公开(公告)号：US12065413B2

公开(公告)日：2024-08-20

申请号：US17331113

申请日：2021-05-26

Applicant: The Johns Hopkins University

Inventor： Martin G. Pomper ,  Ronnie C. Mease ,  Ying Chen ,  Sangeeta Ray

IPC: A61K51/00 ,  A61K49/00 ,  A61K51/04 ,  A61M36/14 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D257/02 ,  C07D311/14 ,  C07D311/20 ,  C07D311/82 ,  C07F5/02 ,  C07F13/00 ,  G01N33/50

CPC classification number: C07D257/02 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0421 ,  A61K51/044 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0472 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D311/14 ,  C07D311/20 ,  C07D311/82 ,  C07F5/027 ,  C07F13/005 ,  G01N33/5091 ,  G01N2800/342

Abstract: Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

公开(公告)号：US20180111898A1

公开(公告)日：2018-04-26

申请号：US15565992

申请日：2016-04-19

Applicant: DAIKIN INDUSTRIES, LTD. ,  National University Corporation Hokkaido University

Inventor： Masahiro HIGASHI ,  Yosuke KISHIKAWA ,  Shoji HARA

IPC: C07C319/20 ,  C07B39/00

CPC classification number: C07C319/20 ,  C01B7/24 ,  C07B39/00 ,  C07C323/12 ,  C07D213/04

Abstract: An object of the present invention is to provide a method for producing a fluorinated organic compound with a high yield without using carbon tetrachloride in view of the fact that the production of a fluorinated organic compound with a sufficient yield was impossible for a hitherto-known method that uses a fluorinating agent that contains IF5-pyridine-HF alone. Another object of the present invention is to provide a fluorinating reagent that is capable of achieving this object. The present invention provides a composition comprising (1) IF5 and (2) an aprotic solvent (with the proviso that carbon tetrachloride is excluded), wherein the aprotic solvent is contained in an amount within a range of 50 mass ppm to 20 mass %.

公开(公告)号：US09776977B2

公开(公告)日：2017-10-03

申请号：US14243535

申请日：2014-04-02

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： Martin G. Pomper ,  Ronnie C. Mease ,  Sangeeta Ray

IPC: A61K51/00 ,  A61M36/14 ,  C07D257/02 ,  C07D209/14 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D311/14 ,  C07D311/82 ,  A61K49/00 ,  A61K51/04 ,  C07D209/12 ,  C07D311/20 ,  C07F5/02 ,  C07F13/00 ,  G01N33/50

CPC classification number: C07D257/02 ,  A61K49/0052 ,  A61K51/0421 ,  A61K51/044 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0472 ,  C07D209/12 ,  C07D209/14 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D311/14 ,  C07D311/20 ,  C07D311/82 ,  C07F5/027 ,  C07F13/005 ,  G01N33/5091

Abstract: Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.

公开(公告)号：US20170253596A2

公开(公告)日：2017-09-07

申请号：US14772737

申请日：2014-02-27

Applicant: Aquinox Pharmaceuticals (Canada) Inc.

Inventor： Lloyd F. Mackenzie ,  Curtis Harwig ,  David Bogucki ,  Jeffery R. Raymond ,  Jeremy D. Pettigrew

IPC: C07D473/34 ,  C07C215/42 ,  C07C233/23 ,  C07D207/335 ,  C07C311/04 ,  C07C225/10 ,  C07D207/06 ,  C07D213/38 ,  C07C233/74 ,  C07D231/12 ,  C07D249/08 ,  C07D233/60 ,  C07D209/08 ,  C07D317/46 ,  C07D295/096 ,  C07D213/64 ,  C07D239/34 ,  C07D241/18 ,  C07C255/31 ,  C07C275/24 ,  C07C279/08

