the gene region involving the code region and/or the upstream region of a glaucoma-associated gene. In the base sequence represented by SEQ ID NO:1, mutation(s) in at least one of the following positions are detected, i.e., the 194-, 199-, 324-, 1051-, 1084-, 1627-, 1685-, 1756-, 1853-, 2830-, 3371-, 4037- and 4364-positions.

摘要翻译： 为了提供基于青光眼相关基因与青光眼发生之间的关系来预测青光眼的发病风险的基因检查方法，通过使用涉及代码的基因区域中的指示突变来预测未来的青光眼发作 区域和/或青光眼相关基因的上游区域。 在由SEQ ID NO：1表示的碱基序列中，检测至少一个以下位置的突变，即194-，199-，324-，1051-，1084-，1627-，1685- ，1756-，1853-，2830-，3371-4037-和4364-位。

公开(公告)号：US20230260126A1

公开(公告)日：2023-08-17

申请号：US18305789

申请日：2023-04-24

申请人： Google LLC

发明人： Lily Hao Yi Peng ,  Dale R. Webster ,  Philip Charles Nelson ,  Varun Gulshan ,  Marc Adlai Coram ,  Martin Christian Stumpe ,  Derek Janme Wu ,  Arunachalam Narayanaswamy ,  Avinash Vaidyanathan Varadarajan ,  Katharine Blumer ,  Yun Liu ,  Ryan Poplin

IPC分类号： G06T7/00 ,  G16H50/30 ,  G16H50/20 ,  G06N3/044 ,  G06N3/08

CPC分类号： G06T7/0016 ,  G16H50/30 ,  G16H50/20 ,  G06N3/044 ,  G06N3/08 ,  G01N2800/168 ,  G01N2800/164 ,  G06T2207/10016 ,  G06T2207/20076 ,  G06T2207/20081 ,  G06T2207/30041

摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing fundus images using fundus image processing machine learning models. One of the methods includes obtaining a model input comprising one or more fundus images, each fundus image being an image of a fundus of an eye of a patient; processing the model input using a fundus image processing machine learning model, wherein the fundus image processing machine learning model is configured to process the model input comprising the one or more fundus image to generate a model output; and processing the model output to generate health analysis data.

公开(公告)号：US20180162871A1

公开(公告)日：2018-06-14

申请号：US15553970

申请日：2016-02-29

申请人： The University of Tokyo ,  Tohoku University

发明人： Yasuteru Urano ,  Yuri Nagayo ,  Mako Kamiya ,  Toru Nakazawa

IPC分类号： C07D493/10 ,  C12Q1/37 ,  G01N33/58

CPC分类号： C07D493/10 ,  A61K49/0041 ,  C12Q1/37 ,  G01N21/78 ,  G01N33/582 ,  G01N2333/96466 ,  G01N2800/168

摘要： [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity.[Solution] A compound represented by the following general formula (I) or a salt thereof.

公开(公告)号：US20090036371A1

公开(公告)日：2009-02-05

申请号：US12038673

申请日：2008-02-27

申请人： Abbot F. CLARK ,  Wan-Heng WANG ,  Loretta MCNATT

发明人： Abbot F. CLARK ,  Wan-Heng WANG ,  Loretta MCNATT

IPC分类号： A61K38/00 ,  A61K31/216 ,  A61K31/192 ,  A61P27/00

CPC分类号： A61K38/046 ,  A61K31/385 ,  G01N33/5023 ,  G01N2333/4709 ,  G01N2500/02 ,  G01N2800/168

摘要： The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.

摘要翻译： 本发明提供了用于治疗青光眼的组合物和方法，用于诊断青光眼的方法，以及用于鉴定可用于治疗青光眼的药剂的方法。 更具体地，本发明描述了调节血清淀粉样蛋白A表达的试剂的用途。

公开(公告)号：US20080305103A1

公开(公告)日：2008-12-11

申请号：US12154396

申请日：2008-05-22

申请人： H. Uri Saragovi

发明人： H. Uri Saragovi

IPC分类号： A61K39/395 ,  A61K38/16 ,  G01N33/68 ,  C12Q1/68 ,  C07H21/04 ,  A61P27/06

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K2317/76 ,  G01N33/5308 ,  G01N2800/168

摘要： The present invention relates to methods to treat glaucoma and glaucoma-related conditions through the regulation of changes in gene expression that are mediated by high intraocular pressure or α2 macgroglobulin administration. Glaucoma, retinal ganglion cell (RGC) death and chronic ocular hypertension are treated using pharmaceutical compositions which comprise substances that inhibit the expression or activity of intraocular pressure-regulated early genes (IPREGs) or their gene products that are up-regulated by high intraocular pressure or α2 macgroglobulin administration and/or which increase the expression or activity of IPREGs or their gene products that are down-regulated by high intraocular pressure or α2 macgroglobulin administration. The invention also relates to methods of identifying an IPREG and methods to test for chronic ocular degeneration and the onset of RGC stress in an individual by measuring the expression level of IPREG proteins.

摘要翻译： 本发明涉及通过调节由高眼内压或α2巨球蛋白给药介导的基因表达变化来治疗青光眼和青光眼相关病症的方法。 使用药物组合物治疗青光眼，视网膜神经节细胞（RGC）死亡和慢性高眼压症，其包括抑制眼内压调节的早期基因（IPREG）或其高眼内压上调的基因产物的表达或活性的物质 或α2巨球蛋白给药和/或增加由高眼内压或α2巨溴蛋白给药下调的IPREG或其基因产物的表达或活性。 本发明还涉及通过测量IPREG蛋白的表达水平来鉴定IPREG的方法和测试个体中慢性眼变性和RGC应激发作的方法。

公开(公告)号：US20080058429A1

公开(公告)日：2008-03-06

申请号：US10545455

申请日：2004-02-13

申请人： A Louis Southren ,  Bernard I. Weinstein ,  Victor A. Fried

发明人： A Louis Southren ,  Bernard I. Weinstein ,  Victor A. Fried

IPC分类号： A61K47/00 ,  A61P43/00 ,  G01N33/53

CPC分类号： G01N33/6893 ,  G01N2333/904 ,  G01N2500/10 ,  G01N2800/168

摘要： The invention provides methods for diagnosing patients with primary open angle glaucoma (POAG), as well as methods for identifying agents for use in treating POAG and methods of using such agents in prevention and treatment of the disease.

摘要翻译： 本发明提供用于诊断原发性开角型青光眼（POAG）患者的方法，以及用于鉴定用于治疗POAG的药剂的方法以及在预防和治疗疾病中使用这些药剂的方法。