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1.发明申请公开(公告)号：US20130252964A1
公开(公告)日：2013-09-26
申请号：US13744517
申请日：2013-01-18
Applicant: Richard W. Scott , Katie Freeman , Haizhong Tang , Gill Diamond
Inventor： Richard W. Scott , Katie Freeman , Haizhong Tang , Gill Diamond
IPC: C07D409/14 , C07D209/86 , C07D249/06 , C07D239/26 , C07C237/08 , C07C279/12 , C07C211/27 , C07C211/28 , C07C279/08 , C07C217/20 , C07D333/20 , C07D307/52 , C07D277/28 , C07D239/38 , C07D333/76 , C07D307/91 , C07D239/28
CPC classification number: A61K31/506 , A01N25/00 , A61K9/0053 , A61K9/06 , A61K31/381 , A61K31/404 , A61K31/4192 , A61K31/4436 , A61K31/496 , A61K31/505 , C07C211/27 , C07C211/28 , C07C211/29 , C07C217/20 , C07C237/08 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/12 , C07D209/86 , C07D239/26 , C07D239/28 , C07D239/38 , C07D249/06 , C07D277/28 , C07D307/52 , C07D307/91 , C07D333/20 , C07D333/76 , C07D409/14
Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.
Abstract translation: 本公开内容提供了用于杀死或抑制念珠菌或曲霉菌种的生长或预防或治疗具有念珠菌病（口服和/或播撒）或曲霉属感染的哺乳动物的化合物或其药学上可接受的盐。
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公开(公告)号：US20120039945A1
公开(公告)日：2012-02-16
申请号：US13177056
申请日：2011-07-06
Applicant: Richard W. Scott , Gill Diamond
Inventor： Richard W. Scott , Gill Diamond
IPC: A61K31/167 , A61P31/04 , A61K31/197 , A61P37/02 , A61K31/166 , A61K31/505
CPC classification number: A61K31/166 , A61K31/167 , A61K31/197 , A61K31/505 , Y02A50/473
Abstract: The present invention provides compounds and compositions thereof that modulate the immune system.
Abstract translation: 本发明提供调节免疫系统的化合物及其组合物。
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公开(公告)号：US20100105703A1
公开(公告)日：2010-04-29
申请号：US12605584
申请日：2009-10-26
Applicant: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
Inventor： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC: A61K31/506 , C07D403/14 , A61P31/04
CPC classification number: C07D403/14
Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
Abstract translation: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
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公开(公告)号：US20100081665A1
公开(公告)日：2010-04-01
申请号：US12510593
申请日：2009-07-28
Applicant: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
Inventor： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC: A61K31/496 , C07C237/14 , A61K31/167 , C07D403/12 , A61K31/495 , C07D239/26 , A61P33/06
CPC classification number: C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
Abstract: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
Abstract translation: 本发明提供了三环化合物，芳酰胺化合物和其它化合物及其组合物，包含其的用于治疗疟疾的组合物，以及治疗疟疾的方法，包括向动物施用此类化合物。
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公开(公告)号：US08796275B2
公开(公告)日：2014-08-05
申请号：US12510593
申请日：2009-07-28
Applicant: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
Inventor： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC: C07D241/04 , C07D209/58 , C07D307/91 , C07D333/76 , A61K31/381
CPC classification number: C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
Abstract: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
Abstract translation: 本发明提供了三环化合物，芳酰胺化合物和其它化合物及其组合物，包含其的用于治疗疟疾的组合物，以及治疗疟疾的方法，包括向动物施用此类化合物。
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Patent Agency Ranking
公开(公告)号：US08278309B2
公开(公告)日：2012-10-02
申请号：US12605584
申请日：2009-10-26
Applicant: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
Inventor： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC: A01N43/54 , C07D239/02
CPC classification number: C07D403/14
Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
Abstract translation: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
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7.发明授权Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring 失效基因靶向的非人类哺乳动物与人类衰老早老素突变和代代后代公开(公告)号：US06734336B1
公开(公告)日：2004-05-11
申请号：US09621897
申请日：2000-07-20
Applicant: Richard W. Scott , Andrew G. Reaume , Karen Dorfman
Inventor： Richard W. Scott , Andrew G. Reaume , Karen Dorfman
IPC: C12N500
CPC classification number: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/0312 , C07K14/4711 , C12N2800/30 , G01N33/5082 , G01N33/6896
Abstract: The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized A&bgr; mutation, and generational offspring thereof and a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD PS-1 gene and a human Swedish APP695 mutation, and generational offspring thereof, as well as methods of identifying compounds useful in treating Alzheimer's disease, and to methods of treating Alzheimer's disease.
