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1.发明申请公开(公告)号：US20170183693A1
公开(公告)日：2017-06-29
申请号：US15502328
申请日：2015-08-21
Applicant: Danmarks Tekniske Universitet
Inventor： Christian Bille Jendresen , Alex Toftgaard Nielsen
CPC classification number: C12P7/14 , C12N9/13 , C12N15/52 , C12N15/81 , C12P5/005 , C12P7/10 , C12P2201/00 , C12P2203/00 , C12Y207/01025 , C12Y207/07004 , C12Y208/02001 , C12Y301/03004 , Y02E50/16
Abstract: The present invention relates to the production of hydrolyzates from a lignocellulose-containing material, and to fermentation of the hydrolyzates. More specifically, the present invention relates to the detoxification of phenolic inhibitors and toxins formed during the processing of lignocellulose-containing material by enzymatically sulfating the phenolic inhibitors and toxins using aryl sulfotranseferases.
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公开(公告)号：US10544414B2
公开(公告)日：2020-01-28
申请号：US15521195
申请日：2015-10-22
Applicant: Danmarks Tekniske Universitet
Inventor： Alex Toftgaard Nielsen , Ariane Zutz , Rebecca Lennen
IPC: C12N15/10 , C12Q1/6897 , C12N15/70 , G01N33/50
Abstract: The present invention relates to a dual cassette reporter system capable of assessing target gene translation and target gene product folding. The present invention further relates to vectors and host cells comprising the dual cassette reporter system. In addition the invention relates to the use of the dual cassette reporter system for assessing target gene translation and target gene product folding.
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公开(公告)号：US20190002935A1
公开(公告)日：2019-01-03
申请号：US15781999
申请日：2016-12-07
Applicant: DANMARKS TEKNISKE UNIVERSITET
Inventor： Rebecca Lennen , Alex Toftgaard Nielsen , Markus Herrgård , Morten Sommer , Adam Feist , Elsayed Tharwat Tolba Mohamed
IPC: C12P13/00 , C07K14/255 , C07K14/245 , C12N9/12 , C12N9/80 , C12N9/16 , C12N9/00
Abstract: Provided are bacterial cells genetically modified to improve their tolerance to certain commodity chemicals, such as polyamines, and methods of preparing and using such bacterial cells for production of polyamines and other compounds.
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4.发明申请公开(公告)号：US20170355983A1
公开(公告)日：2017-12-14
申请号：US15521195
申请日：2015-10-22
Applicant: Danmarks Tekniske Universitet
Inventor： Alex Toftgaard Nielsen , Ariane Zutz , Rebecca Lennen
Abstract: The present invention relates to a dual cassette reporter system capable of assessing target gene translation and target gene product folding. The present invention further relates to vectors and host cells comprising the dual cassette reporter system. In addition the invention relates to the use of the dual cassette reporter system for assessing target gene translation and target gene product folding.
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公开(公告)号：US20240026391A1
公开(公告)日：2024-01-25
申请号：US18043177
申请日：2021-09-01
Applicant: Danmarks Tekniske Universitet
Inventor： Ivan Pogrebnyakov , Alex Toftgaard Nielsen
CPC classification number: C12P7/28 , C12P7/04 , C12N9/1029 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/0006 , C12N15/74 , C12Y203/01009 , C12Y208/03008 , C12Y208/03009 , C12Y208/03005 , C12Y401/01004 , C12Y101/0108
Abstract: The present invention relates to thermophilic cells and methods for the microbial production of volatile compounds, including acetone, butanone and isopropanol. Also provided are nucleic acid constructs, vectors and host cells useful in such methods.
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Patent Agency Ranking
公开(公告)号：US20230139445A1
公开(公告)日：2023-05-04
申请号：US16461170
申请日：2017-11-15
Applicant: DANMARKS TEKNISKE UNIVERSITET
Inventor： Rebecca Lennen , Alex Toftgaard Nielsen , Markus Herrgård , Morten Sommer , Adam Feist , Elsayed Tharwat Tolba Mohamed
IPC: C12P7/46 , C12N1/20 , C12N15/52 , C07K14/245
Abstract: The present invention relates to bacterial cells genetically modified to improve their tolerance to certain commodity chemicals, such as diacids, and to methods of preparing and using such bacterial cells for production of diacids and other compounds.
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公开(公告)号：US20180010157A1
公开(公告)日：2018-01-11
申请号：US15545563
申请日：2016-01-27
Applicant: Danmarks Tekniske Universitet
Inventor： Hemanshu Mundhada , Alex Toftgaard Nielsen
Abstract: The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
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公开(公告)号：US20190284590A1
公开(公告)日：2019-09-19
申请号：US16079502
申请日：2017-02-24
Applicant: Danmarks Tekniske Universitet
Inventor： Christian Bille Jendresen , Alex Toftgaard Nielsen
Abstract: The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (e.g., expressing) a polypeptide having aryl sulfotransferase activity, wherein said recombinant host cells have been modified to have an increased uptake of sulfate compared to identical host cells that does not carry said modification. Further provided are processes for the production of aryl sulfates, such as zosteric acid, employing such recombinant host cells.
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公开(公告)号：US20170226543A1
公开(公告)日：2017-08-10
申请号：US15502322
申请日：2015-08-21
Applicant: Danmarks Tekniske Universitet
Inventor： Christian Bille Jendresen , Alex Toftgaard Nielsen
Abstract: The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using polypeptides or recombinant cells comprising said polypeptides. More particularly, the present invention pertains to polypeptides having aryl sulfotransferase activity, recombinant host cells expressing same and processes for the production of aryl sulfates employing these polypeptides or recombinant host cells.
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公开(公告)号：US20250059579A1
公开(公告)日：2025-02-20
申请号：US18720007
申请日：2022-12-16
Applicant: DANMARKS TEKNISKE UNIVERSITET
Abstract: Provided are thermophilic bacteria comprising an expression control system comprising a Tet repressor protein, use of such an expression system to control the expression of a gene of interest in thermophilic bacteria by temperature regulation and methods for producing a gene product of interest in thermophilic bacteria by using this system by temperature regulation.
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