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1.发明授权公开(公告)号：US08133896B2
公开(公告)日：2012-03-13
申请号：US12911691
申请日：2010-10-25
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
IPC: A61K31/505 , C07D401/14
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物; 其中R1，R2，R3，R4和R具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。
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2.发明申请METHODS FOR THE USE OF PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONISTS OF VITRONECTIN RECEPTOR 有权使用维生素受体拮抗剂的吡嗪衍生物的使用方法公开(公告)号：US20100041675A1
公开(公告)日：2010-02-18
申请号：US12541876
申请日：2009-08-14
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物; 其中R1，R2，R3，R4和R具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。
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3.发明授权Vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same 有权玻连蛋白受体拮抗剂衍生物，其制备方法，其作为药物的用途和含有它们的药物组合物公开(公告)号：US07763621B2
公开(公告)日：2010-07-27
申请号：US12245622
申请日：2008-10-03
Applicant: Jean-Marie Ruxer , Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Marie Ruxer , Jean-Michel Lefrancois , Bertrand Heckmann
IPC: C07D471/04 , C07D401/14 , A61K31/506
CPC classification number: C07D401/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物：其中R1，R2，R3，R4和G具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途，以及 含有它们的药物组合物。
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4.发明申请公开(公告)号：US20080058348A1
公开(公告)日：2008-03-06
申请号：US11596597
申请日：2005-05-13
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
IPC: A61K31/505 , A61K31/506 , A61P13/12 , A61P19/10 , A61P35/00 , A61P9/00 , A61P9/10 , C07D239/24
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物; 其中R 1，R 2，R 3，R 4和R 4具有说明书中所示的含义 ，它们的制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。
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5.发明授权公开(公告)号：US08765766B2
公开(公告)日：2014-07-01
申请号：US13353287
申请日：2012-01-18
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
IPC: A61K31/506 , C07D239/24
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物; 其中R1，R2，R3，R4和R具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。
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Patent Agency Ranking
6.发明授权Vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same 有权玻连蛋白受体拮抗剂衍生物，其制备方法，其作为药物的用途和含有它们的药物组合物公开(公告)号：US07582640B2
公开(公告)日：2009-09-01
申请号：US10536028
申请日：2003-11-12
Applicant: Jean-Marie Ruxer , Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Marie Ruxer , Jean-Michel Lefrancois , Bertrand Heckmann
IPC: C07D471/04 , C07D401/14 , A61K31/506
CPC classification number: C07D401/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物：其中R1，R2，R3，R4和G具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途，以及 含有它们的药物组合物。
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7.发明授权Methods for the use of pyrimidine derivatives which are antagonists of vitronectin receptor 有权使用作为玻连蛋白受体拮抗剂的嘧啶衍生物的方法公开(公告)号：US07846932B2
公开(公告)日：2010-12-07
申请号：US12541876
申请日：2009-08-14
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
IPC: A61K31/505
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物; 其中R1，R2，R3，R4和R具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。
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公开(公告)号：US07825119B2
公开(公告)日：2010-11-02
申请号：US11596597
申请日：2005-05-13
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
IPC: A61K31/505 , C07D401/14
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物：其中R1，R2，R3，R4和R具有说明书中所述的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途，以及 含有它们的药物组合物。
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公开(公告)号：US20120115883A1
公开(公告)日：2012-05-10
申请号：US13353287
申请日：2012-01-18
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
IPC: A61K31/506 , C07D409/14 , C07D401/14 , A61P9/10 , A61P35/00 , A61P35/04 , A61P9/00 , C07D471/04 , A61P19/10
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物; 其中R1，R2，R3，R4和R具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。
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公开(公告)号：US20110039867A1
公开(公告)日：2011-02-17
申请号：US12911691
申请日：2010-10-25
Applicant: Jean-Michel Lefrancois , Bertrand Heckmann
Inventor： Jean-Michel Lefrancois , Bertrand Heckmann
IPC: A61K31/506 , C07D401/14 , C07D471/04 , C07D409/14 , A61P9/10
CPC classification number: A61K31/506 , C07D239/24 , C07D401/14 , C07D403/14 , C07D471/04
Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Abstract translation: 本发明的主题是式（I）的化合物; 其中R1，R2，R3，R4和R具有说明书中指出的含义，其制备方法，它们作为对玻连蛋白受体具有拮抗活性的药物的用途和含有它们的药物组合物。
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