Abstract translation: 本发明提供了具有编码突变的FAD早老蛋白-1（PS-1）基因，人FAD瑞典突变和人源化Abeta突变的突变蛋白产物的基因靶向的非人哺乳动物和代代后代 和具有编码突变的FAD PS-1基因和人瑞典APP695突变的突变蛋白产物的基因的基因靶向非人哺乳动物及其代谢后代，以及鉴定用于治疗阿尔茨海默病的化合物的方法 疾病和治疗阿尔茨海默病的方法。
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公开(公告)号：US5869336A
公开(公告)日：1999-02-09
申请号：US896116
申请日：1997-07-17
Applicant: Sheryl L. Meyer , Richard W. Scott , Robert Siman
Inventor： Sheryl L. Meyer , Richard W. Scott , Robert Siman
CPC classification number: C12N9/6472 , C12N2799/026
Abstract: The present invention is directed to mammalian enzymatically active calpain produced in insect cells by recombinant means. Recombinant vectors and baculoviruses containing cDNA encoding the 80 kDa subunit, 30 kDa subunit, and both subunits are described. Methods for producing recombinant enzymatically active mammalian calpain are also described.
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9.发明申请Antagonizing Heparin With Salicylamide Compounds And Histamine Blocking Agents 审中-公开拮抗肝素与水杨酰胺化合物和组胺阻断剂公开(公告)号：US20140162955A1
公开(公告)日：2014-06-12
申请号：US14100811
申请日：2013-12-09
Applicant: Richard W. Scott , Bozena Korczak , Nicholas Landekic
Inventor： Richard W. Scott , Bozena Korczak , Nicholas Landekic
IPC: C07C237/44 , C07C279/14 , C07K5/06 , A61K38/05 , A61K31/495 , A61K31/4164 , A61K31/451 , A61K31/445 , A61K31/4402 , A61K31/5415 , A61K31/167 , A61K31/135
CPC classification number: C07C237/44 , A61K31/135 , A61K31/167 , A61K31/4164 , A61K31/4402 , A61K31/445 , A61K31/451 , A61K31/4545 , A61K31/495 , A61K31/5415 , A61K45/06 , C07B2200/07 , C07C279/14 , A61K2300/00
Abstract: The present disclosure provides combinations of salicylamide compounds, or pharmaceutically acceptable salts thereof, and histamine blocking agents, or pharmaceutically acceptable salts thereof, for antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
Abstract translation: 本公开提供了用于拮抗未分级肝素，低分子量肝素或肝素/低分子量肝素衍生物的水杨酰胺化合物或其药学上可接受的盐和组胺封闭剂或其药学上可接受的盐的组合。
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10.发明申请Facially Amphiphilic Compounds, Compositions, And Uses Thereof In Treating Cancer 审中-公开表面两性化合物，组合物及其用途在治疗癌症公开(公告)号：US20120115877A1
公开(公告)日：2012-05-10
申请号：US13214177
申请日：2011-08-20
Applicant: Richard W. Scott , Dylan Clements , Yongjiang Xu , Haizhong Tang , Carol Mulrooney , Ehab Khalil , Damian Weaver , Xiaodong Fan
Inventor： Richard W. Scott , Dylan Clements , Yongjiang Xu , Haizhong Tang , Carol Mulrooney , Ehab Khalil , Damian Weaver , Xiaodong Fan
IPC: A61K31/496 , A61K31/4025 , A61P35/00 , A61K31/343 , A61P35/02 , A61K31/505 , A61K31/381
Abstract: The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans.
Abstract translation: 本发明公开了表面两亲化合物的组合物及其用于治疗或减少动物如人类的癌症的方法。
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