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公开(公告)号：US20150299184A1
公开(公告)日：2015-10-22
申请号：US14668272
申请日：2015-03-25
Applicant: Bionomics Limited , Merck Patent GmbH
Inventor： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
IPC: C07D451/04 , C07D405/12 , C07D237/08 , C07D213/64 , C07D411/12 , C07D401/12 , C07D213/40 , C07D241/12
CPC classification number: C07D213/40 , C07C217/90 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D451/04
Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
Abstract translation: 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
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公开(公告)号：US20180273476A1
公开(公告)日：2018-09-27
申请号：US15876960
申请日：2018-01-22
Applicant: Bionomics Limited , Merck Patent GmbH
Inventor： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
IPC: C07D213/40 , C07C217/90 , C07D413/12 , C07D451/04 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12
CPC classification number: C07D213/40 , C07C217/90 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D451/04
Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
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公开(公告)号：US09914702B2
公开(公告)日：2018-03-13
申请号：US15366513
申请日：2016-12-01
Applicant: Bionomics Limited , Merck Patent GmbH
Inventor： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
IPC: A61K31/497 , C07D213/40 , C07D309/14 , C07D213/89 , C07D231/12 , C07D233/56 , C07D401/12 , C07D237/08 , C07D239/24 , C07D405/12 , C07D411/12 , C07C217/90 , C07D413/12 , C07D241/12 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D241/18 , C07D451/04 , C07D239/34
CPC classification number: C07D213/40 , C07C217/90 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D451/04
Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
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公开(公告)号：US20170088519A1
公开(公告)日：2017-03-30
申请号：US15366513
申请日：2016-12-01
Applicant: Bionomics Limited , Merck Patent GmbH
Inventor： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
IPC: C07D213/40 , C07D239/34 , C07D213/64 , C07D213/89 , C07D401/12 , C07D451/04 , C07D413/12 , C07D237/08 , C07D405/12 , C07D411/12
CPC classification number: C07D213/40 , C07C217/90 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D451/04
Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
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