公开(公告)号：US20230303985A1

公开(公告)日：2023-09-28

申请号：US18046131

申请日：2022-10-12

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Antonio IAVARONE ,  Anna LASORELLA ,  Raul RABADAN

IPC: C12N9/12 ,  C07K14/71 ,  C07K14/47 ,  C12N9/16 ,  A61K38/17 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  G01N33/574 ,  A61K31/517 ,  C07K14/435 ,  C07K16/40 ,  C12Q1/6886 ,  G01N33/573

CPC classification number: C12N9/12 ,  C07K14/71 ,  C07K14/47 ,  C12N9/16 ,  C12Y301/03003 ,  A61K38/179 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  G01N33/57484 ,  A61K31/517 ,  C07K14/435 ,  C07K14/4738 ,  C07K16/40 ,  C12Q1/6886 ,  G01N33/573 ,  C07K2319/00 ,  G01N2333/71 ,  C07K2317/76 ,  C12Y207/10001

Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.

公开(公告)号：US20190203188A1

公开(公告)日：2019-07-04

申请号：US16246167

申请日：2019-01-11

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Antonio Iavarone ,  Anna Lasorella ,  Raul Rabadan

IPC: C12N9/12 ,  C07K14/435 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61K38/17 ,  C12Q1/6886 ,  A61K31/517 ,  G01N33/573 ,  C07K14/47 ,  C07K16/40 ,  C12N9/16 ,  C07K14/71 ,  G01N33/574 ,  A61K31/53 ,  A61K31/519 ,  A61K31/506 ,  A61K31/496

CPC classification number: C12N9/12 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K38/179 ,  C07K14/435 ,  C07K14/47 ,  C07K14/4738 ,  C07K14/71 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/00 ,  C12N9/16 ,  C12Q1/6886 ,  C12Y207/10001 ,  C12Y301/03003 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/71 ,  A61K2300/00

Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.

公开(公告)号：US09689009B2

公开(公告)日：2017-06-27

申请号：US13278106

申请日：2011-10-20

Applicant: Jin Sook Chang ,  Jae Hyun Jo ,  Hyun Ae Bae ,  Byeong Cheol Song ,  Sol Kim ,  Hye Won Kim ,  Hye Won Um ,  Sung Hoo Jhon ,  Yong Uk Shin ,  Eun Bin Yang ,  Kyoung Min Lee ,  Soo An Shin

Inventor： Jin Sook Chang ,  Jae Hyun Jo ,  Hyun Ae Bae ,  Byeong Cheol Song ,  Sol Kim ,  Hye Won Kim ,  Hye Won Um ,  Sung Hoo Jhon ,  Yong Uk Shin ,  Eun Bin Yang ,  Kyoung Min Lee ,  Soo An Shin

IPC: C12P13/12 ,  C12P13/06 ,  C12N9/10 ,  C12N9/16 ,  C12N15/70 ,  C12N15/77

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12N9/16 ,  C12N15/70 ,  C12N15/77 ,  C12P13/06 ,  C12Y205/01065 ,  C12Y301/03003

Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.

公开(公告)号：US20120190081A1

公开(公告)日：2012-07-26

申请号：US13278102

申请日：2011-10-20

Applicant: Jin Sook CHANG ,  Jae Hyun JO ,  Hyun Ae BAE ,  Byeong Cheol SONG ,  Sol KIM ,  Hye Won KIM

Inventor： Jin Sook CHANG ,  Jae Hyun JO ,  Hyun Ae BAE ,  Byeong Cheol SONG ,  Sol KIM ,  Hye Won KIM

IPC: C12P13/12 ,  C12N1/21

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12N9/16 ,  C12N15/70 ,  C12N15/77 ,  C12P13/06 ,  C12Y205/01065 ,  C12Y301/03003

Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.

Abstract translation: 本发明提供了通过培养具有降低的内源磷酸丝氨酸磷酸酶活性的微生物来制备半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。

公开(公告)号：US20030114656A1

公开(公告)日：2003-06-19

申请号：US10321382

申请日：2002-12-18

Applicant: AJINOMOTO CO. INC

Inventor： Mikiko Suga ,  Yoko Asakura ,  Masakazu Sugimoto ,  Hisao Ito

IPC: C07H021/04 ,  C12N009/16

CPC classification number: C12Y301/03003 ,  C12N9/16 ,  C12P13/06

Abstract: The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that complicates serB deficiency of Escherichia coli as a open reading frame in the DNA fragment. (A) A protein which comprises an amino acid sequence of SEQ ID: 2 in Sequence Listing; or (B) A protein which comprises an amino acid sequence including substitution, deletion, insertion, addition or inversion of one or several amino acids in the amino acid sequence of SEQ ID NO: 2 in Sequence Listing, and which has phosphoserine phosphatase activity.

