-
公开(公告)号:US20240216913A1
公开(公告)日:2024-07-04
申请号:US18562149
申请日:2022-05-26
发明人: Gianni Medoro , Giulio Signorini
IPC分类号: B01L3/00 , G01N15/10 , G01N15/14 , G01N15/1433 , G16B40/10
CPC分类号: B01L3/502715 , B01L3/502761 , G01N15/1433 , G01N15/1484 , G16B40/10 , B01L2200/0652 , B01L2300/0663 , B01L2400/0487 , G01N2015/1006 , G01N2015/1027 , G01N2015/1497
摘要: Method and microfluidic system (1) for the manipulation of particles; a detection device (7) acquires images of a specific particle (5) in a first position (IP) and in a second position (IIP); the difference is made between the two images in order to obtain a derived image in which the contours and the morphological characteristics of the specific particle (5) are more evident; in this manner, the type and the position of the particles can be identified more clearly, continuously and in a time-saving manner.
-
公开(公告)号:US12019028B2
公开(公告)日:2024-06-25
申请号:US17383781
申请日:2021-07-23
CPC分类号: G01N21/8806 , G01N15/10 , G02B6/3885 , G01N2015/1027 , G01N2201/06113
摘要: A method of foreign object debris discrimination includes illuminating a particle located within a sensing volume with a modulated electromagnetic radiation pulse emitted from a source; receiving one or more electromagnetic radiation return signals that have been scattered by the particle illuminated by the modulated electromagnetic radiation pulse at a detector; mixing, using a controller, the electromagnetic radiation return signal of amplitude IRS and frequency fRS with a reference signal of amplitude ILS and frequency fRS; analyzing, using the controller, an amplitude of the mixed signal √{square root over (ILSIRS)}, and frequency of the mixed signal, fRS−fLS; and classifying, using the controller, a particle position, a velocity, and electromagnetic characteristic of the particle based on the amplitude, √{square root over (ILSIRS)}, and frequency, fRS−fLS of the mixed signal.
-
公开(公告)号:US11988636B2
公开(公告)日:2024-05-21
申请号:US16858432
申请日:2020-04-24
发明人: Makoto Kawano , Ayako Tatematsu , Ryosuke Abe
IPC分类号: G01N27/76 , A23L27/00 , A23P10/30 , B01J13/02 , G01N15/00 , G01N15/10 , G01N15/1031 , B01J13/04
CPC分类号: G01N27/76 , A23L27/72 , A23P10/30 , G01N15/1031 , B01J13/02 , B01J13/04 , G01N2015/0038 , G01N2015/1027
摘要: The method for particle analysis includes a first magnetic susceptibility measurement step S4 of measuring a volume magnetic susceptibility of each of first particles p1; an encapsulation treatment step S5 of performing an encapsulation treatment so that the first particles p1 encapsulate an encapsulation target component pt smaller than the first particles p1; a second magnetic susceptibility measurement step S8 of measuring a volume magnetic susceptibility of each of second particles p2 as an analysis target that are the first particles p1 after the encapsulation treatment; and a step S9 of analyzing whether or not the encapsulation target component pt is encapsulated in the second particles p2 based on a result of measurement in the first magnetic susceptibility measurement step S4 and a result of measurement in the second magnetic susceptibility measurement step S8.
-
公开(公告)号:US20240329074A1
公开(公告)日:2024-10-03
申请号:US18601690
申请日:2024-03-11
发明人: Aaron Ewoniuk , Dylan Miller , Kevin Talucci
IPC分类号: G01N35/10 , B01L3/02 , G01F15/075 , G01F22/00 , G01N1/31 , G01N15/10 , G01N15/14 , G01N35/00
CPC分类号: G01N35/1016 , B01L3/0241 , G01F15/075 , G01F22/00 , G01N1/312 , G01N15/1459 , G01N35/00663 , G01N35/00722 , G01N35/1002 , B01L2200/061 , B01L2200/14 , B01L2200/143 , G01N2015/1027 , G01N2015/1493 , G01N2035/00673 , G01N2035/009
摘要: A system and method for dispense characterization is disclosed. According to particular embodiments of the dispense characterization system and method, volumes of dispensed liquids can be determined. In more particular embodiments, additional characteristics, and combinations of characteristics of a liquid dispensing event can be determined. Examples of additional characteristics that can be determined include the shape of the dispensing event, the velocity of the dispensing event, and the trajectory of the dispensing event. The dispense characterization system and method can be employed in automated biological sample analysis systems, and are particularly suited for monitoring liquid reagent dispensing events that deliver liquid reagents to a surface of a microscope slide holding a biological sample.
