公开(公告)号：US12117439B2

公开(公告)日：2024-10-15

申请号：US18503564

申请日：2023-11-07

Applicant: 10x Genomics, Inc.

Inventor： Joshua Delaney ,  Shalini Gohil ,  Jill Herschleb ,  Adam Lowe ,  Albert Kim ,  Meiliana Tjandra

IPC: G01N33/53 ,  C07D213/04 ,  C07D239/24 ,  C12N9/48 ,  G01N33/50 ,  G01N1/30

CPC classification number: G01N33/5308 ,  C07D213/04 ,  C07D239/24 ,  C12N9/48 ,  G01N33/5047 ,  G01N2001/307 ,  G01N2333/948

Abstract: The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.

公开(公告)号：US20190013480A1

公开(公告)日：2019-01-10

申请号：US15839740

申请日：2017-12-12

Applicant: Samsung Display Co., Ltd.

Inventor： Hiroaki ITOI

IPC: H01L51/00 ,  C09K11/06 ,  C07D209/82 ,  C07D239/24 ,  C07D251/12

CPC classification number: H01L51/0072 ,  C07D209/82 ,  C07D239/24 ,  C07D251/12 ,  C09K11/06

Abstract: A heterocyclic compound represented by Formula 1 and an organic electroluminescence device including the same in an emission layer. In Formula 1, Z is represented by Formula 2-1 or 2-2. In Formula 2-2, X1 to X3 are each independently CR10 or N, and at least one of X1 to X3 is N.

公开(公告)号：US20180273476A1

公开(公告)日：2018-09-27

申请号：US15876960

申请日：2018-01-22

Applicant: Bionomics Limited ,  Merck Patent GmbH

Inventor： Andrew Harvey ,  Agnes Bombrun ,  Rachel Cooke ,  Isabelle Jeanclaude-Etter ,  Nathan Kuchel ,  Jerome Molette ,  Jorgen Mould ,  Dharam Paul ,  Rajinder Singh ,  Cristina Donini ,  Veronique Colovray ,  Thomas Avery ,  Julia Crossman ,  Justin Ripper

IPC: C07D213/40 ,  C07C217/90 ,  C07D413/12 ,  C07D451/04 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D237/08 ,  C07D239/24 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12

CPC classification number: C07D213/40 ,  C07C217/90 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D237/08 ,  C07D239/24 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D413/12 ,  C07D451/04

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：US20180244630A1

公开(公告)日：2018-08-30

申请号：US15757078

申请日：2016-09-08

Applicant: LG Chem, Ltd.

Inventor： Min Woo Jung ,  Dong Hoon Lee ,  Jungoh Huh ,  Boonjae Jang ,  Minyoung Kang ,  Dong Uk Heo ,  Miyeon Han

IPC: C07D239/24 ,  H01L51/50 ,  C07D251/12 ,  C07D401/14 ,  C07D403/14 ,  C09K11/06

CPC classification number: C07D239/24 ,  C07D251/12 ,  C07D401/14 ,  C07D403/14 ,  C09K11/06 ,  H01L51/50 ,  H01L51/5056

Abstract: The present specification provides a heterocyclic compound and an organic light emitting device using the same.

公开(公告)号：US20160228435A1

公开(公告)日：2016-08-11

申请号：US14879257

申请日：2015-10-09

Applicant: Cellceutix Corporation

Inventor： Richard W. Scott

IPC: A61K31/506 ,  A61K9/08 ,  A61K9/06 ,  A61K31/573 ,  A61K9/00

CPC classification number: A61K31/506 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/06 ,  A61K9/08 ,  A61K31/573 ,  A61K31/74 ,  A61K47/06 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07D239/02 ,  C07D239/24 ,  C07D239/28 ,  C07D403/14 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.

公开(公告)号：US09192623B2

公开(公告)日：2015-11-24

申请号：US13661466

申请日：2012-10-26

Applicant: Cellcutix Corporation

Inventor： Richard W. Scott

IPC: A61K31/74 ,  A61K31/506 ,  C07D239/02 ,  C07D239/24 ,  C07D239/28 ,  C07D403/14 ,  A61K47/06 ,  A61K47/18 ,  A61K47/38 ,  A61K9/00

CPC classification number: A61K31/506 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/06 ,  A61K9/08 ,  A61K31/573 ,  A61K31/74 ,  A61K47/06 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07D239/02 ,  C07D239/24 ,  C07D239/28 ,  C07D403/14 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.

