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    ATM related kinase ATX, nucleic acids encoding same and methods of use
    1.
    发明申请
    ATM related kinase ATX, nucleic acids encoding same and methods of use 失效
    ATM相关激酶ATX，编码相同的核酸和使用方法

    公开(公告)号：US20040248244A1

    公开(公告)日：2004-12-09

    申请号：US10456238

    申请日：2003-06-06

    发明人： Robert T. Abraham ,  Diane M. Otterness

    IPC分类号： C12Q001/68 ,  C12N009/16 ,  C07H021/04

    CPC分类号： C07H21/04 ,  C07K2319/00 ,  C12N9/1205

    摘要： The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as SEQ ID NO:2 is further provided as well as an antibody, or antigen binding fragment thereof, which specifically binds to an ATX polypeptide and has an amino acid sequence as referenced in SEQ ID NO:2. A method for identifying an ATX-modulatory compound is additionally provided. The method consists of measuring the level of an ATX polypeptide in the presence of a test compound, wherein a difference in the level of said ATX polypeptide in the presence of said test compound compared to in the absence of said test compound indicating that said test compound is an ATX-modulatory compound, and wherein said ATX-modulatory compound is not caffeine or wortmannin.

    摘要翻译： 本发明提供具有与SEQ ID NO：1基本相同的核苷酸序列的分离的核酸分子。 还提供了具有SEQ ID NO：11所示的核苷酸序列的至少15个连续核苷酸的分离的寡核苷酸。 还提供具有与SEQ ID NO：2基本上相同的氨基酸序列的分离的多肽以及特异性结合ATX多肽并具有SEQ ID NO：2所述的氨基酸序列的抗体或其抗原结合片段 ：2。 另外提供了鉴定ATX调节化合物的方法。 所述方法包括在存在测试化合物的情况下测量ATX多肽的水平，其中所述ATX多肽在所述测试化合物存在下的水平与不存在所述测试化合物相比的差异表明所述测试化合物 是ATX调节化合物，其中所述ATX调节化合物不是咖啡因或渥曼青霉素。

    Single nucleotide polymorphism in the FGF-3 gene and methods of use thereof
    3.
    发明申请
    Single nucleotide polymorphism in the FGF-3 gene and methods of use thereof 审中-公开
    FGF-3基因中的单核苷酸多态性及其使用方法

    公开(公告)号：US20040219582A1

    公开(公告)日：2004-11-04

    申请号：US10798652

    申请日：2004-03-11

    发明人： Yongjun Guo

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12N009/16

    CPC分类号： C07K14/50 ,  C07H21/04 ,  C12Q1/6886 ,  C12Q2600/156

    摘要： A single nucleotide polymorphism (SNP) in the 5null untranslated region of the FGF-3 gene, which indicates cancer susceptibility is disclosed. Also disclosed are methods and kits for detecting this SNP in the FGF-3 gene.

    摘要翻译： 公开了FGF-3基因的5'非翻译区域中的单核苷酸多态性（SNP），其表示癌症易感性。 还公开了用于检测FGF-3基因中的该SNP的方法和试剂盒。

    Phytic acid biosynthetic enzymes
    4.
    发明申请
    Phytic acid biosynthetic enzymes 有权
    植酸生物合成酶

    公开(公告)号：US20040219561A1

    公开(公告)日：2004-11-04

    申请号：US10629950

    申请日：2003-07-20

    发明人： Rebecca E. Cahoon ,  Catherine J. Thorpe ,  William D. Hitz ,  Scott V. Tingey

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12N009/16

    CPC分类号： C12N9/1205 ,  C12N9/16 ,  C12N15/8243

    摘要： This invention relates to an isolated nucleic acid fragment encoding a phytic acid biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the phytic acid biosynthetic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the phytic acid biosynthetic enzyme in a transformed host cell.

    摘要翻译： 本发明涉及编码植酸生物合成酶的分离的核酸片段。 本发明还涉及在正义或反义方向上编码全部或部分植酸生物合成酶的嵌合基因的构建，其中嵌合基因的表达导致转化的植酸生物合成酶水平的变化 宿主细胞。

    Inhibitors of the inositol polyphosphate 5-phosphatase SHIP2 molecule
    5.
    发明申请
    Inhibitors of the inositol polyphosphate 5-phosphatase SHIP2 molecule 有权

    公开(公告)号：US20040209342A1

    公开(公告)日：2004-10-21

    申请号：US10742430

    申请日：2003-12-19

    申请人： Euroscreen, s.a.