CPC classification number: C07D473/34 ,  C07C35/21 ,  C07C35/32 ,  C07C59/46 ,  C07C62/32 ,  C07C215/42 ,  C07C215/50 ,  C07C215/52 ,  C07C225/10 ,  C07C233/18 ,  C07C233/23 ,  C07C233/60 ,  C07C233/74 ,  C07C235/30 ,  C07C235/44 ,  C07C235/46 ,  C07C235/48 ,  C07C255/31 ,  C07C261/04 ,  C07C275/10 ,  C07C275/24 ,  C07C275/34 ,  C07C279/08 ,  C07C291/04 ,  C07C311/04 ,  C07C335/10 ,  C07C2602/24 ,  C07C2603/14 ,  C07D207/06 ,  C07D207/08 ,  C07D207/335 ,  C07D207/416 ,  C07D209/08 ,  C07D213/04 ,  C07D213/30 ,  C07D213/36 ,  C07D213/38 ,  C07D213/64 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D233/60 ,  C07D233/72 ,  C07D235/06 ,  C07D235/14 ,  C07D239/34 ,  C07D241/18 ,  C07D241/28 ,  C07D249/08 ,  C07D295/096 ,  C07D307/68 ,  C07D317/46 ,  C07D317/58

Abstract: Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

公开(公告)号：US09682925B2

公开(公告)日：2017-06-20

申请号：US15005574

申请日：2016-01-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Naoki Tomita ,  Shigeo Kajii ,  Douglas Robert Cary ,  Daisuke Tomita ,  Shinichi Imamura ,  Ken Tsuchida ,  Satoru Matsuda ,  Ryujiro Hara

IPC: A61K31/167 ,  A61K31/36 ,  A61K31/366 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/428 ,  A61K31/429 ,  A61K31/433 ,  A61K31/451 ,  A61K31/495 ,  A61K31/55 ,  C07C233/80 ,  A61K31/381 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/4468 ,  C07D309/14 ,  C07C271/22 ,  C07D317/58 ,  C07D223/16 ,  C07D231/14 ,  C07D231/20 ,  C07D231/22 ,  C07D333/20 ,  C07D231/56 ,  C07D233/61 ,  C07D233/64 ,  C07D405/04 ,  C07D239/36 ,  C07D409/04 ,  C07D471/04 ,  C07D261/08 ,  C07D261/10 ,  C07D263/32 ,  C07D263/34 ,  C07C235/56 ,  C07D207/06 ,  C07C237/40 ,  C07D495/04 ,  C07D207/337 ,  C07D277/20 ,  C07D277/28 ,  C07D277/30 ,  C07D209/08 ,  C07D277/62 ,  C07D209/42 ,  C07D513/04 ,  C07D209/46 ,  C07D209/48 ,  C07D285/06 ,  C07D211/56 ,  C07D211/58 ,  C07D295/14 ,  C07D211/76 ,  C07D213/04 ,  C07D213/38 ,  C07D213/56 ,  C07D211/98 ,  C07D335/02 ,  C07C237/42 ,  C07C271/20 ,  C07D211/40 ,  C07D231/26 ,  C07D295/135 ,  C07D295/155

CPC classification number: C07C233/80 ,  A61K31/167 ,  A61K31/36 ,  A61K31/366 ,  A61K31/381 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/428 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/495 ,  A61K31/55 ,  C07C235/56 ,  C07C237/40 ,  C07C237/42 ,  C07C271/20 ,  C07C271/22 ,  C07C2601/02 ,  C07C2601/18 ,  C07C2602/08 ,  C07D207/06 ,  C07D207/337 ,  C07D209/08 ,  C07D209/42 ,  C07D209/46 ,  C07D209/48 ,  C07D211/40 ,  C07D211/56 ,  C07D211/58 ,  C07D211/76 ,  C07D211/98 ,  C07D213/04 ,  C07D213/38 ,  C07D213/56 ,  C07D223/16 ,  C07D231/14 ,  C07D231/20 ,  C07D231/22 ,  C07D231/26 ,  C07D231/56 ,  C07D233/61 ,  C07D233/64 ,  C07D239/36 ,  C07D261/08 ,  C07D261/10 ,  C07D263/32 ,  C07D263/34 ,  C07D277/20 ,  C07D277/28 ,  C07D277/30 ,  C07D277/62 ,  C07D285/06 ,  C07D295/135 ,  C07D295/14 ,  C07D295/155 ,  C07D309/14 ,  C07D317/58 ,  C07D333/20 ,  C07D335/02 ,  C07D405/04 ,  C07D409/04 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q1, Q2, Q3 and Q4 are each a hydrogen atom or a substituent; Q1 and Q2, and Q3 and Q4, are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y1, Y2 and Y3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y1, and Y1 and Y2, are each optionally bonded to each other to form a ring optionally having substituent(s); and Z1, Z2 and Z3 are each H or a substituent, or a salt thereof.

