公开(公告)号：US20180010157A1

公开(公告)日：2018-01-11

申请号：US15545563

申请日：2016-01-27

Applicant: Danmarks Tekniske Universitet

Inventor： Hemanshu Mundhada ,  Alex Toftgaard Nielsen

IPC: C12P13/06 ,  C12N15/52 ,  C12N9/12 ,  C12N9/10 ,  C12N9/04 ,  C12N9/88

Abstract: The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.

公开(公告)号：US20180016546A1

公开(公告)日：2018-01-18

申请号：US15545513

申请日：2016-01-27

Applicant: Danmarks Tekniske Universitet

Inventor： Hemanshu Mundhada ,  Alex Toftgaard Nielsen

IPC: C12N1/36 ,  C12N9/88 ,  C12P13/06 ,  C12N9/10 ,  C12N9/04 ,  C07K14/32 ,  C12N9/16

CPC classification number: C12N1/36 ,  C07K14/245 ,  C07K14/32 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1014 ,  C12N9/1096 ,  C12N9/1205 ,  C12N9/1217 ,  C12N9/1247 ,  C12N9/16 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12N15/01 ,  C12N15/52 ,  C12P13/001 ,  C12P13/06 ,  C12P13/12 ,  C12P13/22 ,  C12P17/165 ,  C12P17/167 ,  C12Y101/01003 ,  C12Y101/01095 ,  C12Y201/02001 ,  C12Y206/01052 ,  C12Y207/02003 ,  C12Y301/03003 ,  C12Y403/01017

Abstract: The present invention generally relates to the microbiological industry, and specifically to the production of L-serine using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.