    发明人： Christopher Erneux ,  Stephane Schurmans

    IPC分类号： C12N009/16

    CPC分类号： A61K31/683 ,  A61K31/35 ,  A61K33/24

    摘要： The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical composition comprising said inhibitor and an adequate pharmaceutically acceptable carrier or diluent and to a non-human knock-out mammal comprising homozygously or heterozygously a partial or total deletion in its genome of the inositol polyphoshate 5-phosphatase SHIP2 nucleotide sequence.

    Method for producing target substance
    8.
    发明申请
    Method for producing target substance 失效
    生产目标物质的方法

    公开(公告)号：US20040191875A1

    公开(公告)日：2004-09-30

    申请号：US10792647

    申请日：2004-03-04

    发明人： Ryo Takeshita ,  Hisashi Yasueda

    IPC分类号： C12P013/04 ,  C12N009/16 ,  C12N001/21

    CPC分类号： C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12P13/08

    摘要： The present invention discloses a method for producing a target substance using a coryneform bacterium comprising culturing a coryneform bacterium having an ability to produce the target substance in a medium, resulting in accumulation of the target substance in the medium or cells of the bacterium, and collecting the target substance from the medium or the cells of the bacterium. Also disclosed is a coryneform bacterium which is introduced with a methanol dehydrogenase gene and which has enhanced activities of hexulose phosphate synthase and phosphohexuloisomerase, and to which an ability to utilize methanol is imparted or which has enhanced ability to utilize methanol, and the medium contains methanol as a carbon source.

    摘要翻译： 本发明公开了一种使用棒状细菌生产目标物质的方法，包括培养在培养基中具有产生目标物质的能力的棒状细菌，导致目标物质在细菌的培养基或细胞中的积聚，并收集 来自培养基的目标物质或细菌的细胞。 还公开了一种引入了甲醇脱氢酶基因并且具有增强的己糖磷酸合成酶和磷酸己糖异构酶的活性的棒状细菌，并且其赋予使用甲醇的能力或具有增强的利用甲醇的能力，并且所述培养基含有甲醇 作为碳源。

    Phosphotriesterase from agrobacterium radiobacter p230
    9.
    发明申请
    Phosphotriesterase from agrobacterium radiobacter p230 有权
    来自农杆菌p230的磷酸鸟苷酶

    公开(公告)号：US20040161818A1

    公开(公告)日：2004-08-19

    申请号：US10477469

    申请日：2004-04-09

    发明人： Irene Horne ,  Tara Sutherland ,  Rebecca Harcourt ,  Robyn Russell ,  John Oakeshott

    IPC分类号： C12N009/16 ,  C07H021/04 ,  C12N001/20

    CPC分类号： C12N9/16 ,  C07K2319/00

    摘要： The present invention provides enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention provides a phosphotriesterase enzyme identified from an Agrobacterium radiobacter strain isolated from soil that hydrolyses OP pesticides, and the gene encoding that enzyme. The invention also provides mutants of the identified phosphotriesterase enzyme which have altered substrate specificity. The use of these enzymes in bioremediation strategies is also provided.

    摘要翻译： 本发明提供能够水解有机磷酸酯（OP）分子的酶。 特别地，本发明提供了从分离自水解OP农药的土壤中的放射性土壤杆菌菌株鉴定的磷酸三聚酶，以及编码该酶的基因。 本发明还提供已经改变的底物特异性的鉴定的磷酸三聚酶的突变体。 还提供了这些酶在生物修复策略中的使用。

    Canine L-PBE sequences
    10.
    发明申请
    Canine L-PBE sequences 审中-公开
    犬L-PBE序列

    公开(公告)号：US20040157249A1

    公开(公告)日：2004-08-12

    申请号：US10743884

    申请日：2003-12-22

    发明人： Yizhong Gu

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12N009/16 ,  C12N005/06

    CPC分类号： C12N9/0006

    摘要： The present invention provides a cDNA encoding a heretofore unknown polypeptide termed canine L-PBE; the canine L-PBE polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making and using all of the foregoing.

    摘要翻译： 本发明提供编码称为犬L-PBE的迄今为止未知多肽的cDNA; 由该基因编码的犬L-PBE多肽; 针对多肽的抗体; 以及制作和使用上述所有方法。