Invention Grant
- Patent Title: Microorganism producing o-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same
-
Application No.: US13278106Application Date: 2011-10-20
-
Publication No.: US09689009B2Publication Date: 2017-06-27
- Inventor: Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
- Applicant: Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
- Applicant Address: KR Seoul
- Assignee: CJ CHEILJEDANG CORPORATION
- Current Assignee: CJ CHEILJEDANG CORPORATION
- Current Assignee Address: KR Seoul
- Agency: Cooley LLP
- Priority: KR10-2010-0102664 20101020; KR10-2011-0086081 20110826
- Main IPC: C12P13/12
- IPC: C12P13/12 ; C12P13/06 ; C12N9/10 ; C12N9/16 ; C12N15/70 ; C12N15/77
Abstract:
The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.
Public/Granted literature
Information query