公开(公告)号：US20180016546A1

公开(公告)日：2018-01-18

申请号：US15545513

申请日：2016-01-27

Applicant: Danmarks Tekniske Universitet

Inventor： Hemanshu Mundhada ,  Alex Toftgaard Nielsen

IPC: C12N1/36 ,  C12N9/88 ,  C12P13/06 ,  C12N9/10 ,  C12N9/04 ,  C07K14/32 ,  C12N9/16

CPC classification number: C12N1/36 ,  C07K14/245 ,  C07K14/32 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1014 ,  C12N9/1096 ,  C12N9/1205 ,  C12N9/1217 ,  C12N9/1247 ,  C12N9/16 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12N15/01 ,  C12N15/52 ,  C12P13/001 ,  C12P13/06 ,  C12P13/12 ,  C12P13/22 ,  C12P17/165 ,  C12P17/167 ,  C12Y101/01003 ,  C12Y101/01095 ,  C12Y201/02001 ,  C12Y206/01052 ,  C12Y207/02003 ,  C12Y301/03003 ,  C12Y403/01017

Abstract: The present invention generally relates to the microbiological industry, and specifically to the production of L-serine using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.

公开(公告)号：US20160108380A1

公开(公告)日：2016-04-21

申请号：US14853568

申请日：2015-09-14

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Antonio IAVARONE ,  Anna LASORELLA ,  Raul RABADAN

IPC: C12N9/12 ,  C07K14/435 ,  G01N33/573 ,  A61K31/517 ,  C12N9/16 ,  C12Q1/68 ,  C07K14/47 ,  C07K16/40

CPC classification number: C12N9/12 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K38/179 ,  C07K14/435 ,  C07K14/47 ,  C07K14/4738 ,  C07K14/71 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/00 ,  C12N9/16 ,  C12Q1/6886 ,  C12Y207/10001 ,  C12Y301/03003 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/71 ,  A61K2300/00

Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.

公开(公告)号：US08557549B2

公开(公告)日：2013-10-15

申请号：US13278105

申请日：2011-10-20

Applicant: Jin Sook Chang ,  Jae Hyun Jo ,  Hyun Ae Bae ,  Byeong Cheol Song ,  Sol Kim ,  Hye Won Kim

Inventor： Jin Sook Chang ,  Jae Hyun Jo ,  Hyun Ae Bae ,  Byeong Cheol Song ,  Sol Kim ,  Hye Won Kim

IPC: C12P13/12

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12N9/16 ,  C12N15/70 ,  C12N15/77 ,  C12P13/06 ,  C12Y205/01065 ,  C12Y301/03003

Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.

Abstract translation: 本发明提供了通过培养具有降低的内源性磷酸丝氨酸磷酸酶活性和提高磷酸甘油酸脱氢酶和/或磷酸丝氨酸氨基转移酶活性的微生物来生产半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。

公开(公告)号：US20060293513A1

公开(公告)日：2006-12-28

申请号：US11245030

申请日：2005-10-07

Applicant: Mikiko Suga ,  Yoko Asakura ,  Masakazu Sugimoto ,  Hisao Ito

Inventor： Mikiko Suga ,  Yoko Asakura ,  Masakazu Sugimoto ,  Hisao Ito

IPC: C12N9/16 ,  C07H21/04

CPC classification number: C12Y301/03003 ,  C12N9/16 ,  C12P13/06

Abstract: The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that complicates serB deficiency of Escherichia coli as a open reading frame in the DNA fragment. (A) A protein which comprises an amino acid sequence of SEQ ID: 2 in Sequence Listing; or (B) A protein which comprises an amino acid sequence including substitution, deletion, insertion, addition or inversion of one or several amino acids in the amino acid sequence of SEQ ID NO: 2 in Sequence Listing, and which has phosphoserine phosphatase activity.

公开(公告)号：US20230313243A1

公开(公告)日：2023-10-05

申请号：US18023462

申请日：2021-09-06

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Hye Min Park ,  So-Yeon Kim ,  Hee-jin Sim ,  Hyeryun Yoo ,  Jin Nam Lee

IPC: C12P13/06 ,  C12P13/12 ,  C12N9/04 ,  C12N9/10 ,  C12N9/16

CPC classification number: C12P13/06 ,  C12P13/12 ,  C12N9/0006 ,  C12Y101/01095 ,  C12N9/1096 ,  C12Y206/01052 ,  C12N9/16 ,  C12Y301/03003

Abstract: The present disclosure relates to a novel O-phosphoserine export protein, and a method for producing O-phosphoserine, cysteine, and cysteine derivatives using the same.