Abstract:
The invention provides methods for treating fibrosis, as well as methods for modulating mitochondrial peroxide production in a cell, and methods for modulating the import of Rac1 into the mitochondria of a cell.
Abstract:
The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Abstract:
The invention relates to copper(I) complexes of the formula A, in which X*═Cl, Br, I, CN and/or SCN (i.e. independently of one another); N*∩E=a bidentate ligand where E=phosphanyl/arsenyl group of the R2E form (where R=alkyl, aryl, alkoxyl, phenoxyl, or amide); N*=imine function, which is part of a N-heteroaromatic 5- or 6-membered ring, which is chosen from the group consisting of oxazole, imidazole, thiazole, isoxazole, isothiazole, pyrazole, 1,2,3-triazole, 1,2,3-oxadiazole, 1,2,5-oxadiazole, 1,2,3-thiadiazole and 1,2,5-thiadiazole, pyridine, pyrimidine, triazine, pyrazine and pyridazine; and “∩”=at least one carbon atom, which is likewise part of the aromatic group, wherein the carbon atom is directly adjacent to both the imine nitrogen atom and to the phosphorous or arsenic atom.
Abstract translation:本发明涉及式A的铜(I)络合物,其中X * = Cl,Br,I,CN和/或SCN(即彼此独立); N *∩E=二齿配位体,其中E = R2E形式的膦酰基/砷酰基(其中R =烷基,芳基,烷氧基,苯氧基或酰胺); N * =亚胺功能,其是N-杂芳族5-或6-元环的一部分,其选自恶唑,咪唑,噻唑,异恶唑,异噻唑,吡唑,1,2,3-三唑, 1,2,3-恶二唑,1,2,5-恶二唑,1,2,3-噻二唑和1,2,5-噻二唑,吡啶,嘧啶,三嗪,吡嗪和哒嗪; 和“∩”=至少一个碳原子,其同样是芳族基团的一部分,其中碳原子与亚胺氮原子和磷或砷原子直接相邻。
Abstract:
The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Abstract:
The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Abstract:
An OLED device comprises an anode and a cathode and having therebetween a light emitting layer containing an emissive material, wherein a layer between the anode and cathode contains a phosphineoxide compound bearing two or more tri(hetero)arylphosphineoxide groups, provided these groups are selected to give a compound with a Et≧2.65 eV.
Abstract:
The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose tolerance, diabetes, diabetic complications (diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, and diabetic macroangiopathy, hypertension, arteriosclerosis), hypertension, and arteriosclerosis.
Abstract:
The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose tolerance, diabetes, diabetic complications (diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, and diabetic macroangiopathy, hypertension, arteriosclerosis), hypertension, and arteriosclerosis.
Abstract:
The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding antibody and a ligand analog to form an antibody-ligand analog complex wherein the ligand analog is covalently bonded to a reporter molecule. This complex may additionally comprise a labeling protein non-covalently bonded to the antibody to form a ternary complex wherein the labeling protein comprises a monovalent antibody fragment or a non-antibody protein that is covalently bonded to a label moiety. The reporter molecule is either quenched by the ligand-binding antibody or by the label moiety of the labeling protein, depending on the reporter molecule and the ligand-binding antibody, wherein the amount of quenching is directly related to the amount of ligand present in the sample. Alternatively, the ligand analog is fluorogenic wherein the ligand analog is essentially non-fluorescent in solution but when bound by the ligand-binding antibody the detectable signal increases. In this instance a decrease in signal, as opposed to the relieving of quenching, is measured for the presence of a target ligand.
Abstract:
The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.