公开(公告)号：US20150104387A1

公开(公告)日：2015-04-16

申请号：US14243535

申请日：2014-04-02

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： MARTIN G. POMPER ,  RONNIE C. MEASE ,  YING CHEN ,  Sangeeta Ray

IPC: C07F5/02 ,  A61K49/00 ,  A61K51/04 ,  G01N33/50 ,  C07D311/82 ,  C07F13/00 ,  C07D209/12 ,  C07D311/20 ,  C07D249/04 ,  C07D257/02

CPC classification number: C07D257/02 ,  A61K49/0052 ,  A61K51/0421 ,  A61K51/044 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0472 ,  C07D209/12 ,  C07D209/14 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D311/14 ,  C07D311/20 ,  C07D311/82 ,  C07F5/027 ,  C07F13/005 ,  G01N33/5091

Abstract: Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.

Abstract translation: 描述了前列腺特异性膜抗原（PSMA）靶向化合物。 还描述了用于成像，治疗，细胞分选和肿瘤作图的化合物的用途。

公开(公告)号：US08476043B2

公开(公告)日：2013-07-02

申请号：US12631577

申请日：2009-12-04

Applicant: Bruce D. Hammock ,  In-Hae Kim ,  Christophe Morisseau ,  Takaho Watanabe ,  John W. Newman

Inventor： Bruce D. Hammock ,  In-Hae Kim ,  Christophe Morisseau ,  Takaho Watanabe ,  John W. Newman

IPC: C12P19/48 ,  C07C211/16 ,  C12Q1/34

CPC classification number: C07D295/088 ,  C07C233/06 ,  C07C233/08 ,  C07C235/14 ,  C07C275/26 ,  C07C311/04 ,  C07C311/05 ,  C07C311/18 ,  C07C311/41 ,  C07C311/51 ,  C07C323/44 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2601/20 ,  C07C2603/18 ,  C07C2603/74 ,  C07D209/18 ,  C07D213/04 ,  C07D233/61 ,  C07D233/64 ,  C07D279/12 ,  C07D295/13 ,  C07D295/32 ,  C07D403/06 ,  C07K5/0205

Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.

Abstract translation: 提供了可溶性环氧化物水解酶（sEH）的抑制剂，其包含多个药效团并且可用于治疗疾病。

公开(公告)号：US20130144061A1

公开(公告)日：2013-06-06

申请号：US13756939

申请日：2013-02-01

Applicant: DAIICHI SANKYO COMPANY, LIMITED

Inventor： Koutarou Kawanami

IPC: C07D498/04

CPC classification number: C07D513/04 ,  C07C201/12 ,  C07C253/30 ,  C07D213/04 ,  C07C205/12 ,  C07C255/50

Abstract: The present invention provides a novel process for preparing a substituted aromatic compound such as an aromatic halo compound or a salt thereof through a transformation reaction of an aromatic diazonium salt from an aromatic amino compound at stable high yields utilizing a novel Sandmeyer-like reaction using a nitroxide radical compound as a reaction catalyst.