-
公开(公告)号:US12050169B2
公开(公告)日:2024-07-30
申请号:US17430191
申请日:2020-03-20
发明人: Chad E. Plattner , Philip Steiner
IPC分类号: G01N15/14 , A01C7/10 , G01N15/00 , G01N15/10 , G01N15/1434
CPC分类号: G01N15/1459 , A01C7/105 , G01N15/1434 , G01N2015/0046 , G01N2015/1027 , G01N2015/1486 , G01N2015/1493
摘要: In one embodiment a first light plane is generated across the passageway by a first LED emitter array. A corresponding photodiode receiver array detects particles passing through a first number of light channels comprising the first light plane. In a second embodiment a second light plane is generated across the passageway at 90 degrees from the first light plane and longitudinally offset from the first light plane by a second LED emitter array. A corresponding photodiode receiver array detects particles passing through a second number of light channels comprising the second light plane. The second light plane is capable of identifying particles in a third dimension that may go undetected when passing through the first light plane. The raw output signals generated by respective photodiodes is normalized, analyzed and characterized to differentiate between particles passing through light planes as individual particles or groups of overlapping particles to be separately counted.
-
公开(公告)号:US20240219288A1
公开(公告)日:2024-07-04
申请号:US18397259
申请日:2023-12-27
发明人: Ondrej MANDULA
IPC分类号: G01N15/149 , G01N15/01 , G01N15/10 , G01N15/1433 , G01N15/1434
CPC分类号: G01N15/149 , G01N15/01 , G01N15/1433 , G01N15/1434 , G01N2015/1027
摘要: Method for observing an emission of fluorescence light or luminescence light from a moving particle in a sample, in a spectral emission band, the method comprising:
a) forming a detection image of the sample in a spectral detection band, the spectral detection band being different from the spectral emission band;
b) forming an emission image of the sample in the spectral emission band;
the method being such that:
steps a) and b) are reiterated;
the method comprising:
c) on the basis of each detection image resulting from step a) of each iteration of steps a) and b), detecting the particle and determining a region of interest around the particle;
d) on the basis of the region of interest resulting from each step c), extracting a region of interest from each emission image of the sample.-
公开(公告)号:US12025548B2
公开(公告)日:2024-07-02
申请号:US18520776
申请日:2023-11-28
发明人: Ung Hyeon Ko , Seung Jin Kang , Eun Young Park
IPC分类号: G01N15/1031 , G01N15/10 , G01N33/487 , G01N33/49 , G01N15/01
CPC分类号: G01N15/1031 , G01N15/1023 , G01N33/48707 , G01N33/49 , G01N2015/012 , G01N2015/1027 , G01N2015/1029
摘要: The present technology relates to systems and associated methods for measuring properties of particles in a solution. In one or more embodiments, a particle measurement system is configured to generate a reference signal, communicate the reference signal across a plurality of resistors and overlapping pairs of electrodes that define detection regions for particulates traveling through a microchannel, and measure various properties of the particles based on detecting changes in the communicated reference signal.
-
公开(公告)号:US20240319106A1
公开(公告)日:2024-09-26
申请号:US18668764
申请日:2024-05-20
申请人: RTX Corporation
CPC分类号: G01N21/8806 , G01N15/10 , G02B6/3885 , G01N2015/1027 , G01N2201/06113
摘要: A method of foreign object debris discrimination includes illuminating a particle located within a sensing volume with a modulated electromagnetic radiation pulse emitted from a source; receiving one or more electromagnetic radiation return signals that have been scattered by the particle illuminated by the modulated electromagnetic radiation pulse at a detector; mixing, using a controller, the electromagnetic radiation return signal of amplitude IRS and frequency fRS with a reference signal of amplitude ILS and frequency fRS; analyzing, using the controller, an amplitude of the mixed signal √{square root over (ILSIRS)}, and frequency of the mixed signal, fRS−fLS; and classifying, using the controller, a particle position, a velocity, and electromagnetic characteristic of the particle based on the amplitude, √{square root over (ILSIRS)}, and frequency, fRS−fLS, of the mixed signal.
-
公开(公告)号:US20240319091A1
公开(公告)日:2024-09-26
申请号:US18579572
申请日:2022-07-18
申请人: REFEYN LTD
发明人: Matthias LANGHORST , Joshua BISHOP
IPC分类号: G01N21/45 , G01N15/0227 , G01N15/10 , G01N15/14 , G01N15/1433 , G01N15/1434 , G01N33/543 , G03H1/32
CPC分类号: G01N21/45 , G01N15/0227 , G01N15/1433 , G01N15/1434 , G01N33/54373 , G03H1/32 , G01N2015/1021 , G01N2015/1027 , G01N2015/1454 , G01N2015/1493 , G03H2210/62 , G03H2222/43 , G03H2223/52
摘要: The present invention relates to an improved method for determining the identity of a biomolecule using interferometric light scattering apparatus, notably distinguishing between variants of biomolecules, such as viral serotypes and the like. Such a method has potential to simplify the testing for biological manufacture and for diagnosing disease, monitoring environmental issues and determination of contaminants.
-
公开(公告)号:US20240302263A1
公开(公告)日:2024-09-12
申请号:US18667795
申请日:2024-05-17
申请人: Travera, Inc.
发明人: Robert Kimmerling , Selim Olcum , Mark Stevens
CPC分类号: G01N15/10 , G01N9/002 , G01N33/5005 , G01N2015/1021 , G01N2015/1027
摘要: The invention provides devices and methods for linked multimodal measurements of individual particles using a mass sensor and an additional sensor.
-
-
-
-
-
-
-
-
-