Abstract translation: 本发明公开了表面两亲性抗微生物聚合物和低聚物及其用途的眼用和耳用组合物及其用途，包括其用于治疗和预防人和动物眼科感染和耳部感染的方法。

公开(公告)号：US08765766B2

公开(公告)日：2014-07-01

申请号：US13353287

申请日：2012-01-18

Applicant: Jean-Michel Lefrancois ,  Bertrand Heckmann

Inventor： Jean-Michel Lefrancois ,  Bertrand Heckmann

IPC: A61K31/506 ,  C07D239/24

CPC classification number: A61K31/506 ,  C07D239/24 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04

Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.

Abstract translation: 本发明的主题是式（I）的化合物; 其中R1，R2，R3，R4和R具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。

公开(公告)号：US20130065818A1

公开(公告)日：2013-03-14

申请号：US13661466

申请日：2012-10-26

Applicant: PolyMedix

Inventor： Richard W. Scott

IPC: A61K31/506 ,  A61P31/00 ,  A61P29/00 ,  A61P23/00 ,  A61P37/08 ,  A61P27/06 ,  A61P9/12 ,  A61K31/545 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/546 ,  A61K38/12 ,  A61K31/7056 ,  A61K31/56 ,  A61K31/573 ,  A61K31/575 ,  A61K31/57 ,  A61K31/5415 ,  A61K31/616 ,  A61K31/551 ,  A61K31/522 ,  A61K31/519 ,  A61P31/04 ,  C07D403/14

CPC classification number: A61K31/506 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/06 ,  A61K9/08 ,  A61K31/573 ,  A61K31/74 ,  A61K47/06 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07D239/02 ,  C07D239/24 ,  C07D239/28 ,  C07D403/14 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.

Abstract translation: 本发明公开了表面两亲性抗微生物聚合物和低聚物及其用途的眼用和耳用组合物及其用途，包括其用于治疗和预防人和动物眼科感染和耳部感染的方法。

公开(公告)号：US20090092574A1

公开(公告)日：2009-04-09

申请号：US11965194

申请日：2007-12-27

Applicant: Richard W. Scott

Inventor： Richard W. Scott

IPC: A61K31/74 ,  A61P27/02

CPC classification number: A61K31/506 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/06 ,  A61K9/08 ,  A61K31/573 ,  A61K31/74 ,  A61K47/06 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07D239/02 ,  C07D239/24 ,  C07D239/28 ,  C07D403/14 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.

Abstract translation: 本发明公开了表面两亲性抗微生物聚合物和低聚物及其用途的眼科和耳用组合物及其用途，包括其用于治疗和预防人和动物眼科感染和耳部感染的方法。

公开(公告)号：US20080221103A1

公开(公告)日：2008-09-11

申请号：US12073635

申请日：2008-03-07

Applicant: Ganapavarapu V.R. Sharma ,  Gaddam O. Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Sukunath Narayanan ,  Nagalakshmi Pichika ,  Venkatesh Nemmara Viswanathan ,  Lavanya Andiappan ,  Saravanan Thirunavukkarasu

Inventor： Ganapavarapu V.R. Sharma ,  Gaddam O. Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Sukunath Narayanan ,  Nagalakshmi Pichika ,  Venkatesh Nemmara Viswanathan ,  Lavanya Andiappan ,  Saravanan Thirunavukkarasu

IPC: A61K31/5377 ,  C07D239/24 ,  C07D413/14 ,  A61K31/435 ,  A61P37/06

CPC classification number: C07D239/24 ,  C07D413/14

Abstract: Provided herein are heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as described herein. Further described herein in particular are heterocyclic compounds of the formula (I) for treating various diseases. and disorders by administering in a patient one or more TNF-α, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-1; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-1, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).

Abstract translation: 本文提供了通式（I）的杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药，其中R 1， R 2，R 3，R 4和R 5如本文所述。 本文进一步描述的是用于治疗各种疾病的式（I）的杂环化合物。 以及通过在患者中施用一种或多种TNF-α，血栓烷合成酶，5-LOX和PDE4抑制剂的障碍。 本文特别描述的是用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 恶病质 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征; 发热和由于HIV-1介导的感染和疾病引起的肌痛; HIV-2; HIV-3; 巨细胞病毒（CMV）; 流感; 腺病毒 哺乳动物中的疱疹病毒（包括HSV-1，HSV-2）和带状疱疹病毒，包括施用有效量的式（I）化合物。