Abstract translation: 本发明提供了一种新颖的方法，通过芳族氨基化合物的芳族重氮盐以稳定的高收率利用芳族卤代化合物或其盐制备取代的芳族化合物，利用新型的Sandmeyer样反应 硝基氧自由基化合物作为反应催化剂。

公开(公告)号：US20120015911A1

公开(公告)日：2012-01-19

申请号：US13237576

申请日：2011-09-20

Applicant: Xianqi Kong ,  Xinfu Wu ,  Abderrahim Bouzide ,  Isabelle Valade ,  David Migneault ,  Francine Gervais ,  Daniel Delorme ,  Benoit Bachand ,  Mohamed Atfani ,  Sophie Levesque ,  Bita Samim

Inventor： Xianqi Kong ,  Xinfu Wu ,  Abderrahim Bouzide ,  Isabelle Valade ,  David Migneault ,  Francine Gervais ,  Daniel Delorme ,  Benoit Bachand ,  Mohamed Atfani ,  Sophie Levesque ,  Bita Samim

IPC: A61K31/655 ,  A61K31/437 ,  A61K31/4462 ,  A61K31/4184 ,  A61K31/40 ,  A61K31/381 ,  A61K31/341 ,  A61K31/22 ,  A61K31/195 ,  A61K31/13 ,  C07C245/10 ,  C07D471/04 ,  C07D211/96 ,  A61K31/4458 ,  C07D235/28 ,  C07D207/46 ,  C07D409/06 ,  C07D333/20 ,  C07D307/66 ,  C07C317/28 ,  C07C309/23 ,  C07D307/22 ,  A61P43/00 ,  A61P25/28 ,  A61P25/00 ,  A61P27/02 ,  A61P3/10 ,  A61K31/56

CPC classification number: C07C309/19 ,  C07C309/14 ,  C07C309/21 ,  C07C309/24 ,  C07C309/26 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/12 ,  C07D207/333 ,  C07D209/08 ,  C07D209/16 ,  C07D209/36 ,  C07D209/44 ,  C07D209/48 ,  C07D209/86 ,  C07D211/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/34 ,  C07D211/48 ,  C07D211/52 ,  C07D211/58 ,  C07D211/64 ,  C07D211/70 ,  C07D211/82 ,  C07D213/04 ,  C07D213/20 ,  C07D213/50 ,  C07D213/75 ,  C07D213/82 ,  C07D217/04 ,  C07D219/10 ,  C07D231/44 ,  C07D233/54 ,  C07D235/28 ,  C07D257/04 ,  C07D275/06 ,  C07D277/66 ,  C07D295/073 ,  C07D295/088 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07D327/04 ,  C07D327/06 ,  C07D327/08 ,  C07D333/20 ,  C07D333/34 ,  C07D409/04 ,  C07D471/04 ,  C07D471/08 ,  C07K5/06

Abstract: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

Abstract translation: 描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。

公开(公告)号：US08076483B2

公开(公告)日：2011-12-13

申请号：US12299615

申请日：2007-05-09

Applicant: Saxena Rahul ,  Jain Anshul Kumar ,  Srinivasan Chidambaram Venkateswaran ,  Wadhwa Lalit

Inventor： Saxena Rahul ,  Jain Anshul Kumar ,  Srinivasan Chidambaram Venkateswaran ,  Wadhwa Lalit

IPC: C07F9/06 ,  A61K31/66

CPC classification number: C07D213/55 ,  C07D213/04 ,  C07F9/58

Abstract: The present invention relates to an industrially advantageous process of making bisphosphonic acid or its salt in particular risedronic acid, [1-hydroxy-2(3-pyridinyl)ethylidene]bisphosphonic acid, having formula-(I) or its salts in high purity and high yields.

Abstract translation: 本发明涉及工业上有利的制备双膦酸或其盐特别是具有式 - （I）或其高纯度盐的[1-羟基-2（3-吡啶基）亚乙基]双膦酸的双膦酸或其盐的方法， 高产量。