公开(公告)号：US20200297693A1

公开(公告)日：2020-09-24

申请号：US16899226

申请日：2020-06-11

申请人： The Johns Hopkins University ,  Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

发明人： JUN LIU ,  QINGLI HE ,  MARTIN G. POMPER ,  IL MINN ,  BIAO YU ,  QIAOLING WANG

IPC分类号： A61K31/365 ,  C07D493/22 ,  C07J73/00 ,  A61K47/54 ,  A61P35/00 ,  C07H15/26

摘要： Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

公开(公告)号：US20200155713A1

公开(公告)日：2020-05-21

申请号：US16087395

申请日：2017-03-22

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： SANGEETA RAY ,  MARTIN G. POMPER

IPC分类号： A61K51/04 ,  C07D257/02 ,  C07D401/12 ,  A61P35/00

摘要： Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.

公开(公告)号：US20190023722A9

公开(公告)日：2019-01-24

申请号：US15557854

申请日：2016-03-14

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： MARTIN G. POMPER ,  RONNIE C. MEASE ,  SANGEETA RAY

IPC分类号： C07F5/00 ,  A61K51/04

摘要： PSMA-targeted PET/SPECT agents for imaging PSMA-positive cancer and or tumor neovasculature and PSMA-targeted radiotherapeutic agent for the treatment of PSMA-positive cancer or tumor neovasculature are disclosed. Methods of imaging PSMA expressing tumors, or cells and kits also are disclosed.

公开(公告)号：US20160331845A1

公开(公告)日：2016-11-17

申请号：US15154143

申请日：2016-05-13

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： HAI-QUAN MAO ,  JOHN MICHAEL WILLIFORD ,  MAANI ARCHANG ,  IL MINN ,  YONG REN ,  JOSE LUIS SANTOS ,  MARTIN G. POMPER

IPC分类号： A61K48/00 ,  A61K47/48 ,  A61K45/06 ,  A61K51/04

CPC分类号： A61K48/0041 ,  A61K45/06 ,  A61K47/59 ,  A61K47/60 ,  A61K47/62 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6935 ,  C12N15/88 ,  C12N2810/855 ,  C12N2810/856

摘要： Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (PEG) polymer having an average molecular weight less than 1 kDa, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.

摘要翻译： 包含聚合物胶束纳米颗粒组合物的组合物，其包含包含至少一种聚阳离子聚合物和至少一种平均分子量小于1kDa的聚乙二醇（PEG）聚合物的嵌段或接枝共聚物和至少一种核酸，其中所述移植物或 嵌段共聚物和至少一种核酸被络合并缩合成在生物培养基中稳定的成形胶束纳米颗粒。 目前公开的主题还提供了制备本发明公开的高分子胶束纳米颗粒组合物的方法，靶向受试者中至少一种转移性癌细胞的方法，以及使用本发明公开的高分子胶束纳米颗粒组合物治疗疾病或病症的方法 。

公开(公告)号：US20180133348A1

公开(公告)日：2018-05-17

申请号：US15578473

申请日：2016-06-01

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： XING YANG ,  IL MINN ,  STEVEN ROWE ,  SANGEETA RAY ,  RONNIE C. MEASE ,  MICHAEL GORIN ,  MOHAMAD ALLAF ,  MARTIN G. POMPER

IPC分类号： A61K51/04 ,  A61P35/00

CPC分类号： A61K51/0497 ,  A61P35/00 ,  C07D417/12 ,  C07D417/14

摘要： Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.

公开(公告)号：US20170283384A1

公开(公告)日：2017-10-05

申请号：US15618788

申请日：2017-06-09

申请人： THE JOHNS HOPKINS UNIVERSITY ,  INTUITIVE SURGICAL OPERATIONS, INC.

发明人： MARTIN G. POMPER ,  RONNIE C. MEASE ,  YING CHEN ,  SANGEETA RAY ,  JONATHAN SORGER

IPC分类号： C07D257/02 ,  A61K51/04 ,  C07D311/82 ,  C07D213/04 ,  C07D209/14 ,  C07D249/04 ,  C07F5/02 ,  C07D209/12 ,  C07D255/02 ,  A61K49/00 ,  G01N33/50 ,  C07D311/14 ,  C07D311/20 ,  C07F13/00

CPC分类号： C07D257/02 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0421 ,  A61K51/044 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0472 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D311/14 ,  C07D311/20 ,  C07D311/82 ,  C07F5/027 ,  C07F13/005 ,  G01N33/5091 ,  G01N2800/342

摘要： Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

公开(公告)号：US20170081298A1

公开(公告)日：2017-03-23

申请号：US15309009

申请日：2015-05-06

申请人： THE JOHNS HOPKINS UNIVERSITY ,  NORTHWESTERN UNIVERSITY

发明人： SANGEETA RAY ,  MARTIN G. POMPER ,  THOMAS J. MEADE ,  RONNIE C. MEASE ,  YING CHEN ,  XING YANG ,  MATTHEW ROTZ

IPC分类号： C07D257/02 ,  A61K49/10 ,  A61K51/04 ,  C07D403/14

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：US20150246144A1

公开(公告)日：2015-09-03

申请号：US14715115

申请日：2015-05-18

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： MARTIN G. POMPER ,  SANGEETA RAY ,  RONNIE C. MEASE ,  CATHERINE ANNE FOSS

IPC分类号： A61K51/04 ,  C07D213/38 ,  C12Q1/37 ,  C07F13/00 ,  G01N33/60 ,  C07D257/02 ,  C07D215/12

CPC分类号： A61K51/0472 ,  A61K31/145 ,  A61K31/195 ,  A61K31/395 ,  A61K31/4402 ,  A61K38/06 ,  A61K51/0402 ,  C07D213/38 ,  C07D215/12 ,  C07D257/00 ,  C07D257/02 ,  C07F13/00 ,  C12Q1/37 ,  G01N33/57434 ,  G01N33/60 ,  G01N2500/04 ,  A61K2300/00

摘要： The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mTc/Re-labeled compounds were prepared by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor with or without a variable length linker moiety. Ex vivo biodistribution and in vivo imaging demonstrated the degree of specific binding to engineered PSMA+PC3 PIP tumors.

摘要翻译： 前列腺特异性膜抗原（PSMA）越来越被认为是癌症成像和治疗的可行靶标。 通过将已知的Tc / Re螯合剂连接到具有或不具有可变长度连接体部分的氨基官能化PSMA抑制剂中来制备各种99mTc / Re标记的化合物。 离体生物分布和体内成像证明了与工程化PSMA + PC3 PIP肿瘤的特异性结合程度。

公开(公告)号：US20190225589A1

公开(公告)日：2019-07-25

申请号：US15752340

申请日：2016-08-15

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： MARTIN G. POMPER ,  YING CHEN ,  XING YANG ,  RONNIE C. MEASE ,  SANGEETA RAY

IPC分类号： C07D249/04 ,  C07B59/00

摘要： Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.

公开(公告)号：US20190134235A1

公开(公告)日：2019-05-09

申请号：US16098694

申请日：2017-05-04

申请人： THE JOHNS HOPKINS UNIVERSITY ,  OREGON HEALTH & SCIENCE UNIVERSITY

发明人： ANDREW HORTI ,  MARTIN G. POMPER ,  NABIL J. ALAYED

IPC分类号： A61K51/04 ,  C07D213/82 ,  C07B59/00

摘要： Radiofluorinated FNDP for PET imaging of soluble epoxide hydrolase (sEH) and method of using the same are disclosed.