公开(公告)号：US20230119020A1

公开(公告)日：2023-04-20

申请号：US17729644

申请日：2022-04-26

申请人： Travera, Inc.

发明人： Robert Kimmerling ,  Selim Olcum ,  Mark Stevens

IPC分类号： G01N33/50 ,  B01L3/00

摘要： The present invention includes methods and systems for assessing a cellular response to a treatment modality, such as potential drug candidate, by comparing normalized single-cell measurements of cellular properties without the need of a calibration step.

公开(公告)号：US11530974B1

公开(公告)日：2022-12-20

申请号：US17729651

申请日：2022-04-26

申请人： Travera, Inc.

发明人： Robert Kimmerling ,  Selim Olcum ,  Mark Stevens

IPC分类号： G01N15/10 ,  G01N33/50 ,  G01N9/00

摘要： The invention provides devices and methods for linked multimodal measurements of individual particles using a mass sensor and an additional sensor.

公开(公告)号：US20220252487A1

公开(公告)日：2022-08-11

申请号：US17732769

申请日：2022-04-29

申请人： Travera, Inc.

发明人： Robert Kimmerling ,  Anthony Minnah ,  Selim Olcum ,  Mark Stevens ,  Madeleine Vacha

IPC分类号： G01N1/28 ,  B01L3/00

摘要： Methods of calibration are provided. A method comprises introducing a material with cell-like properties and a known mass into a sensor on a measurement instrument to generate a calibration reading and adjusting an output module of the measurement instrument until the measurement instrument calibrates to the known mass for the material.

公开(公告)号：US20240302263A1

公开(公告)日：2024-09-12

申请号：US18667795

申请日：2024-05-17

申请人： Travera, Inc.

发明人： Robert Kimmerling ,  Selim Olcum ,  Mark Stevens

IPC分类号： G01N15/10 ,  G01N9/00 ,  G01N33/50

CPC分类号： G01N15/10 ,  G01N9/002 ,  G01N33/5005 ,  G01N2015/1021 ,  G01N2015/1027

摘要： The invention provides devices and methods for linked multimodal measurements of individual particles using a mass sensor and an additional sensor.

公开(公告)号：US12105081B2

公开(公告)日：2024-10-01

申请号：US17729644

申请日：2022-04-26

申请人： Travera, Inc.

发明人： Robert Kimmerling ,  Selim Olcum ,  Mark Stevens

IPC分类号： G01N33/50 ,  B01L3/00

CPC分类号： G01N33/5011 ,  B01L3/502761 ,  G01N33/5032 ,  B01L2200/0652

摘要： The present invention includes methods and systems for assessing a cellular response to a treatment modality, such as potential drug candidate, by comparing normalized single-cell measurements of cellular properties without the need of a calibration step.

公开(公告)号：US20230288309A1

公开(公告)日：2023-09-14

申请号：US18083704

申请日：2022-12-19

申请人： Travera, Inc.

发明人： Robert Kimmerling ,  Selim Olcum ,  Mark Stevens

IPC分类号： G01N15/10 ,  G01N33/50 ,  G01N9/00

CPC分类号： G01N15/10 ,  G01N9/002 ,  G01N33/5005 ,  G01N2015/1043 ,  G01N2015/1075

摘要： The invention provides devices and methods for linked multimodal measurements of individual particles using a mass sensor and an additional sensor.

公开(公告)号：US20230165956A1

公开(公告)日：2023-06-01

申请号：US17977341

申请日：2022-10-31

申请人： Travera, Inc.

发明人： Robert Kimmerling ,  Selim Olcum ,  Mark Stevens ,  Anthony Minnah ,  Madeleine Vacha

IPC分类号： A61K39/395 ,  A61K35/17

CPC分类号： A61K39/395 ,  A61K35/17

摘要： The invention provides methods for assessing immune system function and status based on cellular analysis. Methods of the present invention involve obtaining mass properties of immune cells collected in a tissue or body fluid sample from a subject. Such mass properties may include the mass of one or more immune cells and/or changes in mass of such immune cells over a period of time. Such data is then used for determining a status of the subject's immune response, and subsequent diagnosis and treatment of an infection or immunological disease or dysfunction.